Voxel-based morphometry of grey matter densities in subjects at high risk of schizophrenia
The grey matter (GM) segments from T1 structural magnetic resonance (MR) images of the brain in subjects at high risk of schizophrenia ( n=146) were compared with normal control subjects ( n=36) and first episode schizophrenic subjects ( n=34) using automated voxel-based morphometry (VBM). The subje...
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| Veröffentlicht in: | Schizophrenia research 2003-11, Vol.64 (1), p.1-13 |
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| creator | Job, Dominic E. Whalley, Heather C. McConnell, Sarah Glabus, Mike Johnstone, Eve C. Lawrie, Stephen M. |
| description | The grey matter (GM) segments from T1 structural magnetic resonance (MR) images of the brain in subjects at high risk of schizophrenia (
n=146) were compared with normal control subjects (
n=36) and first episode schizophrenic subjects (
n=34) using automated voxel-based morphometry (VBM). The subjects were recruited for the Edinburgh High Risk Study (EHRS) and regional brain volumes had previously been measured using a semi-automated volumetric region of interest (ROI) method of analysis. For the current report, the images were processed using a study specific template and statistically analysed using the SPM99 program. The small volume correction tool in SPM was also used to restrict the analyses to specific voxels. Reductions in the probability of grey matter (GM) density were seen bilaterally in the anterior cingulate, and as a trend in the left parahippocampal gyrus for the high-risk vs. control subjects. In contrast, first episode schizophrenia subjects had less GM than high-risk subjects in several frontal and temporal regions. These results are compatible with the findings of our previous volumetric ROI analysis. |
| doi_str_mv | 10.1016/S0920-9964(03)00158-0 |
| format | Article |
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n=146) were compared with normal control subjects (
n=36) and first episode schizophrenic subjects (
n=34) using automated voxel-based morphometry (VBM). The subjects were recruited for the Edinburgh High Risk Study (EHRS) and regional brain volumes had previously been measured using a semi-automated volumetric region of interest (ROI) method of analysis. For the current report, the images were processed using a study specific template and statistically analysed using the SPM99 program. The small volume correction tool in SPM was also used to restrict the analyses to specific voxels. Reductions in the probability of grey matter (GM) density were seen bilaterally in the anterior cingulate, and as a trend in the left parahippocampal gyrus for the high-risk vs. control subjects. In contrast, first episode schizophrenia subjects had less GM than high-risk subjects in several frontal and temporal regions. These results are compatible with the findings of our previous volumetric ROI analysis.</description><identifier>ISSN: 0920-9964</identifier><identifier>EISSN: 1573-2509</identifier><identifier>DOI: 10.1016/S0920-9964(03)00158-0</identifier><identifier>PMID: 14511796</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Acute Disease ; Adolescent ; Adult ; Adult and adolescent clinical studies ; Amygdala - pathology ; Biological and medical sciences ; Brain - pathology ; Brain Mapping ; Dominance, Cerebral - genetics ; Dominance, Cerebral - physiology ; Female ; Frontal Lobe - pathology ; Genetic Predisposition to Disease - genetics ; Grey matter ; Gyrus Cinguli - pathology ; Humans ; Image Interpretation, Computer-Assisted ; Magnetic Resonance Imaging ; Male ; Mathematical Computing ; Medical sciences ; Parahippocampal Gyrus - pathology ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Reference Values ; Risk ; Schizophrenia ; Schizophrenia - diagnosis ; Schizophrenia - genetics ; Schizophrenic Psychology ; Schizotypal Personality Disorder - diagnosis ; Schizotypal Personality Disorder - genetics ; Schizotypal Personality Disorder - psychology ; Statistical parametric mapping ; Temporal Lobe - pathology ; Voxel-based morphometry</subject><ispartof>Schizophrenia research, 2003-11, Vol.64 (1), p.1-13</ispartof><rights>2003 Elsevier B.V.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-9a572540ba21e5873f386a732aa28014c636301902623a4db3c6e96ee4a9967b3</citedby><cites>FETCH-LOGICAL-c391t-9a572540ba21e5873f386a732aa28014c636301902623a4db3c6e96ee4a9967b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0920996403001580$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15143829$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14511796$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Job, Dominic E.