Intravenous infusion of prostacyclin sodium in man: clinical effects and influence on platelet adenosine diphosphate sensitivity and adenosine 3':5'-cyclic monophosphate levels

Clinical tolerance, inhibition of platelet aggregation and intracellular platelet adenosine 3':5'-cyclic monophosphate (cyclic AMP) levels were evaluated in normal volunteers given i.v. infusions of prostacyclin sodium at rates up to 15 ng/kg/min. Short-term infusions (30 and 60 minutes) w...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 1981-07, Vol.64 (1), p.4-12
Hauptverfasser:	Data, J L, Molony, B A, Meinzinger, M M, Gorman, R R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate Adult Bleeding Time Blood Glucose Blood Platelets - analysis Blood Pressure - drug effects Cyclic AMP Electrocardiography Epoprostenol - administration & dosage Humans Infusions, Parenteral Male Platelet Aggregation - drug effects Prostaglandins - administration & dosage
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