Duration-dependent attenuation of acetylcholine—but not histamine—induced relaxation of the aorta in diabetes mellitus

1. The relaxations of aortic preparations from 1, 4 and 12 week diabetic rats to acetylcholine and histamine were studied. 2. The relaxation to acetylcholine but not to histamine was significantly attenuated in the 4th and 12th weeks of the disease. In addition, the tissues became less sensitive to...

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Veröffentlicht in:	General pharmacology 1993-03, Vol.24 (2), p.329-332
Hauptverfasser:	Orie, Nelson N., Aloamaka, Chukwuemeka P., Iyawe, Vincent I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Animals Aorta - drug effects Aorta - physiology Associated diseases and complications Biological and medical sciences Diabetes Mellitus, Experimental - physiopathology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Histamine - pharmacology In Vitro Techniques Male Medical sciences Rats Rats, Wistar Time Factors Vasodilation - drug effects
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