Diethyldithiocarbamate inhibits induction of macrophage NO synthase

We investigated whether sodium diethyldithiocarbamate (DETC), an inhibitor of the nuclear transcription factor kappa B (NFkappaB), modulates induction of NO synthase (NOS) in murine bone marrow-derived macrophages. A short exposure (between 1 and 16 h) of L929-cell medium-preconditioned macrophages...

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Veröffentlicht in:	FEBS letters 1993-04, Vol.321 (2), p.215-218
Hauptverfasser:	Mülsch, Alexander, Schray-Utz, Beate, Mordvintcev, Peter I., Hauschildt, Sunna, Busse, Rudi
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Oxidoreductases - biosynthesis Amino Acid Oxidoreductases - genetics Animals Biological and medical sciences Blotting, Northern Bone Marrow - drug effects Bone Marrow - enzymology Bone Marrow Cells Bone marrow-derived macrophage Cells, Cultured Culture Media, Conditioned Diethyldithiocarbamate Ditiocarb - pharmacology DNA Probes Enzyme Induction - drug effects Fundamental and applied biological sciences. Psychology L Cells (Cell Line) Macrophages - cytology Macrophages - drug effects Macrophages - enzymology Mice Mice, Inbred BALB C Molecular and cellular biology Molecular genetics NF-kappa B - antagonists & inhibitors NFkappaB Nitric Oxide Synthase Nitrites - metabolism NO synthase RNA, Messenger - analysis RNA, Messenger - metabolism Transcription Transcription. Transcription factor. Splicing. Rna processing
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