Presence of the brown fat-specific mitochondrial uncoupling protein and iodothyronine 5'-deiodinase activity in subcutaneous adipose tissue of neonatal lambs
Subcutaneous adipose tissue of neonatal lambs has been examined for the presence of markers diagnostic of thermogenic brown fat. Uncoupling protein, uncoupling protein mRNA, and iodothyronine 5'-deiodinase activity were each detected in subcutaneous adipose tissue, as well as in the major inter...
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| Veröffentlicht in: | FEBS letters 1993-05, Vol.322 (1), p.76-78 |
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| creator | Trayhurn, Paul Thomas, Moira E.A. Duncan, Jacqueline S. Nicol, Fergus Arthur, John R. |
| description | Subcutaneous adipose tissue of neonatal lambs has been examined for the presence of markers diagnostic of thermogenic brown fat. Uncoupling protein, uncoupling protein mRNA, and iodothyronine 5'-deiodinase activity were each detected in subcutaneous adipose tissue, as well as in the major internal fat depot (perirenal), of newborn lambs. These brown fat markers were not present, however, in adipose tissue of adult sheep. It is concluded that subcutaneous fat in newborn lambs is functionally ‘brown’, and similar to the internal fat; subcutaneous and internal adipose tissues follow a similar developmental path - from ‘brown’ to ‘white’. |
| doi_str_mv | 10.1016/0014-5793(93)81115-G |
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Uncoupling protein, uncoupling protein mRNA, and iodothyronine 5'-deiodinase activity were each detected in subcutaneous adipose tissue, as well as in the major internal fat depot (perirenal), of newborn lambs. These brown fat markers were not present, however, in adipose tissue of adult sheep. 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Psychology ; Iodide Peroxidase - metabolism ; Iodothyronine 5'-deiodinase ; Ion Channels ; Membrane Proteins - metabolism ; Mitochondrial Proteins ; Molecular Sequence Data ; Northern blotting ; Oligodeoxyribonucleotides ; Sheep ; Uncoupling Agents - metabolism ; Uncoupling protein ; Uncoupling Protein 1 ; Vertebrates: skin, associated glands, phaneres, light organs, various exocrine glands (salt gland, uropygial gland...), adipose tissue, connective tissue ; Western blotting ; White adipose tissue</subject><ispartof>FEBS letters, 1993-05, Vol.322 (1), p.76-78</ispartof><rights>1993</rights><rights>FEBS Letters 322 (1993) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c495G-93453a77a27d1c3a80f5f6f87081a254ea2087c83698941dce50cbb427e39e4e3</citedby><cites>FETCH-LOGICAL-c495G-93453a77a27d1c3a80f5f6f87081a254ea2087c83698941dce50cbb427e39e4e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0014-5793(93)81115-G$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4705985$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8482372$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Trayhurn, Paul</creatorcontrib><creatorcontrib>Thomas, Moira E.A.</creatorcontrib><creatorcontrib>Duncan, Jacqueline S.</creatorcontrib><creatorcontrib>Nicol, Fergus</creatorcontrib><creatorcontrib>Arthur, John R.</creatorcontrib><title>Presence of the brown fat-specific mitochondrial uncoupling protein and iodothyronine 5'-deiodinase activity in subcutaneous adipose tissue of neonatal lambs</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>Subcutaneous adipose tissue of neonatal lambs has been examined for the presence of markers diagnostic of thermogenic brown fat. Uncoupling protein, uncoupling protein mRNA, and iodothyronine 5'-deiodinase activity were each detected in subcutaneous adipose tissue, as well as in the major internal fat depot (perirenal), of newborn lambs. These brown fat markers were not present, however, in adipose tissue of adult sheep. It is concluded that subcutaneous fat in newborn lambs is functionally ‘brown’, and similar to the internal fat; subcutaneous and internal adipose tissues follow a similar developmental path - from ‘brown’ to ‘white’.</description><subject>Adipose Tissue - enzymology</subject><subject>Adipose Tissue - metabolism</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Brown adipose tissue</subject><subject>Carrier Proteins - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Iodide Peroxidase - metabolism</subject><subject>Iodothyronine 5'-deiodinase</subject><subject>Ion Channels</subject><subject>Membrane Proteins - metabolism</subject><subject>Mitochondrial Proteins</subject><subject>Molecular Sequence Data</subject><subject>Northern blotting</subject><subject>Oligodeoxyribonucleotides</subject><subject>Sheep</subject><subject>Uncoupling Agents - metabolism</subject><subject>Uncoupling protein</subject><subject>Uncoupling Protein 1</subject><subject>Vertebrates: skin, associated glands, phaneres, light organs, various exocrine glands (salt gland, uropygial gland...), adipose tissue, connective tissue</subject><subject>Western blotting</subject><subject>White adipose