SYNTHESIS AND ANTIFUNGAL SELECTIVITY OF NEW DERIVATIVES OF AMPHOTERICIN B MODIFIED AT THE C-13 POSITION

The syntheses of the first amphotericin B derivatives to be modified solely at the C-13 hemiketal position are described. Selective functionalisation at this position is facilitated by use of the allyl ester as a C-16 carboxylate protecting group on the amphotericin B nucleus. In in vitro tests all...

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Veröffentlicht in:	Journal of antibiotics 1993/03/25, Vol.46(3), pp.486-493
Hauptverfasser:	TAYLOR, ANDREW W., COSTELLO, BENJAMIN J., HUNTER, PAMELA A., MACLACHLAN, WILLIAM S., SHANKS, COLIN T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphotericin B - analogs & derivatives Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antifungal Agents - chemical synthesis Antifungal Agents - chemistry Antifungal Agents - pharmacology Biological and medical sciences Erythrocytes - drug effects Horses Medical sciences Microbial Sensitivity Tests Pharmacology. Drug treatments Structure-Activity Relationship
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