</creatorcontrib><creatorcontrib>Whalley, Heather C.</creatorcontrib><creatorcontrib>McConnell, Sarah</creatorcontrib><creatorcontrib>Glabus, Mike</creatorcontrib><creatorcontrib>Johnstone, Eve C.</creatorcontrib><creatorcontrib>Lawrie, Stephen M.</creatorcontrib><title>Voxel-based morphometry of grey matter densities in subjects at high risk of schizophrenia</title><title>Schizophrenia research</title><addtitle>Schizophr Res</addtitle><description>The grey matter (GM) segments from T1 structural magnetic resonance (MR) images of the brain in subjects at high risk of schizophrenia (
n=146) were compared with normal control subjects (
n=36) and first episode schizophrenic subjects (
n=34) using automated voxel-based morphometry (VBM). The subjects were recruited for the Edinburgh High Risk Study (EHRS) and regional brain volumes had previously been measured using a semi-automated volumetric region of interest (ROI) method of analysis. For the current report, the images were processed using a study specific template and statistically analysed using the SPM99 program. The small volume correction tool in SPM was also used to restrict the analyses to specific voxels. Reductions in the probability of grey matter (GM) density were seen bilaterally in the anterior cingulate, and as a trend in the left parahippocampal gyrus for the high-risk vs. control subjects. In contrast, first episode schizophrenia subjects had less GM than high-risk subjects in several frontal and temporal regions. These results are compatible with the findings of our previous volumetric ROI analysis.</description><subject>Acute Disease</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Amygdala - pathology</subject><subject>Biological and medical sciences</subject><subject>Brain - pathology</subject><subject>Brain Mapping</subject><subject>Dominance, Cerebral - genetics</subject><subject>Dominance, Cerebral - physiology</subject><subject>Female</subject><subject>Frontal Lobe - pathology</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Grey matter</subject><subject>Gyrus Cinguli - pathology</subject><subject>Humans</subject><subject>Image Interpretation, Computer-Assisted</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Mathematical Computing</subject><subject>Medical sciences</subject><subject>Parahippocampal Gyrus - pathology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Reference Values</subject><subject>Risk</subject><subject>Schizophrenia</subject><subject>Schizophrenia - diagnosis</subject><subject>Schizophrenia - genetics</subject><subject>Schizophrenic Psychology</subject><subject>Schizotypal Personality Disorder - diagnosis</subject><subject>Schizotypal Personality Disorder - genetics</subject><subject>Schizotypal Personality Disorder - psychology</subject><subject>Statistical parametric mapping</subject><subject>Temporal Lobe - pathology</subject><subject>Voxel-based morphometry</subject><issn>0920-9964</issn><issn>1573-2509</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtP3DAURi3UCoYpP4HKmyK6SOtHbMerCqG-JCQWfSy6sRznhpgm8dQ3UzH8ejLMCJas7l2c7z4OIaecfeCM648_mBWssFaX50y-Z4yrqmAHZMGVkYVQzL4iiyfkiBwj3rItxcwhOeKl4txYvSB_fqc76IvaIzR0SHnVpQGmvKGppTcZNnTw0wSZNjBinCIgjSPFdX0LYULqJ9rFm47miH-3CQxdvE-rLsMY_RvyuvU9wsm-LsmvL59_Xn4rrq6_fr-8uCqCtHwqrFdGqJLVXnBQlZGtrLQ3UngvKsbLoKWWjFsmtJC-bGoZNFgNUPr5NVPLJTnbzV3l9G8NOLkhYoC-9yOkNTqjDJ-zagbVDgw5IWZo3SrHweeN48xtpbpHqW5rzDHpHqXOzZK83S9Y1wM0z6m9xRl4twc8Bt-32Y8h4jOneCkrYWfu046DWcf_CNlhiDAGaGKefbomxRdOeQBlwJMU</recordid><startdate>20031101</startdate><enddate>20031101</enddate><creator>Job, Dominic E.</creator><creator>Whalley, Heather C.</creator><creator>McConnell, Sarah</creator><creator>Glabus, Mike</creator><creator>Johnstone, Eve C.</creator><creator>Lawrie, Stephen M.