Substitution of the structural genes of dengue virus type 4 with those of type 2 results in chimeric vaccine candidates which are attenuated for mosquitoes, mice, and rhesus monkeys

Antigenic chimeric viruses in which the structural genes of dengue virus type 4 (DEN4) have been replaced with those derived from dengue virus type 2 (DEN2) have been created and evaluated as a first step in generating a live attenuated tetravalent dengue virus vaccine. Specifically, the capsid, mem...

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Veröffentlicht in:	Vaccine 2003-10, Vol.21 (27), p.4307-4316
Hauptverfasser:	Whitehead, Stephen S, Hanley, Kathryn A, Blaney, Joseph E, Gilmore, Lara E, Elkins, William R, Murphy, Brian R
Format:	Artikel
Sprache:	eng
Schlagworte:	Aedes Amino Acid Sequence Animals Aquatic insects Base Sequence Biological and medical sciences Cercopithecus aethiops Chimerization Culicidae Culicidae - virology Dengue Dengue fever Dengue Virus - genetics Dengue virus type 2 Dengue virus type 4 Fundamental and applied biological sciences. Psychology Genes Immunogenicity Macaca mulatta Mice Mice, SCID Microbiology Molecular Sequence Data Mosquitoes Mutation Mutation - genetics Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - immunology Vaccination Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Vaccines, Attenuated - genetics Vaccines, Attenuated - immunology Vector-borne diseases Vero Cells Viral Vaccines - genetics Viral Vaccines - immunology Virology Virus Replication - genetics
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