Increased Soluble Fibrin in Plasma of Patients with Disseminated Intravascular Coagulation
Plasma levels of soluble fibrin (SF) were measured in 1184 patients with disseminated intravascular coagulation (DIC) according to Japanese Ministry of Health and Welfare (JMHW) criteria. The usefulness of SF for the diagnosis of DIC was compared with other hemostatic molecular markers. Most hemosta...
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| Veröffentlicht in: | Clinical and applied thrombosis/hemostasis 2003-07, Vol.9 (3), p.233-240 |
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| creator | Wada, Hideo Sase, Tomohiro Matsumoto, Takeshi Kushiya, Fumihiko Sakakura, Miho Mori, Yoshitaka Nishikawa, Masakatsu Ohnishi, Katsuya Nakatani, Kaname Gabazza, Esteban C. Shiku, Hiroshi Nobori, Tsutomu |
| description | Plasma levels of soluble fibrin (SF) were measured in 1184 patients with disseminated intravascular coagulation (DIC) according to Japanese Ministry of Health and Welfare (JMHW) criteria. The usefulness of SF for the diagnosis of DIC was compared with other hemostatic molecular markers. Most hemostatic markers were significantly increased in patients with DIC than in those without DIC. Plasma levels of fibrin and fibrinogen degradation products, thrombin-antihtrombin complex, plasmin-plasmin inhibitor complex, D-dimer, thrombomodulin, and SF levels were also significantly higher in those with pre-DIC than in those without DIC. In classification of overt DIC by International Society of Thrombosis and Haemostasis (ISTH) criteria, most hemostatic markers were significantly increased in patients with overt DIC than in those without overt DIC. Plasma levels of SF 'in patients with DIC were significantly higher than those in patients with pre-DIC, which were significantly higher than in those without DIC. Plasma levels of SF were also significantly higher in patients with overt DIC than in those with non-overt DIC. The correlation between plasma SF levels and DIC score according to JMHW criteria or ISTH criteria was good. Receiver operating characteristic analysis shows that SF was the best marker for the diagnosis of DIC or overt DIC. These findings suggest that plasma SF might be useful marker for the diagnosis of DIC or overt DIC. |
| doi_str_mv | 10.1177/107602960300900308 |
| format | Article |
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The usefulness of SF for the diagnosis of DIC was compared with other hemostatic molecular markers. Most hemostatic markers were significantly increased in patients with DIC than in those without DIC. Plasma levels of fibrin and fibrinogen degradation products, thrombin-antihtrombin complex, plasmin-plasmin inhibitor complex, D-dimer, thrombomodulin, and SF levels were also significantly higher in those with pre-DIC than in those without DIC. In classification of overt DIC by International Society of Thrombosis and Haemostasis (ISTH) criteria, most hemostatic markers were significantly increased in patients with overt DIC than in those without overt DIC. Plasma levels of SF 'in patients with DIC were significantly higher than those in patients with pre-DIC, which were significantly higher than in those without DIC. Plasma levels of SF were also significantly higher in patients with overt DIC than in those with non-overt DIC. The correlation between plasma SF levels and DIC score according to JMHW criteria or ISTH criteria was good. Receiver operating characteristic analysis shows that SF was the best marker for the diagnosis of DIC or overt DIC. These findings suggest that plasma SF might be useful marker for the diagnosis of DIC or overt DIC.</description><identifier>ISSN: 1076-0296</identifier><identifier>EISSN: 1938-2723</identifier><identifier>DOI: 10.1177/107602960300900308</identifier><identifier>PMID: 14507112</identifier><language>eng</language><publisher>Thousand Oaks, CA: SAGE Publications</publisher><subject>Biomarkers - blood ; Disseminated Intravascular Coagulation - blood ; Fibrin - metabolism ; Hematologic Neoplasms - blood ; Humans ; Infection - blood ; Plasma ; Platelet Count ; Reference Values ; Reproducibility of Results ; ROC Curve</subject><ispartof>Clinical and applied thrombosis/hemostasis, 2003-07, Vol.9 (3), p.233-240</ispartof><rights>Copyright SAGE PUBLICATIONS, INC. Jul 