Vasopressinase-Altered Vasopressin Elevates Arterial Pressure in Anesthetized Rats
ABSTRACT Transient diabetes insipidus of pregnancy (TDIP) is associated with elevated activity of vasopressinase, a plasma enzyme that opens the vasopressin (AVP) ring to produce a linear peptide that we have named vasopressinase-altered vasopressin (VAV). VAV may play a role in the pathogenesis of...
Gespeichert in:
| Veröffentlicht in: | American journal of perinatology 1993-03, Vol.10 (2), p.160-163 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 163 |
|---|---|
| container_issue | 2 |
| container_start_page | 160 |
| container_title | American journal of perinatology |
| container_volume | 10 |
| creator | Krege, John H. Faber, James E. Klapper, David G. Katz, Vern L. Colindres, Romulo E. |
| description | ABSTRACT
Transient diabetes insipidus of pregnancy (TDIP) is associated with elevated activity of vasopressinase, a plasma enzyme that opens the vasopressin (AVP) ring to produce a linear peptide that we have named vasopressinase-altered vasopressin (VAV). VAV may play a role in the pathogenesis of the arterial hypertension associated with TDIP. We sought to determine if VAV elevates arterial pressure, the potency of VAV relative to that of AVP, and whether the peptide binds to the vascular AVP receptor. AVP was incubated with vasopressinase and VAV was separated from residual AVP by high-pressure liquid chromatography. Intravenous bolus administration of VAV or AVP to ganglionic blocked rats produced dose-dependent increases in arterial pressure, with VAV demonstrating approximately 6000-fold lower potency than AVP. Vasopressin receptor blockade abolished the response to both AVP and VAV. These results suggest that high levels of VAV may contribute to the hypertension seen in TDIP. |
| doi_str_mv | 10.1055/s-2007-994651 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_75692066</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>75692066</sourcerecordid><originalsourceid>FETCH-LOGICAL-c325t-fc4a3403671ef64b71789ada9e2f7ce79872e81b41d3f5910a2f5b37f3b585293</originalsourceid><addsrcrecordid>eNp1kEtLw0AURgdRaq0uXQpZuXJ0HpnXspT6gIJS1O0wSW5oSh51JhH01zslRdy4ujDnzMe9H0KXlNxSIsRdwIwQhY1JpaBHaEqJ0VgrLY7RlCguMJWcnqKzELaEUKaJnqCJTpVMNZui9bsL3c5DCFXrAuB53YOHIvnznCxr-HQ9hGTuI6xcnbzsyeAhiXTeQug30Fff8dva9eEcnZSuDnBxmDP0dr98XTzi1fPD02K-wjlnosdlnjqeEi4VhVKmmaJKG1c4A6xUOSijFQNNs5QWvBSGEsdKkXFV8kxowQyfoesxd-e7jyEuYZsq5FDXroVuCFYJaRiRMop4FHPfheChtDtfNc5_WUrsvkMb7L5DO3YY_atD8JA1UPzah9Iivxl5v6mgAbvtBt_GS_-J-wHqU3q8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>75692066</pqid></control><display><type>article</type><title>Vasopressinase-Altered Vasopressin Elevates Arterial Pressure in Anesthetized Rats</title><source>MEDLINE</source><source>Thieme Connect Journals</source><creator>Krege, John H. ; Faber, James E. ; Klapper, David G. ; Katz, Vern L. ; Colindres, Romulo E.</creator><creatorcontrib>Krege, John H. ; Faber, James E. ; Klapper, David G. ; Katz, Vern L. ; Colindres, Romulo E.</creatorcontrib><description>ABSTRACT
Transient diabetes insipidus of pregnancy (TDIP) is associated with elevated activity of vasopressinase, a plasma enzyme that opens the vasopressin (AVP) ring to produce a linear peptide that we have named vasopressinase-altered vasopressin (VAV). VAV may play a role in the pathogenesis of the arterial hypertension associated with TDIP. We sought to determine if VAV elevates arterial pressure, the potency of VAV relative to that of AVP, and whether the peptide binds to the vascular AVP receptor. AVP was incubated with vasopressinase and VAV was separated from residual AVP by high-pressure liquid chromatography. Intravenous bolus administration of VAV or AVP to ganglionic blocked rats produced dose-dependent increases in arterial pressure, with VAV demonstrating approximately 6000-fold lower potency than AVP. Vasopressin receptor blockade abolished the response to both AVP and VAV. These results suggest that high levels of VAV may contribute to the hypertension seen in TDIP.