Use of colchicine to inhibit wound contraction

Rats and rabbits with full-thickness skin excisions were treated topically and systemically with colchicine. Wounds which had been covered by an occlusive plastic dressing and treated topically showed an inhibition of wound contraction, but only at the expense of local toxicity. Systemic colchicine...

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Veröffentlicht in:	The American journal of surgery 1981-06, Vol.141 (6), p.712-717
Hauptverfasser:	Rudolph, Ross, Hum, Irwin, Woodward, Marilyn
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Animals Colchicine - therapeutic use Fibroblasts - ultrastructure Male Rabbits Rats Skin - injuries Skin - pathology Skin - ultrastructure Wound Healing - drug effects Wounds and Injuries - drug therapy Wounds and Injuries - pathology
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