Infant stroke and beta-2-glycoprotein 1 antibodies: six cases
The binding of autoimmune anticardiolipin antibodies to phospholipid has been shown to require a plasma cofactor, beta-2-glycoprotein 1 (beta2-GPI). Antibodies against beta2-GPI are associated with both venous and arterial thrombosis in adults and have been suggested as a new antiphospholipid syndro...
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| Veröffentlicht in: | European journal of pediatrics 2003-10, Vol.162 (10), p.678-681 |
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| container_title | European journal of pediatrics |
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| creator | EBELING, Freja PETÄJÄ, Jari ALANKO, Soile HIRVASNIEMI, Aune HOLM, Tarja LÄHDE, Marja NUUTILA, Auli PESONEN, Helena VAHTERA, Elina RASI, Vesa |
| description | The binding of autoimmune anticardiolipin antibodies to phospholipid has been shown to require a plasma cofactor, beta-2-glycoprotein 1 (beta2-GPI). Antibodies against beta2-GPI are associated with both venous and arterial thrombosis in adults and have been suggested as a new antiphospholipid syndrome marker. We present six children with cerebral thrombosis at the age of 0-12 months, who had IgG antibodies to beta2-GPI (titers 26, 29, 31, 39, 101 and 109 SGU, when 20 SGU was the cut-off). In at least four patients, the conventional antiphospholipid markers (lupus anticoagulant and IgG and IgM anticardiolipin) were negative. All six children had normal results in the other routine thrombophilia assays (thrombin time, antithrombin, protein C, protein S, factor V Leiden mutation, prothrombin mutation).
the anti-beta-2 glycoprotein 1 assay, requiring only 5 microl serum, may be a useful addition to antiphospholipid-antibody diagnostics in cases of paediatric stroke. |
| doi_str_mv | 10.1007/s00431-003-1285-9 |
| format | Article |
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the anti-beta-2 glycoprotein 1 assay, requiring only 5 microl serum, may be a useful addition to antiphospholipid-antibody diagnostics in cases of paediatric stroke.</description><identifier>ISSN: 0340-6199</identifier><identifier>EISSN: 1432-1076</identifier><identifier>DOI: 10.1007/s00431-003-1285-9</identifier><identifier>PMID: 12915983</identifier><identifier>CODEN: EJPEDT</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Antibodies, Anticardiolipin - immunology ; beta 2-Glycoprotein I ; Biological and medical sciences ; Female ; Fundamental and applied biological sciences. Psychology ; General aspects ; Genetics of eukaryotes. Biological and molecular evolution ; Glycoproteins - immunology ; Humans ; Infant ; Intracranial Thrombosis - immunology ; Male ; Medical sciences ; Membrane Glycoproteins - immunology ; Molecular and cellular biology ; Stroke - immunology</subject><ispartof>European journal of pediatrics, 2003-10, Vol.162 (10), p.678-681</ispartof><rights>2004 INIST-CNRS</rights><rights>Springer-Verlag 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-964e11b97939a87ee9128196ea06f0cc3b71f74b7d0ff74f09c37efc591f8fbe3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15165895$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12915983$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>EBELING, Freja</creatorcontrib><creatorcontrib>PETÄJÄ, Jari</creatorcontrib><creatorcontrib>ALANKO, Soile</creatorcontrib><creatorcontrib>HIRVASNIEMI, Aune</creatorcontrib><creatorcontrib>HOLM, Tarja</creatorcontrib><creatorcontrib>LÄHDE, Marja</creatorcontrib><creatorcontrib>NUUTILA, Auli</creatorcontrib><creatorcontrib>PESONEN, Helena</creatorcontrib><creatorcontrib>VAHTERA, Elina</creatorcontrib><creatorcontrib>RASI, Vesa</creatorcontrib><title>Infant stroke and beta-2-glycoprotein 1 antibodies: six cases</title><title>European journal of pediatrics</title><addtitle>Eur J Pediatr</addtitle><description>The binding of autoimmune anticardiolipin antibodies to phospholipid has been shown to require a plasma cofactor, beta-2-glycoprotein 1 (beta2-GPI). Antibodies against beta2-GPI are associated with both venous and arterial thrombosis in adults and have been suggested as a new antiphospholipid syndrome marker. We present six children with cerebral thrombosis at the age of 0-12 months, who had IgG antibodies to beta2-GPI (titers 26, 29, 31, 39, 101 and 109 SGU, when 20 SGU was the cut-off). In at least four patients, the conventional antiphospholipid markers (lupus anticoagulant and IgG and IgM anticardiolipin) were negative. All six children had normal results in the other routine thrombophilia assays (thrombin time, antithrombin, protein C, protein S, factor V Leiden mutation, prothrombin mutation).