</description><identifier>ISSN: 0735-1631</identifier><identifier>EISSN: 1098-8785</identifier><identifier>DOI: 10.1055/s-2007-994651</identifier><identifier>PMID: 8476482</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Arginine Vasopressin - metabolism ; Arginine Vasopressin - pharmacology ; Blood Pressure - drug effects ; Dose-Response Relationship, Drug ; Hypertension - metabolism ; Hypertension - physiopathology ; Male ; ORIGINAL ARTICLE ; Rats ; Rats, Sprague-Dawley ; Vasopressins</subject><ispartof>American journal of perinatology, 1993-03, Vol.10 (2), p.160-163</ispartof><rights>1993 by Thieme Medical Publishers, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c325t-fc4a3403671ef64b71789ada9e2f7ce79872e81b41d3f5910a2f5b37f3b585293</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2007-994651.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1055/s-2007-994651$$EHTML$$P50$$Gthieme$$H</linktohtml><link.rule.ids>314,776,780,3004,3005,27901,27902,54534,54535</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8476482$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Krege, John H.</creatorcontrib><creatorcontrib>Faber, James E.</creatorcontrib><creatorcontrib>Klapper, David G.</creatorcontrib><creatorcontrib>Katz, Vern L.</creatorcontrib><creatorcontrib>Colindres, Romulo E.</creatorcontrib><title>Vasopressinase-Altered Vasopressin Elevates Arterial Pressure in Anesthetized Rats</title><title>American journal of perinatology</title><addtitle>Amer J Perinatol</addtitle><description>ABSTRACT
Transient diabetes insipidus of pregnancy (TDIP) is associated with elevated activity of vasopressinase, a plasma enzyme that opens the vasopressin (AVP) ring to produce a linear peptide that we have named vasopressinase-altered vasopressin (VAV). VAV may play a role in the pathogenesis of the arterial hypertension associated with TDIP. We sought to determine if VAV elevates arterial pressure, the potency of VAV relative to that of AVP, and whether the peptide binds to the vascular AVP receptor. AVP was incubated with vasopressinase and VAV was separated from residual AVP by high-pressure liquid chromatography. Intravenous bolus administration of VAV or AVP to ganglionic blocked rats produced dose-dependent increases in arterial pressure, with VAV demonstrating approximately 6000-fold lower potency than AVP. Vasopressin receptor blockade abolished the response to both AVP and VAV. These results suggest that high levels of VAV may contribute to the hypertension seen in TDIP.</description><subject>Animals</subject><subject>Arginine Vasopressin - metabolism</subject><subject>Arginine Vasopressin - pharmacology</subject><subject>Blood Pressure - drug effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>Hypertension - metabolism</subject><subject>Hypertension - physiopathology</subject><subject>Male</subject><subject>ORIGINAL ARTICLE</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Vasopressins</subject><issn>0735-1631</issn><issn>1098-8785</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtLw0AURgdRaq0uXQpZuXJ0HpnXspT6gIJS1O0wSW5oSh51JhH01zslRdy4ujDnzMe9H0KXlNxSIsRdwIwQhY1JpaBHaEqJ0VgrLY7RlCguMJWcnqKzELaEUKaJnqCJTpVMNZui9bsL3c5DCFXrAuB53YOHIvnznCxr-HQ9hGTuI6xcnbzsyeAhiXTeQug30Fff8dva9eEcnZSuDnBxmDP0dr98XTzi1fPD02K-wjlnosdlnjqeEi4VhVKmmaJKG1c4A6xUOSijFQNNs5QWvBSGEsdKkXFV8kxowQyfoesxd-e7jyEuYZsq5FDXroVuCFYJaRiRMop4FHPfheChtDtfNc5_WUrsvkMb7L5DO3YY_atD8JA1UPzah9Iivxl5v6mgAbvtBt_GS_-J-wHqU3q8</recordid><startdate>19930301</startdate><enddate>19930301</enddate><creator>Krege, John H.</creator><creator>Faber, James E.</creator><creator>Klapper, David G.</creator><creator>Katz, Vern L.</creator><creator>Colindres, Romulo E.