Peptidases and smooth muscle cell angiotensin II receptor pharmacology

Angiotensin (A) II receptors on rat aortic smooth muscle (RASM) cell membranes were characterized using the radioligand [ 125I][Sar 1Ile 8]AII ([ 125I]SI-AII). Angiotensin I, AII, and AIII inhibited specific [ 125I]SI-AII binding, and their rank order of potencies, and K i values ( nM ) were: AII (3...

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Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1993-03, Vol.14 (2), p.345-352
Hauptverfasser:	Cohen, Robert B., Webb, Maria L., Dickinson, Kenneth E.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Cortex - metabolism Angiotensin I - metabolism Angiotensin II - metabolism Angiotensin II receptor Angiotensin III - metabolism Animals Biological and medical sciences Cell Membrane - metabolism Cell receptors Cell structures and functions Cells, Cultured Endopeptidases - metabolism Fundamental and applied biological sciences. Psychology Hormone receptors. Growth factor receptors. Cytokine receptors. Prostaglandin receptors In Vitro Techniques Kinetics Losartan Molecular and cellular biology Muscle, Smooth, Vascular - metabolism Protease inhibitors Protease Inhibitors - pharmacology Rats Receptors, Angiotensin - drug effects Receptors, Angiotensin - metabolism Saralasin - metabolism Smooth muscle cells
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