Immunology and Endometriosis
Problem: Accumulating data suggests that aberrant immune responses during retrograde menstruation may be involved in the development of endometriosis. Method of Study: The role of immunology in the etiology of endometriosis is reviewed and summarized from the available literature. Results: Immunolog...
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| Veröffentlicht in: | American journal of reproductive immunology (1989) 2003-07, Vol.50 (1), p.48-59 |
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| container_title | American journal of reproductive immunology (1989) |
| container_volume | 50 |
| creator | Berkkanoglu, Murat Arici, Aydin |
| description | Problem: Accumulating data suggests that aberrant immune responses during retrograde menstruation may be involved in the development of endometriosis.
Method of Study: The role of immunology in the etiology of endometriosis is reviewed and summarized from the available literature.
Results: Immunologic factors may affect a woman's susceptibility to implantation of exfoliated endometrial cells. Immune alterations include increased number and activation of peritoneal macrophages, decreased T cell reactivity and natural killer cell cytotoxicity, increased circulating antibodies, and changes in the cytokine network.
Conclusion: There is substantial evidence that immunologic factors play a role in the pathogenesis of endometriosis and endometriosis‐associated infertility. Decreased natural killer cell cytotoxicity leads to an increased likelihood of implantation of endometriotic tissue. In addition, macrophages and a complex network of locally produced cytokines modulate the growth and inflammatory behavior of ectopic endometrial implants. |
| doi_str_mv | 10.1034/j.1600-0897.2003.00042.x |
| format | Article |
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Method of Study: The role of immunology in the etiology of endometriosis is reviewed and summarized from the available literature.
Results: Immunologic factors may affect a woman's susceptibility to implantation of exfoliated endometrial cells. Immune alterations include increased number and activation of peritoneal macrophages, decreased T cell reactivity and natural killer cell cytotoxicity, increased circulating antibodies, and changes in the cytokine network.
Conclusion: There is substantial evidence that immunologic factors play a role in the pathogenesis of endometriosis and endometriosis‐associated infertility. Decreased natural killer cell cytotoxicity leads to an increased likelihood of implantation of endometriotic tissue. In addition, macrophages and a complex network of locally produced cytokines modulate the growth and inflammatory behavior of ectopic endometrial implants.</description><identifier>ISSN: 1046-7408</identifier><identifier>ISSN: 8755-8920</identifier><identifier>EISSN: 1600-0897</identifier><identifier>DOI: 10.1034/j.1600-0897.2003.00042.x</identifier><identifier>PMID: 14506928</identifier><language>eng</language><publisher>Oxford, UK: Munksgaard International Publishers</publisher><subject>Autoimmunity ; Biological and medical sciences ; chemokines ; cytokines ; Endometriosis - etiology ; Endometriosis - immunology ; endometrium ; Female ; Female genital diseases ; Gynecology. Andrology. Obstetrics ; Humans ; macrophage ; Medical sciences ; Menstruation Disturbances - complications ; Menstruation Disturbances - immunology ; Models, Immunological ; natural killer cell ; Non tumoral diseases</subject><ispartof>American journal of reproductive immunology (1989), 2003-07, Vol.50 (1), p.48-59</ispartof><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5292-65fea5890c6151d18396042751296294f1678bb77535d25a3a44854a68913bff3</citedby><cites>FETCH-LOGICAL-c5292-65fea5890c6151d18396042751296294f1678bb77535d25a3a44854a68913bff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1034%2Fj.1600-0897.2003.00042.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1034%2Fj.1600-0897.2003.00042.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14875379$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14506928$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Berkkanoglu, Murat</creatorcontrib><creatorcontrib>Arici, Aydin</creatorcontrib><title>Immunology and Endometriosis</title><title>American journal of reproductive immunology (1989)</title><addtitle>Am J Reprod Immunol</addtitle><description>Problem: Accumulating data suggests that aberrant immune responses during retrograde menstruation may be involved in the development of endometriosis.
Method of Study: The role of immunology in the etiology of endometriosis is reviewed and summarized from the available literature.
Results: Immunologic factors may affect a woman's susceptibility to implantation of exfoliated endometrial cells. Immune alterations include increased number and activation of peritoneal macrophages, decreased T cell reactivity and natural killer cell cytotoxicity, increased circulating antibodies, and changes in the cytokine network.