</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20031101</creationdate><title>Voxel-based morphometry of grey matter densities in subjects at high risk of schizophrenia</title><author>Job, Dominic E. ; Whalley, Heather C. ; McConnell, Sarah ; Glabus, Mike ; Johnstone, Eve C. ; Lawrie, Stephen M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-9a572540ba21e5873f386a732aa28014c636301902623a4db3c6e96ee4a9967b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Acute Disease</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Amygdala - pathology</topic><topic>Biological and medical sciences</topic><topic>Brain - pathology</topic><topic>Brain Mapping</topic><topic>Dominance, Cerebral - genetics</topic><topic>Dominance, Cerebral - physiology</topic><topic>Female</topic><topic>Frontal Lobe - pathology</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Grey matter</topic><topic>Gyrus Cinguli - pathology</topic><topic>Humans</topic><topic>Image Interpretation, Computer-Assisted</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Mathematical Computing</topic><topic>Medical sciences</topic><topic>Parahippocampal Gyrus - pathology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Reference Values</topic><topic>Risk</topic><topic>Schizophrenia</topic><topic>Schizophrenia - diagnosis</topic><topic>Schizophrenia - genetics</topic><topic>Schizophrenic Psychology</topic><topic>Schizotypal Personality Disorder - diagnosis</topic><topic>Schizotypal Personality Disorder - genetics</topic><topic>Schizotypal Personality Disorder - psychology</topic><topic>Statistical parametric mapping</topic><topic>Temporal Lobe - pathology</topic><topic>Voxel-based morphometry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Job, Dominic E.</creatorcontrib><creatorcontrib>Whalley, Heather C.</creatorcontrib><creatorcontrib>McConnell, Sarah</creatorcontrib><creatorcontrib>Glabus, Mike</creatorcontrib><creatorcontrib>Johnstone, Eve C.</creatorcontrib><creatorcontrib>Lawrie, Stephen M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Schizophrenia research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Job, Dominic E.</au><au>Whalley, Heather C.</au><au>McConnell, Sarah</au><au>Glabus, Mike</au><au>Johnstone, Eve C.</au><au>Lawrie, Stephen M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Voxel-based morphometry of grey matter densities in subjects at high risk of schizophrenia</atitle><jtitle>Schizophrenia research</jtitle><addtitle>Schizophr Res</addtitle><date>2003-11-01</date><risdate>2003</risdate><volume>64</volume><issue>1</issue><spage>1</spage><epage>13</epage><pages>1-13</pages><issn>0920-9964</issn><eissn>1573-2509</eissn><abstract>The grey matter (GM) segments from T1 structural magnetic resonance (MR) images of the brain in subjects at high risk of schizophrenia (
n=146) were compared with normal control subjects (
n=36) and first episode schizophrenic subjects (
n=34) using automated voxel-based morphometry (VBM). The subjects were recruited for the Edinburgh High Risk Study (EHRS) and regional brain volumes had previously been measured using a semi-automated volumetric region of interest (ROI) method of analysis. For the current report, the images were processed using a study specific template and statistically analysed using the SPM99 program. The small volume correction tool in SPM was also used to restrict the analyses to specific voxels. Reductions in the probability of grey matter (GM) density were seen bilaterally in the anterior cingulate, and as a trend in the left parahippocampal gyrus for the high-risk vs. control subjects. In contrast, first episode schizophrenia subjects had less GM than high-risk subjects in several frontal and temporal regions. These results are compatible with the findings of our previous volumetric ROI analysis.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>14511796</pmid><doi>10.1016/S0920-9964(03)00158-0</doi><tpages>13</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acute Disease Adolescent Adult Adult and adolescent clinical studies Amygdala - pathology Biological and medical sciences Brain - pathology Brain Mapping Dominance, Cerebral - genetics Dominance, Cerebral - physiology Female Frontal Lobe - pathology Genetic Predisposition to Disease - genetics Grey matter Gyrus Cinguli - pathology Humans Image Interpretation, Computer-Assisted Magnetic Resonance Imaging Male Mathematical Computing Medical sciences Parahippocampal Gyrus - pathology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Reference Values Risk Schizophrenia Schizophrenia - diagnosis Schizophrenia - genetics Schizophrenic Psychology Schizotypal Personality Disorder - diagnosis Schizotypal Personality Disorder - genetics Schizotypal Personality Disorder - psychology Statistical parametric mapping Temporal Lobe - pathology Voxel-based morphometry |
| title | Voxel-based morphometry of grey matter densities in subjects at high risk of schizophrenia |
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