Activity-dependent expression of the transcription factor Zif268 reveals ocular dominance columns in monkey visual cortex
The visualization of neuronal populations activated by sensory stimulation has been approached using a number of different methodologies. Recent developments in our understanding of trancription factors have provided a new window for observing neural activity. We have found that the transcription fa...
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| Veröffentlicht in: | Brain research 1993-03, Vol.605 (2), p.349-353 |
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| creator | Chaudhuri, Avi Cynader, Max S. |
| description | The visualization of neuronal populations activated by sensory stimulation has been approached using a number of different methodologies. Recent developments in our understanding of trancription factors have provided a new window for observing neural activity. We have found that the transcription factor Zif268 is expressed throughout the visual cortex of the monkey at high basal levels and that monocular visual deprivation produces dramatic changes in its levels revealing ocular dominance columns in striate cortex with as little as 2 h of selective exposure. These results show that immunodetection for Zif268 may be used for labelling activated neuronal populations in the monkey with several key advantages over prior techniques. |
| doi_str_mv | 10.1016/0006-8993(93)91765-K |
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Visual pathways and centers. Vision</topic><topic>Fos</topic><topic>Fundamental and applied biological sciences. 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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Biological and medical sciences Cercopithecus aethiops Cytochrome oxidase DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - genetics Dominance, Cerebral - physiology Eye - innervation Eye and associated structures. Visual pathways and centers. Vision Fos Fundamental and applied biological sciences. Psychology Immediate-early gene Immunohistochemistry Krox-24 NGFI-A Photic Stimulation Transcription Factors - biosynthesis Transcription Factors - genetics Vertebrates: nervous system and sense organs Vervet Visual Cortex - physiology Zinc Fingers |
| title | Activity-dependent expression of the transcription factor Zif268 reveals ocular dominance columns in monkey visual cortex |
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