Determination of amphetamine, methamphetamine and desmethyldeprenyl in human plasma by gas chromatography/negative ion chemical ionization mass spectrometry
A sensitive and specific assay for the quantitative determination of amphetamine, methamphetamine and desmethyldeprenyl in human plasma specimens is described. Electron capture/negative ion chemical ionization gas chromatography/mass spectrometry is used to determine the extracted plasma concentrati...
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| Veröffentlicht in: | Biological Mass Spectrometry 1993-04, Vol.22 (4), p.235-242 |
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| container_title | Biological Mass Spectrometry |
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| creator | Reimer, Mark L. J. Mamer, Orval A. Zavitsanos, A. Paul Siddiqui, A. Waheed Dadgar, D. |
| description | A sensitive and specific assay for the quantitative determination of amphetamine, methamphetamine and desmethyldeprenyl in human plasma specimens is described. Electron capture/negative ion chemical ionization gas chromatography/mass spectrometry is used to determine the extracted plasma concentrations of the three target compounds as their N‐heptafluorobutyryl derivatives. Quantitation is performed by stable isotope dilution using d6‐amphetamine and d6‐methamphetamine as internal standards. Selected ion monitoring of the [M – HF]− ions of both the analytes and internal standards results in minimum quantifiable limits of 0.10 ng ml−1 for both amphetamine and methamphetamine and 0.25 ng ml−1 for desmethyldeprenyl. Excellent linearity (r = 0.998) up to at least 5.00 ng ml−1 is demonstrated. |
| doi_str_mv | 10.1002/bms.1200220404 |
| format | Article |
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J.</creatorcontrib><creatorcontrib>Mamer, Orval A.</creatorcontrib><creatorcontrib>Zavitsanos, A. Paul</creatorcontrib><creatorcontrib>Siddiqui, A. Waheed</creatorcontrib><creatorcontrib>Dadgar, D.</creatorcontrib><title>Determination of amphetamine, methamphetamine and desmethyldeprenyl in human plasma by gas chromatography/negative ion chemical ionization mass spectrometry</title><title>Biological Mass Spectrometry</title><addtitle>Biol. Mass Spectrom</addtitle><description>A sensitive and specific assay for the quantitative determination of amphetamine, methamphetamine and desmethyldeprenyl in human plasma specimens is described. Electron capture/negative ion chemical ionization gas chromatography/mass spectrometry is used to determine the extracted plasma concentrations of the three target compounds as their N‐heptafluorobutyryl derivatives. Quantitation is performed by stable isotope dilution using d6‐amphetamine and d6‐methamphetamine as internal standards. Selected ion monitoring of the [M – HF]− ions of both the analytes and internal standards results in minimum quantifiable limits of 0.10 ng ml−1 for both amphetamine and methamphetamine and 0.25 ng ml−1 for desmethyldeprenyl. Excellent linearity (r = 0.998) up to at least 5.00 ng ml−1 is demonstrated.</description><subject>Amphetamine - blood</subject><subject>Analysis</subject><subject>Biological and medical sciences</subject><subject>Gas Chromatography-Mass Spectrometry</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Methamphetamine - blood</subject><subject>Pharmacology. Drug treatments</subject><subject>Quality Control</subject><subject>Regression Analysis</subject><subject>Selegiline - analogs & derivatives</subject><subject>Selegiline - blood</subject><issn>1052-9306</issn><issn>1096-9888</issn><issn>2376-3876</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUcGO0zAQjRBoWQpXbkg-IE6ka8d24hxpgV1EAQkWcbQmzqQJxEnWToHwLXwsjlIVOO3J4zfvzbPnRdFjRteM0uSisH7NklAlVFBxJzpnNE_jXCl1d65lEuecpvejB95_pZSrIDqLzpRQTDB2Hv1-iSM623QwNn1H-oqAHWocIUD4nFgc638AAl1JSvQzPLUlDg67qSVNR-qDhY4MLXgLpJjIHjwxtestjP3ewVBPFx3ug8l3JLORqdE2Btr50vxazC14T_yAZgw6HN30MLpXQevx0fFcRZ9fv7reXsW7D5dvti92sRFciVgmnKGkZRH-VuUShVAgGBVGFnmihKFlxljJTQEogEIJLMOC5iLBokpzWfJV9GyZO7j-5oB-1LbxBtsWOuwPXmcyo5wydiuRpZJKFda8itYL0bjee4eVHlxjwU2aUT3npkNu-m9uQfDkOPlQWCxP9GNQof_02Acf1lY56EzjTzSRKq5oGmj5QvvRtDjdYqo37z7994R40TZ-xJ8nLbhvOs14JvWX95f67faj2lxtrvWO_wEYD8Qw</recordid><startdate>199304</startdate><enddate>199304</enddate><creator>Reimer, Mark L. 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Waheed ; Dadgar, D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4384-5231e50db100f95e448a4104c5b9284c0d711d3cbae4a0ada17eb0942ebf695d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Amphetamine - blood</topic><topic>Analysis</topic><topic>Biological and medical sciences</topic><topic>Gas Chromatography-Mass Spectrometry</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Methamphetamine - blood</topic><topic>Pharmacology. Drug treatments</topic><topic>Quality Control</topic><topic>Regression Analysis</topic><topic>Selegiline - analogs & derivatives</topic><topic>Selegiline - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Reimer, Mark L. J.</creatorcontrib><creatorcontrib>Mamer, Orval A.</creatorcontrib><creatorcontrib>Zavitsanos, A. 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Quantitation is performed by stable isotope dilution using d6‐amphetamine and d6‐methamphetamine as internal standards. Selected ion monitoring of the [M – HF]− ions of both the analytes and internal standards results in minimum quantifiable limits of 0.10 ng ml−1 for both amphetamine and methamphetamine and 0.25 ng ml−1 for desmethyldeprenyl. Excellent linearity (r = 0.998) up to at least 5.00 ng ml−1 is demonstrated.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>8481411</pmid><doi>10.1002/bms.1200220404</doi><tpages>8</tpages></addata></record> |
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| ispartof | Biological Mass Spectrometry, 1993-04, Vol.22 (4), p.235-242 |
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| language | eng |
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| source | MEDLINE; Access via Wiley Online Library; Alma/SFX Local Collection |
| subjects | Amphetamine - blood Analysis Biological and medical sciences Gas Chromatography-Mass Spectrometry General pharmacology Humans Medical sciences Methamphetamine - blood Pharmacology. Drug treatments Quality Control Regression Analysis Selegiline - analogs & derivatives Selegiline - blood |
| title | Determination of amphetamine, methamphetamine and desmethyldeprenyl in human plasma by gas chromatography/negative ion chemical ionization mass spectrometry |
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