Epidemiological data on Werdnig-Hoffmann disease in Germany (West-Thüringen)
This study contains the largest body of epidemiological data on Werdnig-Hoffmann disease (acute infantile spinal muscular atrophy; ASMA) in West-Thüringen in Germany. The incidence of ASMA was calculated to be 1 in 10,202 live births. The prevalence was 1 in 595,362 of the general population (as of...
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| Veröffentlicht in: | Human genetics 1993-04, Vol.91 (3), p.295-297 |
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| container_title | Human genetics |
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| creator | THIEME, A MITULLA, B SCHULZE, F SPIEGLER, A. W. J |
| description | This study contains the largest body of epidemiological data on Werdnig-Hoffmann disease (acute infantile spinal muscular atrophy; ASMA) in West-Thüringen in Germany. The incidence of ASMA was calculated to be 1 in 10,202 live births. The prevalence was 1 in 595,362 of the general population (as of 31 December 1987). The study gives an unexpectedly high incidence rate confirming the suggestion that ASMA in Central and Eastern Europe might be more frequent than in Western Europe. However, we consider that this high incidence rate in West-Thüringen is a result of the almost complete ascertainment made possible because of the well-organised and centralised health system existing in Thüringen over the last few decades. |
| doi_str_mv | 10.1007/BF00218278 |
| format | Article |
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Prion diseases</subject><subject>epidemiology</subject><subject>Female</subject><subject>Germany - epidemiology</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>man</subject><subject>Medical sciences</subject><subject>Neurology</subject><subject>Prevalence</subject><subject>Sex Factors</subject><subject>Spinal Muscular Atrophies of Childhood - epidemiology</subject><subject>Spinal Muscular Atrophies of Childhood - genetics</subject><subject>Werdnig-Hoffmann disease</subject><issn>0340-6717</issn><issn>1432-1203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEURYMotVY37oVZiKgwmu9kllraKihuCl0OmXzUyEymJu3C_-bOP2bEUpfCgwfvHi6PA8ApgjcIQnF7P4UQI4mF3ANDRAkuEYZkHwwhobDkAolDcJTSG4SIVZgNwEBSISHiQ_A8WXljO9-3_dJr1RZGrVXRh2Jhowl-WT70znUqhML4ZFWyhQ_FzMZ8-iguFzaty_nr12f0YWnD1TE4cKpN9mS7R2A-nczHD-XTy-xxfPdUaszEuuT504pZw5pGVtagPA3XSDroqCCEOmqM5ToD0jWiEhpzjR1pDGXEYUlG4OK3dhX7903-oe580rZtVbD9JtWC8apiAv8LIs6RJJBl8PoX1LFPKVpXr6LvVPyoEax_HNd_jjN8tm3dNJ01O3QrNefn21ylrNRFFbRPO4wKKGglyTdvHYMn</recordid><startdate>199304</startdate><enddate>199304</enddate><creator>THIEME, A</creator><creator>MITULLA, B</creator><creator>SCHULZE, F</creator><creator>SPIEGLER, A. 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Prion diseases</topic><topic>epidemiology</topic><topic>Female</topic><topic>Germany - epidemiology</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>man</topic><topic>Medical sciences</topic><topic>Neurology</topic><topic>Prevalence</topic><topic>Sex Factors</topic><topic>Spinal Muscular Atrophies of Childhood - epidemiology</topic><topic>Spinal Muscular Atrophies of Childhood - genetics</topic><topic>Werdnig-Hoffmann disease</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>THIEME, A</creatorcontrib><creatorcontrib>MITULLA, B</creatorcontrib><creatorcontrib>SCHULZE, F</creatorcontrib><creatorcontrib>SPIEGLER, A. W. 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J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epidemiological data on Werdnig-Hoffmann disease in Germany (West-Thüringen)</atitle><jtitle>Human genetics</jtitle><addtitle>Hum Genet</addtitle><date>1993-04</date><risdate>1993</risdate><volume>91</volume><issue>3</issue><spage>295</spage><epage>297</epage><pages>295-297</pages><issn>0340-6717</issn><eissn>1432-1203</eissn><coden>HUGEDQ</coden><abstract>This study contains the largest body of epidemiological data on Werdnig-Hoffmann disease (acute infantile spinal muscular atrophy; ASMA) in West-Thüringen in Germany. The incidence of ASMA was calculated to be 1 in 10,202 live births. The prevalence was 1 in 595,362 of the general population (as of 31 December 1987). The study gives an unexpectedly high incidence rate confirming the suggestion that ASMA in Central and Eastern Europe might be more frequent than in Western Europe. 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| ispartof | Human genetics, 1993-04, Vol.91 (3), p.295-297 |
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| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases epidemiology Female Germany - epidemiology Humans Incidence Male man Medical sciences Neurology Prevalence Sex Factors Spinal Muscular Atrophies of Childhood - epidemiology Spinal Muscular Atrophies of Childhood - genetics Werdnig-Hoffmann disease |
| title | Epidemiological data on Werdnig-Hoffmann disease in Germany (West-Thüringen) |
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