Stereocontrolled Synthesis of Cyclopropanol Amino Acids from Allylic Sulfones:  Conformationally Restricted Building Blocks

A new amino acid methyl ester with a cyclopropanol has been synthesized starting from the allyl sulfone 10. The starting material, 10, could be obtained in both enantiomeric forms. The stereoselectivity of the cyclopropane formation has been studied by molecular modeling.

Bibliographische Detailangaben

Veröffentlicht in:	Organic letters 2003-10, Vol.5 (20), p.3687-3690
Hauptverfasser:	Díez, David, Garcia, P, Marcos, Isidro S, Garrido, N. M, Basabe, P, Broughton, Howard B, Urones, Julio G
Format:	Artikel
Sprache:	eng
Schlagworte:	Allyl Compounds - chemistry Amino Acids - chemical synthesis Amino Acids - chemistry Crystallography, X-Ray Cyclization Ethers, Cyclic - chemistry Glutamic Acid - chemistry Models, Molecular Molecular Conformation Molecular Structure Stereoisomerism Sulfones - chemistry
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