Facilitation of renal autoregulation by angiotensin II is mediated through modulation of nitric oxide

Aims: This study was designed to investigate the influence of angiotensin II (Ang II) and nitric oxide (NO) on autoregulation of renal perfusion. Methods: Autoregulation was investigated in isolated perfused kidneys (IPRK) from Sprague‐Dawley rats during stepped increases in perfusion pressure. Resu...

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Veröffentlicht in:	Acta physiologica Scandinavica 2003-10, Vol.179 (2), p.189-201
Hauptverfasser:	Guan, Z., Willgoss, D. A., Matthias, A., Manley, S. W., Crozier, S., Gobe, G., Endre, Z. H.
Format:	Artikel
Sprache:	eng
Schlagworte:	angiotensin II Angiotensin II - physiology Angiotensin Receptor Antagonists Animals Biological and medical sciences Cyclic N-Oxides - pharmacology endothelium derived hyperpolarizing factor Endothelium-Dependent Relaxing Factors - metabolism erythrocyte perfused rat kidney Erythrocytes - physiology Fundamental and applied biological sciences. Psychology Glomerular Filtration Rate Homeostasis - physiology Indomethacin - pharmacology isolated perfused rat kidney Kidney - drug effects Kidney - physiology Losartan - pharmacology Male myogenic response NG-Nitroarginine Methyl Ester - metabolism nitric oxide Nitric Oxide - physiology Nitric Oxide Synthase - metabolism Perfusion phenylephrine Phenylephrine - metabolism Prostaglandin-Endoperoxide Synthases - metabolism Rats Rats, Sprague-Dawley renal autoregulation Spin Labels tubuloglomerular feedback Vasoconstriction - physiology Vertebrates: urinary system
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