Increased coronary events in depressed cardiovascular patients: 5-HT2A receptor as missing link?

Major depressive disorder and depressive symptoms have been identified as independent risk factors for cardiac morbidity and mortality in patients with ischemic heart disease. Increased susceptibility to platelet activation has been proposed as one of the mechanisms by which depression acts as a sig...

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Veröffentlicht in:	Psychosomatic medicine 2003-09, Vol.65 (5), p.729-737
Hauptverfasser:	Schins, Annique, Honig, Adriaan, Crijns, Harrie, Baur, Leo, Hamulyák, Karly
Format:	Artikel
Sprache:	eng
Schlagworte:	Antidepressive Agents - pharmacology Antidepressive Agents - therapeutic use Blood Platelets - drug effects Calcium Signaling - genetics Cardiovascular Diseases - blood Cardiovascular Diseases - complications Cardiovascular Diseases - epidemiology Cardiovascular Diseases - genetics Cardiovascular Diseases - psychology Comorbidity Depression - blood Depression - drug therapy Depression - epidemiology Depression - etiology Depression - genetics Depressive Disorder - blood Depressive Disorder - drug therapy Depressive Disorder - epidemiology Depressive Disorder - genetics Genetic Predisposition to Disease Humans Models, Biological Myocardial Ischemia - epidemiology Myocardial Ischemia - etiology Platelet Activation - drug effects Platelet Activation - genetics Platelet Activation - physiology Platelet Aggregation - drug effects Platelet Aggregation - genetics Receptor, Serotonin, 5-HT2A - genetics Receptor, Serotonin, 5-HT2A - physiology Serotonin - pharmacology Thrombophilia - complications Thrombophilia - genetics
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