Small-cell carcinoma manifesting systemic lymphadenopathy combined with adenocarcinoma in the gallbladder: aggressiveness and sensitivity to chemotherapy
Small-cell carcinoma of the gallbladder is a very rare tumor. In this report, we describe a patient with small-cell carcinoma combined with adenocarcinoma in the gallbladder. The patient was a 70-year-old man, who clinically manifested systemic lymphadenopathy. An incisional biopsy of Virchow's...
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| Veröffentlicht in: | Journal of gastroenterology 2003-08, Vol.38 (8), p.801-805 |
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| creator | Okamoto, Hirotaka Miura, Kazuo Ogawara, Tadahiko Fujii, Hideki Matsumoto, Yoshiro |
| description | Small-cell carcinoma of the gallbladder is a very rare tumor. In this report, we describe a patient with small-cell carcinoma combined with adenocarcinoma in the gallbladder. The patient was a 70-year-old man, who clinically manifested systemic lymphadenopathy. An incisional biopsy of Virchow's lymph node revealed small-cell carcinoma. Abdominal computed tomography (CT) showed massive multiple paraaortic lymph node swelling and a round mass in the gallbladder, although chest CT did not show any abnormal masses in the lung. After two courses of chemotherapy (PVP therapy; cisplatin [CDDP], 80 mg/m(2), day 1, intravenous injection; and etoposide [VP-16], 50 mg/m(2), every day, per oral intake; given every 3 weeks) were performed, the systemic lymphadenopathy had completely diminished and only the gallbladder tumor remained on clinical examinations. Endoscopic retrograde cholangiopancreatography (ERCP) revealed nodular tumors in the gallbladder fundus. Cholecystectomy with partial resection of the liver was performed. Pathological examination revealed small-cell carcinoma combined with adenocarcinoma of the gallbladder. We discuss the characteristics and the treatment of this rare tumor. |
| doi_str_mv | 10.1007/s00535-002-1150-z |
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In this report, we describe a patient with small-cell carcinoma combined with adenocarcinoma in the gallbladder. The patient was a 70-year-old man, who clinically manifested systemic lymphadenopathy. An incisional biopsy of Virchow's lymph node revealed small-cell carcinoma. Abdominal computed tomography (CT) showed massive multiple paraaortic lymph node swelling and a round mass in the gallbladder, although chest CT did not show any abnormal masses in the lung. After two courses of chemotherapy (PVP therapy; cisplatin [CDDP], 80 mg/m(2), day 1, intravenous injection; and etoposide [VP-16], 50 mg/m(2), every day, per oral intake; given every 3 weeks) were performed, the systemic lymphadenopathy had completely diminished and only the gallbladder tumor remained on clinical examinations. Endoscopic retrograde cholangiopancreatography (ERCP) revealed nodular tumors in the gallbladder fundus. Cholecystectomy with partial resection of the liver was performed. Pathological examination revealed small-cell carcinoma combined with adenocarcinoma of the gallbladder. We discuss the characteristics and the treatment of this rare tumor.</description><identifier>ISSN: 0944-1174</identifier><identifier>EISSN: 1435-5922</identifier><identifier>DOI: 10.1007/s00535-002-1150-z</identifier><identifier>PMID: 14505138</identifier><language>eng</language><publisher>Japan: Springer Nature B.V</publisher><subject>Adenocarcinoma - diagnosis ; Adenocarcinoma - drug therapy ; Aged ; Carcinoma, Small Cell - diagnosis ; Carcinoma, Small Cell - drug therapy ; Gallbladder Neoplasms - diagnosis ; Gallbladder Neoplasms - drug therapy ; Humans ; Lymphatic Diseases - etiology ; Male ; Neoplasm Invasiveness ; Neoplasms, Multiple Primary - diagnosis ; Neoplasms, Multiple Primary - drug therapy</subject><ispartof>Journal of gastroenterology, 2003-08, Vol.38 (8), p.801-805</ispartof><rights>Copyright Springer-Verlag 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-2b6b46fb182ac285f9fdc668e354a942253ff76b8d8f4c1815384181c1e62d1f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14505138$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Okamoto, Hirotaka</creatorcontrib><creatorcontrib>Miura, Kazuo</creatorcontrib><creatorcontrib>Ogawara, Tadahiko</creatorcontrib><creatorcontrib>Fujii, Hideki</creatorcontrib><creatorcontrib>Matsumoto, Yoshiro</creatorcontrib><title>Small-cell carcinoma manifesting systemic lymphadenopathy combined with adenocarcinoma in the gallbladder: aggressiveness and sensitivity to chemotherapy</title><title>Journal of gastroenterology</title><addtitle>J Gastroenterol</addtitle><description>Small-cell carcinoma of the gallbladder is a very rare tumor. In this report, we describe a patient with small-cell carcinoma combined with adenocarcinoma in the gallbladder. The patient was a 70-year-old man, who clinically manifested systemic lymphadenopathy. An incisional biopsy of Virchow's lymph node revealed small-cell carcinoma. Abdominal computed tomography (CT) showed massive multiple paraaortic lymph node swelling and a round mass in the gallbladder, although chest CT did not show any abnormal masses in the lung. After two courses of chemotherapy (PVP therapy; cisplatin [CDDP], 80 mg/m(2), day 1, intravenous injection; and etoposide [VP-16], 50 mg/m(2), every day, per oral intake; given every 3 weeks) were performed, the systemic lymphadenopathy had completely diminished and only the gallbladder tumor remained on clinical examinations. Endoscopic retrograde cholangiopancreatography (ERCP) revealed nodular tumors in the gallbladder fundus. Cholecystectomy with partial resection of the liver was performed. Pathological examination revealed small-cell carcinoma combined with adenocarcinoma of the gallbladder. 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| subjects | Adenocarcinoma - diagnosis Adenocarcinoma - drug therapy Aged Carcinoma, Small Cell - diagnosis Carcinoma, Small Cell - drug therapy Gallbladder Neoplasms - diagnosis Gallbladder Neoplasms - drug therapy Humans Lymphatic Diseases - etiology Male Neoplasm Invasiveness Neoplasms, Multiple Primary - diagnosis Neoplasms, Multiple Primary - drug therapy |
| title | Small-cell carcinoma manifesting systemic lymphadenopathy combined with adenocarcinoma in the gallbladder: aggressiveness and sensitivity to chemotherapy |
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