</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19930301</creationdate><title>Vasopressinase-Altered Vasopressin Elevates Arterial Pressure in Anesthetized Rats</title><author>Krege, John H. ; Faber, James E. ; Klapper, David G. ; Katz, Vern L. ; Colindres, Romulo E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c325t-fc4a3403671ef64b71789ada9e2f7ce79872e81b41d3f5910a2f5b37f3b585293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Arginine Vasopressin - metabolism</topic><topic>Arginine Vasopressin - pharmacology</topic><topic>Blood Pressure - drug effects</topic><topic>Dose-Response Relationship, Drug</topic><topic>Hypertension - metabolism</topic><topic>Hypertension - physiopathology</topic><topic>Male</topic><topic>ORIGINAL ARTICLE</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Vasopressins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Krege, John H.</creatorcontrib><creatorcontrib>Faber, James E.</creatorcontrib><creatorcontrib>Klapper, David G.</creatorcontrib><creatorcontrib>Katz, Vern L.</creatorcontrib><creatorcontrib>Colindres, Romulo E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of perinatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Krege, John H.</au><au>Faber, James E.</au><au>Klapper, David G.</au><au>Katz, Vern L.</au><au>Colindres, Romulo E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vasopressinase-Altered Vasopressin Elevates Arterial Pressure in Anesthetized Rats</atitle><jtitle>American journal of perinatology</jtitle><addtitle>Amer J Perinatol</addtitle><date>1993-03-01</date><risdate>1993</risdate><volume>10</volume><issue>2</issue><spage>160</spage><epage>163</epage><pages>160-163</pages><issn>0735-1631</issn><eissn>1098-8785</eissn><abstract>ABSTRACT
Transient diabetes insipidus of pregnancy (TDIP) is associated with elevated activity of vasopressinase, a plasma enzyme that opens the vasopressin (AVP) ring to produce a linear peptide that we have named vasopressinase-altered vasopressin (VAV). VAV may play a role in the pathogenesis of the arterial hypertension associated with TDIP. We sought to determine if VAV elevates arterial pressure, the potency of VAV relative to that of AVP, and whether the peptide binds to the vascular AVP receptor. AVP was incubated with vasopressinase and VAV was separated from residual AVP by high-pressure liquid chromatography. Intravenous bolus administration of VAV or AVP to ganglionic blocked rats produced dose-dependent increases in arterial pressure, with VAV demonstrating approximately 6000-fold lower potency than AVP. Vasopressin receptor blockade abolished the response to both AVP and VAV. These results suggest that high levels of VAV may contribute to the hypertension seen in TDIP.</abstract><cop>United States</cop><pmid>8476482</pmid><doi>10.1055/s-2007-994651</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0735-1631 |
| ispartof | American journal of perinatology, 1993-03, Vol.10 (2), p.160-163 |
| issn | 0735-1631 1098-8785 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75692066 |
| source | MEDLINE; Thieme Connect Journals |
| subjects | Animals Arginine Vasopressin - metabolism Arginine Vasopressin - pharmacology Blood Pressure - drug effects Dose-Response Relationship, Drug Hypertension - metabolism Hypertension - physiopathology Male ORIGINAL ARTICLE Rats Rats, Sprague-Dawley Vasopressins |
| title | Vasopressinase-Altered Vasopressin Elevates Arterial Pressure in Anesthetized Rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T08%3A43%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Vasopressinase-Altered%20Vasopressin%20Elevates%20Arterial%20Pressure%20in%20Anesthetized%20Rats&rft.jtitle=American%20journal%20of%20perinatology&rft.au=Krege,%20John%20H.&rft.date=1993-03-01&rft.volume=10&rft.issue=2&rft.spage=160&rft.epage=163&rft.pages=160-163&rft.issn=0735-1631&rft.eissn=1098-8785&rft_id=info:doi/10.1055/s-2007-994651&rft_dat=%3Cproquest_cross%3E75692066%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=75692066&rft_id=info:pmid/8476482&rfr_iscdi=true |