Tumour necrosis and microvascular proliferation are associated with 9p deletion and CDKN2A alterations in 1p/19q-deleted oligodendrogliomas

A subset of oligodendrogliomas and oligoastrocytomas has been associated with 1p/19q deletion. Subsequently, this genetic alteration was linked to chemosensitivity and classic histology of oligodendrogliomas. Tumoural progression includes deletions of 9p, 10q and alterations of CDKN2A. However, thes...

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Veröffentlicht in:	Neuropathology and applied neurobiology 2003-10, Vol.29 (5), p.462-471
Hauptverfasser:	Godfraind, C., Rousseau, E., Ruchoux, M.-M., Scaravilli, F., Vikkula, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	angiogenesis Biological and medical sciences CDKN2A Central Nervous System Neoplasms - blood supply Central Nervous System Neoplasms - genetics Central Nervous System Neoplasms - pathology Chromosomes, Human, Pair 1 Chromosomes, Human, Pair 19 Chromosomes, Human, Pair 9 - genetics deletion Gene Deletion Genes, p16 genetic Glioma - classification Glioma - genetics Glioma - pathology Humans Loss of Heterozygosity - genetics Medical sciences Methylation Microsatellite Repeats microvascular proliferation mutation Necrosis Neurology oligodendroglioma Oligodendroglioma - blood supply Oligodendroglioma - genetics Oligodendroglioma - pathology Polymerase Chain Reaction Polymorphism, Single-Stranded Conformational Promoter Regions, Genetic Tumors of the nervous system. Phacomatoses
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