12(S)-HETE promotes tumor-cell adhesion by increasing surface expression of alpha V beta 3 integrins on endothelial cells

The present work was undertaken to investigate the regulatory role of 12(S)-HETE, a lipoxygenase metabolite of arachidonic acid, in the surface expression of alpha v beta 3 integrin receptors in endothelial cells (rat aortic endothelial cells, or RAEC). Several monoclonal and polyclonal antibodies l...

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Veröffentlicht in:	International journal of cancer 1993-04, Vol.54 (1), p.102-111
Hauptverfasser:	Tang, D G, Grossi, I M, Chen, Y Q, Diglio, C A, Honn, K V
Format:	Artikel
Sprache:	eng
Schlagworte:	12-Hydroxy-5,8,10,14-eicosatetraenoic Acid Actin Cytoskeleton - metabolism Animals Base Sequence Blotting, Western Carcinoma 256, Walker - pathology Cell Adhesion - drug effects Cell Compartmentation Cell Membrane - metabolism Endothelium, Vascular - cytology Endothelium, Vascular - metabolism Gene Expression Hydroxyeicosatetraenoic Acids - pharmacology In Vitro Techniques Integrins - genetics Integrins - metabolism Molecular Sequence Data Oligodeoxyribonucleotides - chemistry Rats RNA, Messenger - genetics
Online-Zugang:	Volltext
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