the anti-beta-2 glycoprotein 1 assay, requiring only 5 microl serum, may be a useful addition to antiphospholipid-antibody diagnostics in cases of paediatric stroke.</description><subject>Antibodies, Anticardiolipin - immunology</subject><subject>beta 2-Glycoprotein I</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Glycoproteins - immunology</subject><subject>Humans</subject><subject>Infant</subject><subject>Intracranial Thrombosis - immunology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Membrane Glycoproteins - immunology</subject><subject>Molecular and cellular biology</subject><subject>Stroke - immunology</subject><issn>0340-6199</issn><issn>1432-1076</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkE1Lw0AQhhdRbP34AV4kCHpbnckm2YzgQcSPQsGLnpfNdlZS06RmU7D_3i0tFDzNYZ535uUR4gLhFgH0XQDIFEoAJTEtc0kHYoyZSiWCLg7FGFQGskCikTgJYQ4xQ1geixGmhDmVaiweJq237ZCEoe--ObHtLKl4sDKVX83adcu-G7huE4yboa66Wc3hPgn1b-Js4HAmjrxtAp_v5qn4fHn-eHqT0_fXydPjVDqVF4OkImPEijQpsqVmplgXqWALhQfnVKXR66zSM_BxeiCnNHuXE_rSV6xOxc32buzzs-IwmEUdHDeNbblbBaNzDakCFcGrf-C8W_Vt7GbSFAmLPNMRwi3k-i6Enr1Z9vXC9muDYDZizVasiWLNRqyhmLncHV5VC57tEzuTEbjeATY42_jetq4Oey6Pv0vK1R_9Nn6A</recordid><startdate>20031001</startdate><enddate>20031001</enddate><creator>EBELING, Freja</creator><creator>PETÄJÄ, Jari</creator><creator>ALANKO, Soile</creator><creator>HIRVASNIEMI, Aune</creator><creator>HOLM, Tarja</creator><creator>LÄHDE, Marja</creator><creator>NUUTILA, Auli</creator><creator>PESONEN, Helena</creator><creator>VAHTERA, Elina</creator><creator>RASI, Vesa</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20031001</creationdate><title>Infant stroke and beta-2-glycoprotein 1 antibodies: six cases</title><author>EBELING, Freja ; PETÄJÄ, Jari ; ALANKO, Soile ; HIRVASNIEMI, Aune ; HOLM, Tarja ; LÄHDE, Marja ; NUUTILA, Auli ; PESONEN, Helena ; VAHTERA, Elina ; RASI, Vesa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-964e11b97939a87ee9128196ea06f0cc3b71f74b7d0ff74f09c37efc591f8fbe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Antibodies, Anticardiolipin - immunology</topic><topic>beta 2-Glycoprotein I</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General aspects</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Glycoproteins - immunology</topic><topic>Humans</topic><topic>Infant</topic><topic>Intracranial Thrombosis - immunology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Membrane Glycoproteins - immunology</topic><topic>Molecular and cellular biology</topic><topic>Stroke - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>EBELING, Freja</creatorcontrib><creatorcontrib>PETÄJÄ, Jari</creatorcontrib><creatorcontrib>ALANKO, Soile</creatorcontrib><creatorcontrib>HIRVASNIEMI, Aune</creatorcontrib><creatorcontrib>HOLM, Tarja</creatorcontrib><creatorcontrib>LÄHDE, Marja</creatorcontrib><creatorcontrib>NUUTILA, Auli</creatorcontrib><creatorcontrib>PESONEN, Helena</creatorcontrib><creatorcontrib>VAHTERA, Elina</creatorcontrib><creatorcontrib>RASI, Vesa</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>EBELING, Freja</au><au>PETÄJÄ, Jari</au><au>ALANKO, Soile</au><au>HIRVASNIEMI, Aune</au><au>HOLM, Tarja</au><au>LÄHDE, Marja</au><au>NUUTILA, Auli</au><au>PESONEN, Helena</au><au>VAHTERA, Elina</au><au>RASI, Vesa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Infant stroke and beta-2-glycoprotein 1 antibodies: six cases</atitle><jtitle>European journal of pediatrics</jtitle><addtitle>Eur J Pediatr</addtitle><date>2003-10-01</date><risdate>2003</risdate><volume>162</volume><issue>10</issue><spage>678</spage><epage>681</epage><pages>678-681</pages><issn>0340-6199</issn><eissn>1432-1076</eissn><coden>EJPEDT</coden><abstract>The binding of autoimmune anticardiolipin antibodies to phospholipid has been shown to require a plasma cofactor, beta-2-glycoprotein 1 (beta2-GPI). Antibodies against beta2-GPI are associated with both venous and arterial thrombosis in adults and have been suggested as a new antiphospholipid syndrome marker. We present six children with cerebral thrombosis at the age of 0-12 months, who had IgG antibodies to beta2-GPI (titers 26, 29, 31, 39, 101 and 109 SGU, when 20 SGU was the cut-off). In at least four patients, the conventional antiphospholipid markers (lupus anticoagulant and IgG and IgM anticardiolipin) were negative. All six children had normal results in the other routine thrombophilia assays (thrombin time, antithrombin, protein C, protein S, factor V Leiden mutation, prothrombin mutation).
the anti-beta-2 glycoprotein 1 assay, requiring only 5 microl serum, may be a useful addition to antiphospholipid-antibody diagnostics in cases of paediatric stroke.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><pub>Springer</pub><pmid>12915983</pmid><doi>10.1007/s00431-003-1285-9</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0340-6199 |
| ispartof | European journal of pediatrics, 2003-10, Vol.162 (10), p.678-681 |
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| subjects | Antibodies, Anticardiolipin - immunology beta 2-Glycoprotein I Biological and medical sciences Female Fundamental and applied biological sciences. Psychology General aspects Genetics of eukaryotes. Biological and molecular evolution Glycoproteins - immunology Humans Infant Intracranial Thrombosis - immunology Male Medical sciences Membrane Glycoproteins - immunology Molecular and cellular biology Stroke - immunology |
| title | Infant stroke and beta-2-glycoprotein 1 antibodies: six cases |
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