Conclusion: There is substantial evidence that immunologic factors play a role in the pathogenesis of endometriosis and endometriosis‐associated infertility. Decreased natural killer cell cytotoxicity leads to an increased likelihood of implantation of endometriotic tissue. In addition, macrophages and a complex network of locally produced cytokines modulate the growth and inflammatory behavior of ectopic endometrial implants.</description><subject>Autoimmunity</subject><subject>Biological and medical sciences</subject><subject>chemokines</subject><subject>cytokines</subject><subject>Endometriosis - etiology</subject><subject>Endometriosis - immunology</subject><subject>endometrium</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>macrophage</subject><subject>Medical sciences</subject><subject>Menstruation Disturbances - complications</subject><subject>Menstruation Disturbances - immunology</subject><subject>Models, Immunological</subject><subject>natural killer cell</subject><subject>Non tumoral diseases</subject><issn>1046-7408</issn><issn>8755-8920</issn><issn>1600-0897</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMtKAzEUhoMotlbfQKQb3c14MrmDG6m1VoqCVhQ3IZ3JyNS51EkH27c3taW601UO5PvP5UOoiyHEQOj5NMQcIACpRBgBkBAAaBQudlB7-7Hra6A8EBRkCx04N_WQVETsoxamDLiKZBsdD4uiKau8elt2TZl0-2VSFXZeZ5XL3CHaS03u7NHm7aCn6_64dxOM7gfD3uUoiFmkooCz1BomFcQcM5xgSRT36wiGI8UjRVPMhZxMhGCEJREzxFAqGTVcKkwmaUo66Gzdd1ZXH411c11kLrZ5bkpbNU4LJkBQIf8EsZTAGDAPyjUY15VztU31rM4KUy81Br1SqKd6ZUqvTOmVQv2tUC989GQzo5kUNvkJbpx54HQDGBebPK1NGWfuFyf9oUJ57mLNfWa5Xf57AX15O_SFjwfreObmdrGNm_pdc0EE0893Az16ZC8Pr-Mr3SNf_fKXjw</recordid><startdate>200307</startdate><enddate>200307</enddate><creator>Berkkanoglu, Murat</creator><creator>Arici, Aydin</creator><general>Munksgaard International Publishers</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200307</creationdate><title>Immunology and Endometriosis</title><author>Berkkanoglu, Murat ; Arici, Aydin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5292-65fea5890c6151d18396042751296294f1678bb77535d25a3a44854a68913bff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Autoimmunity</topic><topic>Biological and medical sciences</topic><topic>chemokines</topic><topic>cytokines</topic><topic>Endometriosis - etiology</topic><topic>Endometriosis - immunology</topic><topic>endometrium</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>macrophage</topic><topic>Medical sciences</topic><topic>Menstruation Disturbances - complications</topic><topic>Menstruation Disturbances - immunology</topic><topic>Models, Immunological</topic><topic>natural killer cell</topic><topic>Non tumoral diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Berkkanoglu, Murat</creatorcontrib><creatorcontrib>Arici, Aydin</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of reproductive immunology (1989)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Berkkanoglu, Murat</au><au>Arici, Aydin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunology and Endometriosis</atitle><jtitle>American journal of reproductive immunology (1989)</jtitle><addtitle>Am J Reprod Immunol</addtitle><date>2003-07</date><risdate>2003</risdate><volume>50</volume><issue>1</issue><spage>48</spage><epage>59</epage><pages>48-59</pages><issn>1046-7408</issn><issn>8755-8920</issn><eissn>1600-0897</eissn><abstract>Problem: Accumulating data suggests that aberrant immune responses during retrograde menstruation may be involved in the development of endometriosis.
Method of Study: The role of immunology in the etiology of endometriosis is reviewed and summarized from the available literature.
Results: Immunologic factors may affect a woman's susceptibility to implantation of exfoliated endometrial cells. Immune alterations include increased number and activation of peritoneal macrophages, decreased T cell reactivity and natural killer cell cytotoxicity, increased circulating antibodies, and changes in the cytokine network.
Conclusion: There is substantial evidence that immunologic factors play a role in the pathogenesis of endometriosis and endometriosis‐associated infertility. Decreased natural killer cell cytotoxicity leads to an increased likelihood of implantation of endometriotic tissue. In addition, macrophages and a complex network of locally produced cytokines modulate the growth and inflammatory behavior of ectopic endometrial implants.</abstract><cop>Oxford, UK</cop><pub>Munksgaard International Publishers</pub><pmid>14506928</pmid><doi>10.1034/j.1600-0897.2003.00042.x</doi><tpages>12</tpages></addata></record> |
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| identifier | ISSN: 1046-7408 |
| ispartof | American journal of reproductive immunology (1989), 2003-07, Vol.50 (1), p.48-59 |
| issn | 1046-7408 8755-8920 1600-0897 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals |
| subjects | Autoimmunity Biological and medical sciences chemokines cytokines Endometriosis - etiology Endometriosis - immunology endometrium Female Female genital diseases Gynecology. Andrology. Obstetrics Humans macrophage Medical sciences Menstruation Disturbances - complications Menstruation Disturbances - immunology Models, Immunological natural killer cell Non tumoral diseases |
| title | Immunology and Endometriosis |
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