tissue</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkt2KEzEUxwdR1u7qGyjkQly9GE0mSZO5EXTZVmFBL_Q6ZDJn7JFpUpPMLn0Y39VMW3opQiDkf37nO1X1gtF3jLLle0qZqKVq-ZuWv9WMMVmvH1ULphWvuVjqx9XijDytLlP6Rctbs_aiutBCN1w1i-rPtwgJvAMSBpI3QLoYHjwZbK7TDhwO6MgWc3Cb4PuIdiSTd2Hajeh_kl0MGdAT63uCoQ95s4_Bowcir-seioTeJiDWZbzHvCeFTVPnpmw9hCkR2-MuFCBjStOhhKJ7m0ua0W679Kx6MtgxwfPTfVX9WN1-v_lc331df7n5eFc70cp13XIhuVXKNqpnjltNBzksB62oZraRAmxDtXKaL1vdCtY7kNR1nWgU8BYE8Kvq9TFu6ej3BCmbLSYH43is0yipqKR6WUBxBF0MKUUYzC7i1sa9YdTMWzHzyM08clPOYStmXdxenuJP3Rb6s9NpDcX-6mS3ydlxiNY7TGdMlOytlgVbHbEHHGH_X6nN6vZTMxtmveUHda7nwzEQlKHeI0STHM6_oMcILps-4L8b-gsd9L94</recordid><startdate>19930503</startdate><enddate>19930503</enddate><creator>Trayhurn, Paul</creator><creator>Thomas, Moira E.A.</creator><creator>Duncan, Jacqueline S.</creator><creator>Nicol, Fergus</creator><creator>Arthur, John R.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19930503</creationdate><title>Presence of the brown fat-specific mitochondrial uncoupling protein and iodothyronine 5'-deiodinase activity in subcutaneous adipose tissue of neonatal lambs</title><author>Trayhurn, Paul ; Thomas, Moira E.A. ; Duncan, Jacqueline S. ; Nicol, Fergus ; Arthur, John R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c495G-93453a77a27d1c3a80f5f6f87081a254ea2087c83698941dce50cbb427e39e4e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adipose Tissue - enzymology</topic><topic>Adipose Tissue - metabolism</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Brown adipose tissue</topic><topic>Carrier Proteins - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Iodide Peroxidase - metabolism</topic><topic>Iodothyronine 5'-deiodinase</topic><topic>Ion Channels</topic><topic>Membrane Proteins - metabolism</topic><topic>Mitochondrial Proteins</topic><topic>Molecular Sequence Data</topic><topic>Northern blotting</topic><topic>Oligodeoxyribonucleotides</topic><topic>Sheep</topic><topic>Uncoupling Agents - metabolism</topic><topic>Uncoupling protein</topic><topic>Uncoupling Protein 1</topic><topic>Vertebrates: skin, associated glands, phaneres, light organs, various exocrine glands (salt gland, uropygial gland...), adipose tissue, connective tissue</topic><topic>Western blotting</topic><topic>White adipose tissue</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Trayhurn, Paul</creatorcontrib><creatorcontrib>Thomas, Moira E.A.</creatorcontrib><creatorcontrib>Duncan, Jacqueline S.</creatorcontrib><creatorcontrib>Nicol, Fergus</creatorcontrib><creatorcontrib>Arthur, John R.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Trayhurn, Paul</au><au>Thomas, Moira E.A.</au><au>Duncan, Jacqueline S.</au><au>Nicol, Fergus</au><au>Arthur, John R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Presence of the brown fat-specific mitochondrial uncoupling protein and iodothyronine 5'-deiodinase activity in subcutaneous adipose tissue of neonatal lambs</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>1993-05-03</date><risdate>1993</risdate><volume>322</volume><issue>1</issue><spage>76</spage><epage>78</epage><pages>76-78</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><coden>FEBLAL</coden><abstract>Subcutaneous adipose tissue of neonatal lambs has been examined for the presence of markers diagnostic of thermogenic brown fat. Uncoupling protein, uncoupling protein mRNA, and iodothyronine 5'-deiodinase activity were each detected in subcutaneous adipose tissue, as well as in the major internal fat depot (perirenal), of newborn lambs. These brown fat markers were not present, however, in adipose tissue of adult sheep. It is concluded that subcutaneous fat in newborn lambs is functionally ‘brown’, and similar to the internal fat; subcutaneous and internal adipose tissues follow a similar developmental path - from ‘brown’ to ‘white’.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>8482372</pmid><doi>10.1016/0014-5793(93)81115-G</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | FEBS letters, 1993-05, Vol.322 (1), p.76-78 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adipose Tissue - enzymology Adipose Tissue - metabolism Animals Animals, Newborn Base Sequence Biological and medical sciences Brown adipose tissue Carrier Proteins - metabolism Fundamental and applied biological sciences. Psychology Iodide Peroxidase - metabolism Iodothyronine 5'-deiodinase Ion Channels Membrane Proteins - metabolism Mitochondrial Proteins Molecular Sequence Data Northern blotting Oligodeoxyribonucleotides Sheep Uncoupling Agents - metabolism Uncoupling protein Uncoupling Protein 1 Vertebrates: skin, associated glands, phaneres, light organs, various exocrine glands (salt gland, uropygial gland...), adipose tissue, connective tissue Western blotting White adipose tissue |
| title | Presence of the brown fat-specific mitochondrial uncoupling protein and iodothyronine 5'-deiodinase activity in subcutaneous adipose tissue of neonatal lambs |
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