Relationship between delayed diagnosis and the degree of invasion and survival in lung cancer
The aim of this study is to evaluate the relationship between the interval from first symptom to diagnosis (SDI) and the degree of invasion and survival in lung cancer. Three hundred seventy-eight patients with lung cancer were included. SDI was defined as the time calculated from the cytohistologic...
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| Veröffentlicht in: | Journal of clinical epidemiology 2003-09, Vol.56 (9), p.820-825 |
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| creator | Pita-Fernández, Salvador Montero-Martinez, Carmen Pértega-Diaz, Sonia Verea-Hernando, Hector |
| description | The aim of this study is to evaluate the relationship between the interval from first symptom to diagnosis (SDI) and the degree of invasion and survival in lung cancer.
Three hundred seventy-eight patients with lung cancer were included. SDI was defined as the time calculated from the cytohistologic confirmation of the diagnosis of cancer and the first symptoms noted by the patient and attributed to cancer by the physician. The degree of invasion was determined by TNM classification.
The median SDI was 2.1 months, and did not correlate with stage. Survival decreased progressively according to TNM classification. Adjusting for age, sex, SDI and TNM, survival was influenced by age (RR=1.02) and by staging [Stage (Ib) RR=1.3; stage (IIIa) RR=2.6; stage (IIIb) RR=4.06; stage (IV) RR=7.5]. SDI was not found to affect survival (RR=1.01; 95% CI: 0.94–1.08). In the small cell group, SDI also failed to modify survival.
The results of this study indicate that SDI has no effect on the stage or survival of patients with lung cancer. |
| doi_str_mv | 10.1016/S0895-4356(03)00166-5 |
| format | Article |
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Three hundred seventy-eight patients with lung cancer were included. SDI was defined as the time calculated from the cytohistologic confirmation of the diagnosis of cancer and the first symptoms noted by the patient and attributed to cancer by the physician. The degree of invasion was determined by TNM classification.
The median SDI was 2.1 months, and did not correlate with stage. Survival decreased progressively according to TNM classification. Adjusting for age, sex, SDI and TNM, survival was influenced by age (RR=1.02) and by staging [Stage (Ib) RR=1.3; stage (IIIa) RR=2.6; stage (IIIb) RR=4.06; stage (IV) RR=7.5]. SDI was not found to affect survival (RR=1.01; 95% CI: 0.94–1.08). In the small cell group, SDI also failed to modify survival.
The results of this study indicate that SDI has no effect on the stage or survival of patients with lung cancer.</description><identifier>ISSN: 0895-4356</identifier><identifier>EISSN: 1878-5921</identifier><identifier>DOI: 10.1016/S0895-4356(03)00166-5</identifier><identifier>PMID: 14505765</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Age Factors ; Aged ; Biological and medical sciences ; Delay ; Diagnosis ; Epidemiology ; Female ; Follow-Up Studies ; Humans ; Lung cancer ; Lung neoplasms ; Lung Neoplasms - mortality ; Lung Neoplasms - pathology ; Lung Neoplasms - therapy ; Male ; Medical sciences ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Staging ; Pneumology ; Prognosis ; Risk Factors ; Statistics, Nonparametric ; Survival ; Survival Rate ; Symptom duration ; Time Factors ; Tumors of the respiratory system and mediastinum</subject><ispartof>Journal of clinical epidemiology, 2003-09, Vol.56 (9), p.820-825</ispartof><rights>2003 Elsevier Inc.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-26ab7ab80e2714d25ad8aedbef9b1e946d69db12bd832ba468ab92f00ebaf3263</citedby><cites>FETCH-LOGICAL-c421t-26ab7ab80e2714d25ad8aedbef9b1e946d69db12bd832ba468ab92f00ebaf3263</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1033316330?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15200412$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14505765$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pita-Fernández, Salvador</creatorcontrib><creatorcontrib>Montero-Martinez, Carmen</creatorcontrib><creatorcontrib>Pértega-Diaz, Sonia</creatorcontrib><creatorcontrib>Verea-Hernando, Hector</creatorcontrib><title>Relationship between delayed diagnosis and the degree of invasion and survival in lung cancer</title><title>Journal of clinical epidemiology</title><addtitle>J Clin Epidemiol</addtitle><description>The aim of this study is to evaluate the relationship between the interval from first symptom to diagnosis (SDI) and the degree of invasion and survival in lung cancer.
Three hundred seventy-eight patients with lung cancer were included. SDI was defined as the time calculated from the cytohistologic confirmation of the diagnosis of cancer and the first symptoms noted by the patient and attributed to cancer by the physician. The degree of invasion was determined by TNM classification.
The median SDI was 2.1 months, and did not correlate with stage. Survival decreased progressively according to TNM classification. Adjusting for age, sex, SDI and TNM, survival was influenced by age (RR=1.02) and by staging [Stage (Ib) RR=1.3; stage (IIIa) RR=2.6; stage (IIIb) RR=4.06; stage (IV) RR=7.5]. SDI was not found to affect survival (RR=1.01; 95% CI: 0.94–1.08). In the small cell group, SDI also failed to modify survival.
