The Rat SSTR2 Somatostatin Receptor Subtype Is Coupled to Inhibition of Cyclic AMP Accumulation

The rat somatostatin receptor SSTR2 subtype has been cloned and expressed in Chinese Hamster Ovary (CHO) cells. Four different radioligands were used to determine the pharmacological properties of this somatostatin receptor subtype. [125ITyr11]S-14, [125ITyr25]S-28, and cyclo (D-Trp-Lys-Abu-Phe-MeAl...

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Veröffentlicht in:	Biochemical and biophysical research communications 1993-03, Vol.191 (3), p.968-976
Hauptverfasser:	Strnad, J., Eppler, C.M., Corbett, M., Hadcock, J.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Biological and medical sciences Cell receptors Cell structures and functions CHO Cells Cloning, Molecular Cricetinae Cyclic AMP - metabolism DNA - genetics Fundamental and applied biological sciences. Psychology Guanosine 5'-O-(3-Thiotriphosphate) - metabolism Hormone receptors. Growth factor receptors. Cytokine receptors. Prostaglandin receptors Kinetics Molecular and cellular biology Molecular Sequence Data Oligodeoxyribonucleotides - chemistry Polymerase Chain Reaction Rats Receptors, Somatostatin - physiology Somatostatin - metabolism Transfection
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