2003</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-ae0eb648ec880d02e4d6e73c8d8e62a9a4c787bf771b4c917b91ee7224f666753</citedby><cites>FETCH-LOGICAL-c411t-ae0eb648ec880d02e4d6e73c8d8e62a9a4c787bf771b4c917b91ee7224f666753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/107602960300900308$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/107602960300900308$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21946,27832,27903,27904,44924,45312</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.1177/107602960300900308?utm_source=summon&utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14507112$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wada, Hideo</creatorcontrib><creatorcontrib>Sase, Tomohiro</creatorcontrib><creatorcontrib>Matsumoto, Takeshi</creatorcontrib><creatorcontrib>Kushiya, Fumihiko</creatorcontrib><creatorcontrib>Sakakura, Miho</creatorcontrib><creatorcontrib>Mori, Yoshitaka</creatorcontrib><creatorcontrib>Nishikawa, Masakatsu</creatorcontrib><creatorcontrib>Ohnishi, Katsuya</creatorcontrib><creatorcontrib>Nakatani, Kaname</creatorcontrib><creatorcontrib>Gabazza, Esteban C.</creatorcontrib><creatorcontrib>Shiku, Hiroshi</creatorcontrib><creatorcontrib>Nobori, Tsutomu</creatorcontrib><title>Increased Soluble Fibrin in Plasma of Patients with Disseminated Intravascular Coagulation</title><title>Clinical and applied thrombosis/hemostasis</title><addtitle>Clin Appl Thromb Hemost</addtitle><description>Plasma levels of soluble fibrin (SF) were measured in 1184 patients with disseminated intravascular coagulation (DIC) according to Japanese Ministry of Health and Welfare (JMHW) criteria. The usefulness of SF for the diagnosis of DIC was compared with other hemostatic molecular markers. Most hemostatic markers were significantly increased in patients with DIC than in those without DIC. Plasma levels of fibrin and fibrinogen degradation products, thrombin-antihtrombin complex, plasmin-plasmin inhibitor complex, D-dimer, thrombomodulin, and SF levels were also significantly higher in those with pre-DIC than in those without DIC. In classification of overt DIC by International Society of Thrombosis and Haemostasis (ISTH) criteria, most hemostatic markers were significantly increased in patients with overt DIC than in those without overt DIC. Plasma levels of SF 'in patients with DIC were significantly higher than those in patients with pre-DIC, which were significantly higher than in those without DIC. Plasma levels of SF were also significantly higher in patients with overt DIC than in those with non-overt DIC. The correlation between plasma SF levels and DIC score according to JMHW criteria or ISTH criteria was good. Receiver operating characteristic analysis shows that SF was the best marker for the diagnosis of DIC or overt DIC. These findings suggest that plasma SF might be useful marker for the diagnosis of DIC or overt DIC.</description><subject>Biomarkers - blood</subject><subject>Disseminated Intravascular Coagulation - blood</subject><subject>Fibrin - metabolism</subject><subject>Hematologic Neoplasms - blood</subject><subject>Humans</subject><subject>Infection - blood</subject><subject>Plasma</subject><subject>Platelet Count</subject><subject>Reference Values</subject><subject>Reproducibility of Results</subject><subject>ROC Curve</subject><issn>1076-0296</issn><issn>1938-2723</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp9kMtKA0EQRRtRTIz-gAsZENyN6Vf6sZRoNCAYUDduhp6emthhHrF7RvHv7ZBAQEEoqmpx7q3iInRO8DUhUo4JlgJTLTDDWOPY1QEaEs1USiVlh3GPQLohBugkhBXGRAstjtGA8AmWhNAheps31oMJUCTPbdXnFSQzl3vXJLEWlQm1SdoyWZjOQdOF5Mt178mtCwFq15guyuZN582nCbavjE-mrVnGpXNtc4qOSlMFONvNEXqd3b1MH9LHp_v59OYxtZyQLjWAIRdcgVUKF5gCLwRIZlWhQFCjDbdSybyUkuTcaiJzTQAkpbwUQsgJG6Grre_atx89hC6rXbBQVaaBtg-ZnAitmGYRvPwFrtreN_G3jDLOKWZCqUjRLWV9G4KHMlt7Vxv_nRGcbXLP_uYeRRc76z6vodhLdkFHYLwFglnC_u4_lj_YgIoy</recordid><startdate>20030701</startdate><enddate>20030701</enddate><creator>Wada, Hideo</creator><creator>Sase, Tomohiro</creator><creator>Matsumoto, Takeshi</creator><creator>Kushiya, Fumihiko</creator><creator>Sakakura, Miho</creator><creator>Mori, Yoshitaka</creator><creator>Nishikawa, Masakatsu</creator><creator>Ohnishi, Katsuya</creator><creator>Nakatani, Kaname</creator><creator>Gabazza, Esteban C.