The results of this study indicate that SDI has no effect on the stage or survival of patients with lung cancer.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Delay</subject><subject>Diagnosis</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Lung cancer</subject><subject>Lung neoplasms</subject><subject>Lung Neoplasms - mortality</subject><subject>Lung Neoplasms - pathology</subject><subject>Lung Neoplasms - therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Staging</subject><subject>Pneumology</subject><subject>Prognosis</subject><subject>Risk Factors</subject><subject>Statistics, Nonparametric</subject><subject>Survival</subject><subject>Survival Rate</subject><subject>Symptom duration</subject><subject>Time Factors</subject><subject>Tumors of the respiratory system and mediastinum</subject><issn>0895-4356</issn><issn>1878-5921</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkE1r3DAQhkVpaTZJf0KLoDS0Byf6sGTrVEroRyAQSNJjESNrvFHwyhvJ3pJ_X2V3aaCXngbeed5heAh5y9kpZ1yf3bDWqKqWSn9k8hMrka7UC7LgbdNWygj-kiz-IgfkMOf7AjWsUa_JAa8VU41WC_LrGgeYwhjzXVhTh9NvxEh9CR_RUx9gGcccMoXo6XSHZbNMiHTsaYgbyKW4XeU5bcIGhpLSYY5L2kHsMB2TVz0MGd_s5xH5-e3r7fmP6vLq-8X5l8uqqwWfKqHBNeBahqLhtRcKfAvoHfbGcTS19tp4x4XzrRQOat2CM6JnDB30Umh5RE52d9dpfJgxT3YVcofDABHHOdtGaWOMqgv4_h_wfpxTLL9ZzqSUXEvJCqV2VJfGnBP2dp3CCtJjgeyTfbu1b5_UWibt1r5Vpfduf312K_TPrb3uAnzYA5A7GPpULIX8zCnBWM1F4T7vOCzSNgGTzV3AYtSHhN1k_Rj-88of45uhxw</recordid><startdate>20030901</startdate><enddate>20030901</enddate><creator>Pita-Fernández, Salvador</creator><creator>Montero-Martinez, Carmen</creator><creator>Pértega-Diaz, Sonia</creator><creator>Verea-Hernando, Hector</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7RV</scope><scope>7T2</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20030901</creationdate><title>Relationship between delayed diagnosis and the degree of invasion and survival in lung cancer</title><author>Pita-Fernández, Salvador ; Montero-Martinez, Carmen ; Pértega-Diaz, Sonia ; Verea-Hernando, Hector</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-26ab7ab80e2714d25ad8aedbef9b1e946d69db12bd832ba468ab92f00ebaf3263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Delay</topic><topic>Diagnosis</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Lung cancer</topic><topic>Lung neoplasms</topic><topic>Lung Neoplasms - mortality</topic><topic>Lung Neoplasms - pathology</topic><topic>Lung Neoplasms - therapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Staging</topic><topic>Pneumology</topic><topic>Prognosis</topic><topic>Risk Factors</topic><topic>Statistics, Nonparametric</topic><topic>Survival</topic><topic>Survival Rate</topic><topic>Symptom duration</topic><topic>Time Factors</topic><topic>Tumors of the respiratory system and mediastinum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pita-Fernández, Salvador</creatorcontrib><creatorcontrib>Montero-Martinez, Carmen</creatorcontrib><creatorcontrib>Pértega-Diaz, Sonia</creatorcontrib><creatorcontrib>Verea-Hernando, Hector</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pita-Fernández, Salvador</au><au>Montero-Martinez, Carmen</au><au>Pértega-Diaz, Sonia</au><au>Verea-Hernando, Hector</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between delayed diagnosis and the degree of invasion and survival in lung cancer</atitle><jtitle>Journal of clinical epidemiology</jtitle><addtitle>J Clin Epidemiol</addtitle><date>2003-09-01</date><risdate>2003</risdate><volume>56</volume><issue>9</issue><spage>820</spage><epage>825</epage><pages>820-825</pages><issn>0895-4356</issn><eissn>1878-5921</eissn><abstract>The aim of this study is to evaluate the relationship between the interval from first symptom to diagnosis (SDI) and the degree of invasion and survival in lung cancer.
Three hundred seventy-eight patients with lung cancer were included. SDI was defined as the time calculated from the cytohistologic confirmation of the diagnosis of cancer and the first symptoms noted by the patient and attributed to cancer by the physician. The degree of invasion was determined by TNM classification.
The median SDI was 2.1 months, and did not correlate with stage. Survival decreased progressively according to TNM classification. Adjusting for age, sex, SDI and TNM, survival was influenced by age (RR=1.02) and by staging [Stage (Ib) RR=1.3; stage (IIIa) RR=2.6; stage (IIIb) RR=4.06; stage (IV) RR=7.5]. SDI was not found to affect survival (RR=1.01; 95% CI: 0.94–1.08). In the small cell group, SDI also failed to modify survival.
The results of this study indicate that SDI has no effect on the stage or survival of patients with lung cancer.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>14505765</pmid><doi>10.1016/S0895-4356(03)00166-5</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of clinical epidemiology, 2003-09, Vol.56 (9), p.820-825 |
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| subjects | Age Factors Aged Biological and medical sciences Delay Diagnosis Epidemiology Female Follow-Up Studies Humans Lung cancer Lung neoplasms Lung Neoplasms - mortality Lung Neoplasms - pathology Lung Neoplasms - therapy Male Medical sciences Middle Aged Neoplasm Invasiveness Neoplasm Staging Pneumology Prognosis Risk Factors Statistics, Nonparametric Survival Survival Rate Symptom duration Time Factors Tumors of the respiratory system and mediastinum |
| title | Relationship between delayed diagnosis and the degree of invasion and survival in lung cancer |
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