Inherited Thrombophilia: Impact on Human Reproduction
The development of thrombotic disorders is a major threat for young women during pregnancy. It is one of the main causes of pregnancy‐related disorders, which may also result in harm for the conceptus. Successful pregnancies require an even balance of coagulation and fibrinolysis, in order to secure...
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| Veröffentlicht in: | American journal of reproductive immunology (1989) 2003-07, Vol.50 (1), p.20-32 |
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| container_title | American journal of reproductive immunology (1989) |
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| creator | Buchholz, Tina Thaler, Christian J. |
| description | The development of thrombotic disorders is a major threat for young women during pregnancy. It is one of the main causes of pregnancy‐related disorders, which may also result in harm for the conceptus. Successful pregnancies require an even balance of coagulation and fibrinolysis, in order to secure stabilization of the basal plate as well as adequate placental perfusion. Thrombophilia is a laboratory definition for pre‐disposing factors of thrombosis, which can be inherited or acquired. Many individuals, who carry a thrombotic defect remain asymptomatic, at least until additional boosting factors arise. The documentation of thrombophilic causes of recurrent miscarriage or pregnancy‐related disorders is important, because of availability of effective early treatment. There is a rapidly growing awareness on the relationship of genetic factors influencing hemostasis and pregnancy‐related disorders. The aim of our review is to summarize this knowledge, focusing on common genetic variations. |
| doi_str_mv | 10.1034/j.1600-0897.2003.00049.x |
| format | Article |
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It is one of the main causes of pregnancy‐related disorders, which may also result in harm for the conceptus. Successful pregnancies require an even balance of coagulation and fibrinolysis, in order to secure stabilization of the basal plate as well as adequate placental perfusion. Thrombophilia is a laboratory definition for pre‐disposing factors of thrombosis, which can be inherited or acquired. Many individuals, who carry a thrombotic defect remain asymptomatic, at least until additional boosting factors arise. The documentation of thrombophilic causes of recurrent miscarriage or pregnancy‐related disorders is important, because of availability of effective early treatment. There is a rapidly growing awareness on the relationship of genetic factors influencing hemostasis and pregnancy‐related disorders. The aim of our review is to summarize this knowledge, focusing on common genetic variations.</description><subject>Biological and medical sciences</subject><subject>Blood Coagulation - genetics</subject><subject>Blood Coagulation Factors - genetics</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Female</subject><subject>fibrinolysis</subject><subject>Fibrinolysis - genetics</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>hemostasis</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>placental perfusion</subject><subject>Polymorphism, Genetic</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Hematologic - etiology</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Reproduction - genetics</subject><subject>Thrombophilia - complications</subject><subject>Thrombophilia - genetics</subject><issn>1046-7408</issn><issn>8755-8920</issn><issn>1600-0897</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMtO3DAUQC1UxPsXqmzaXcJ1_EzVDVAegxBIiNfOchxH42keUzsRw9_jYUaUHax8JZ_jax2EEgwZBkIPZxnmACnIQmQ5AMkAgBbZYgPtvF98izNQngoKchvthjCLkCyI2ELbmDLgRc52EJt0U-vdYKvkbur7tuznU9c4_SuZtHNthqTvkoux1V1ya-e-r0YzuL7bR5u1boI9WJ976P7s9O7kIr26OZ-cHF2lhnJSpFLkumC2KjlljNiaGMYlFozxmjJuSssrrHklKs3zmkrIK1pqaUpBBBa6rMke-rl6N67-N9owqNYFY5tGd7YfgxJMgKAy_xTEUgLHjEZQrkDj-xC8rdXcu1b7F4VBLduqmVomVMuEatlWvbVVi6h-X-8Yy9ZW_8V1zAj8WAM6GN3UXnfGhQ-cFIwIHrnfK-7ZNfblyx9QR5eTOEQ9XekuDHbxrmv_V_FYjqnH63P1dC0x_fOQq2PyCr5NoiM</recordid><startdate>200307</startdate><enddate>200307</enddate><creator>Buchholz, Tina</creator><creator>Thaler, Christian J.</creator><general>Munksgaard International Publishers</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200307</creationdate><title>Inherited Thrombophilia: Impact on Human Reproduction</title><author>Buchholz, Tina ; Thaler, Christian J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4639-872a95edb64553ef3c56817556f456cbe6d1a6d7da62f4802d4ba8cb73717abf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Biological and medical sciences</topic><topic>Blood Coagulation - genetics</topic><topic>Blood Coagulation Factors - genetics</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Female</topic><topic>fibrinolysis</topic><topic>Fibrinolysis - genetics</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>hemostasis</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>placental perfusion</topic><topic>Polymorphism, Genetic</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Hematologic - etiology</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Reproduction - genetics</topic><topic>Thrombophilia - complications</topic><topic>Thrombophilia - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Buchholz, Tina</creatorcontrib><creatorcontrib>Thaler, Christian J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of reproductive immunology (1989)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Buchholz, Tina</au><au>Thaler, Christian J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inherited Thrombophilia: Impact on Human Reproduction</atitle><jtitle>American journal of reproductive immunology (1989)</jtitle><addtitle>Am J Reprod Immunol</addtitle><date>2003-07</date><risdate>2003</risdate><volume>50</volume><issue>1</issue><spage>20</spage><epage>32</epage><pages>20-32</pages><issn>1046-7408</issn><issn>8755-8920</issn><eissn>1600-0897</eissn><abstract>The development of thrombotic disorders is a major threat for young women during pregnancy. It is one of the main causes of pregnancy‐related disorders, which may also result in harm for the conceptus. Successful pregnancies require an even balance of coagulation and fibrinolysis, in order to secure stabilization of the basal plate as well as adequate placental perfusion. Thrombophilia is a laboratory definition for pre‐disposing factors of thrombosis, which can be inherited or acquired. Many individuals, who carry a thrombotic defect remain asymptomatic, at least until additional boosting factors arise. The documentation of thrombophilic causes of recurrent miscarriage or pregnancy‐related disorders is important, because of availability of effective early treatment. There is a rapidly growing awareness on the relationship of genetic factors influencing hemostasis and pregnancy‐related disorders. The aim of our review is to summarize this knowledge, focusing on common genetic variations.</abstract><cop>Oxford, UK</cop><pub>Munksgaard International Publishers</pub><pmid>14506925</pmid><doi>10.1034/j.1600-0897.2003.00049.x</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1046-7408 |
| ispartof | American journal of reproductive immunology (1989), 2003-07, Vol.50 (1), p.20-32 |
| issn | 1046-7408 8755-8920 1600-0897 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Biological and medical sciences Blood Coagulation - genetics Blood Coagulation Factors - genetics Diseases of mother, fetus and pregnancy Female fibrinolysis Fibrinolysis - genetics Gynecology. Andrology. Obstetrics hemostasis Humans Medical sciences placental perfusion Polymorphism, Genetic Pregnancy Pregnancy Complications, Hematologic - etiology Pregnancy. Fetus. Placenta Reproduction - genetics Thrombophilia - complications Thrombophilia - genetics |
| title | Inherited Thrombophilia: Impact on Human Reproduction |
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