</creator><creator>Shiku, Hiroshi</creator><creator>Nobori, Tsutomu</creator><general>SAGE Publications</general><general>SAGE PUBLICATIONS, INC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20030701</creationdate><title>Increased Soluble Fibrin in Plasma of Patients with Disseminated Intravascular Coagulation</title><author>Wada, Hideo ; Sase, Tomohiro ; Matsumoto, Takeshi ; Kushiya, Fumihiko ; Sakakura, Miho ; Mori, Yoshitaka ; Nishikawa, Masakatsu ; Ohnishi, Katsuya ; Nakatani, Kaname ; Gabazza, Esteban C. ; Shiku, Hiroshi ; Nobori, Tsutomu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-ae0eb648ec880d02e4d6e73c8d8e62a9a4c787bf771b4c917b91ee7224f666753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Biomarkers - blood</topic><topic>Disseminated Intravascular Coagulation - blood</topic><topic>Fibrin - metabolism</topic><topic>Hematologic Neoplasms - blood</topic><topic>Humans</topic><topic>Infection - blood</topic><topic>Plasma</topic><topic>Platelet Count</topic><topic>Reference Values</topic><topic>Reproducibility of Results</topic><topic>ROC Curve</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wada, Hideo</creatorcontrib><creatorcontrib>Sase, Tomohiro</creatorcontrib><creatorcontrib>Matsumoto, Takeshi</creatorcontrib><creatorcontrib>Kushiya, Fumihiko</creatorcontrib><creatorcontrib>Sakakura, Miho</creatorcontrib><creatorcontrib>Mori, Yoshitaka</creatorcontrib><creatorcontrib>Nishikawa, Masakatsu</creatorcontrib><creatorcontrib>Ohnishi, Katsuya</creatorcontrib><creatorcontrib>Nakatani, Kaname</creatorcontrib><creatorcontrib>Gabazza, Esteban C.</creatorcontrib><creatorcontrib>Shiku, Hiroshi</creatorcontrib><creatorcontrib>Nobori, Tsutomu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and applied thrombosis/hemostasis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Wada, Hideo</au><au>Sase, Tomohiro</au><au>Matsumoto, Takeshi</au><au>Kushiya, Fumihiko</au><au>Sakakura, Miho</au><au>Mori, Yoshitaka</au><au>Nishikawa, Masakatsu</au><au>Ohnishi, Katsuya</au><au>Nakatani, Kaname</au><au>Gabazza, Esteban C.</au><au>Shiku, Hiroshi</au><au>Nobori, Tsutomu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased Soluble Fibrin in Plasma of Patients with Disseminated Intravascular Coagulation</atitle><jtitle>Clinical and applied thrombosis/hemostasis</jtitle><addtitle>Clin Appl Thromb Hemost</addtitle><date>2003-07-01</date><risdate>2003</risdate><volume>9</volume><issue>3</issue><spage>233</spage><epage>240</epage><pages>233-240</pages><issn>1076-0296</issn><eissn>1938-2723</eissn><abstract>Plasma levels of soluble fibrin (SF) were measured in 1184 patients with disseminated intravascular coagulation (DIC) according to Japanese Ministry of Health and Welfare (JMHW) criteria. The usefulness of SF for the diagnosis of DIC was compared with other hemostatic molecular markers. Most hemostatic markers were significantly increased in patients with DIC than in those without DIC. Plasma levels of fibrin and fibrinogen degradation products, thrombin-antihtrombin complex, plasmin-plasmin inhibitor complex, D-dimer, thrombomodulin, and SF levels were also significantly higher in those with pre-DIC than in those without DIC. In classification of overt DIC by International Society of Thrombosis and Haemostasis (ISTH) criteria, most hemostatic markers were significantly increased in patients with overt DIC than in those without overt DIC. Plasma levels of SF 'in patients with DIC were significantly higher than those in patients with pre-DIC, which were significantly higher than in those without DIC. Plasma levels of SF were also significantly higher in patients with overt DIC than in those with non-overt DIC. The correlation between plasma SF levels and DIC score according to JMHW criteria or ISTH criteria was good. Receiver operating characteristic analysis shows that SF was the best marker for the diagnosis of DIC or overt DIC. These findings suggest that plasma SF might be useful marker for the diagnosis of DIC or overt DIC.</abstract><cop>Thousand Oaks, CA</cop><pub>SAGE Publications</pub><pmid>14507112</pmid><doi>10.1177/107602960300900308</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Clinical and applied thrombosis/hemostasis, 2003-07, Vol.9 (3), p.233-240 |
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| language | eng |
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| source | Sage Journals GOLD Open Access 2024 |
| subjects | Biomarkers - blood Disseminated Intravascular Coagulation - blood Fibrin - metabolism Hematologic Neoplasms - blood Humans Infection - blood Plasma Platelet Count Reference Values Reproducibility of Results ROC Curve |
| title | Increased Soluble Fibrin in Plasma of Patients with Disseminated Intravascular Coagulation |
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