Prevalence and incidence of left ventricular dysfunction in patients with human immunodeficiency virus infection
The prevalence and incidence of left ventricular (LV) dysfunction was examined in patients infected with the human immunodeficiency virus (HIV). Sixty-nine randomly selected patients diagnosed with HIV infection who were followed in HIV clinics were prospectively evaluated by 2-dimensional echocardi...
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| Veröffentlicht in: | The American journal of cardiology 1993-04, Vol.71 (11), p.955-958 |
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| container_title | The American journal of cardiology |
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| creator | Herskowitz, Ahvie Vlahov, David Willoughby, Sharon Chaisson, Richard E. Schulman, Steven P. Neumann, David A. Baughman, Kenneth L. |
| description | The prevalence and incidence of left ventricular (LV) dysfunction was examined in patients infected with the human immunodeficiency virus (HIV). Sixty-nine randomly selected patients diagnosed with HIV infection who were followed in HIV clinics were prospectively evaluated by 2-dimensional echocardiography. Mean follow-up duration was 11 months. Additionally, 39 consecutive HIV-infected patients referred to the Cardiomyopathy Service and found to have LV dysfunction by 2-dimensional echocardiography were also studied. Of the 39 referred patients, 34 (87%) were referred for recent onset, unexplained, congestive heart failure. During this time, the HIV clinic population comprised 1,819 alive and actively followed patients; the 39 cardiomyopathy referrals therefore constituted a crude rate of 2.1% for this population. Of the 69 prospectively studied patients without clinical heart disease, a 14.5% prevalence of global LV hypokinesia and an incidence of 18%/patient-year were found. During a maximal 18-month follow-up period, 4 prospective patients (5.8%) developed symptoms of congestive heart failure. A greater proportion of prospective and referred patients with LV dysfunction had CD4 counts |
| doi_str_mv | 10.1016/0002-9149(93)90913-W |
| format | Article |
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3 (62 and 79%, respectively) than did that of those without LV dysfunction (35%). In conclusion, the high rate of unexpected LV dysfunction in this HIV-infected population suggests that early cardiac contractile abnormalities may involve a significant number of patients, most of whom have low CD4 counts. A subgroup of these patients appears to progress to symptomatic congestive heart failure.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/0002-9149(93)90913-W</identifier><identifier>PMID: 8465788</identifier><identifier>CODEN: AJCDAG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; AIDS/HIV ; Biological and medical sciences ; Cardiomyopathy, Dilated - diagnostic imaging ; Cardiomyopathy, Dilated - epidemiology ; Cardiomyopathy, Dilated - physiopathology ; Cardiovascular disease ; Echocardiography ; Female ; HIV ; HIV Infections - complications ; HIV Infections - physiopathology ; Human immunodeficiency virus ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Incidence ; Male ; Medical research ; Medical sciences ; Prevalence ; Prospective Studies ; Ventricular Function, Left</subject><ispartof>The American journal of cardiology, 1993-04, Vol.71 (11), p.955-958</ispartof><rights>1993</rights><rights>1993 INIST-CNRS</rights><rights>Copyright Elsevier Sequoia S.A. Apr 15, 1993</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-ae53a977978df09153185116c5d3fc4613b081928145fd29756a432e2ed945573</citedby><cites>FETCH-LOGICAL-c444t-ae53a977978df09153185116c5d3fc4613b081928145fd29756a432e2ed945573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0002-9149(93)90913-W$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4698313$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8465788$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Herskowitz, Ahvie</creatorcontrib><creatorcontrib>Vlahov, David</creatorcontrib><creatorcontrib>Willoughby, Sharon</creatorcontrib><creatorcontrib>Chaisson, Richard E.</creatorcontrib><creatorcontrib>Schulman, Steven P.</creatorcontrib><creatorcontrib>Neumann, David A.</creatorcontrib><creatorcontrib>Baughman, Kenneth L.</creatorcontrib><title>Prevalence and incidence of left ventricular dysfunction in patients with human immunodeficiency virus infection</title><title>The American journal of cardiology</title><addtitle>Am J Cardiol</addtitle><description>The prevalence and incidence of left ventricular (LV) dysfunction was examined in patients infected with the human immunodeficiency virus (HIV). Sixty-nine randomly selected patients diagnosed with HIV infection who were followed in HIV clinics were prospectively evaluated by 2-dimensional echocardiography. Mean follow-up duration was 11 months. Additionally, 39 consecutive HIV-infected patients referred to the Cardiomyopathy Service and found to have LV dysfunction by 2-dimensional echocardiography were also studied. Of the 39 referred patients, 34 (87%) were referred for recent onset, unexplained, congestive heart failure. During this time, the HIV clinic population comprised 1,819 alive and actively followed patients; the 39 cardiomyopathy referrals therefore constituted a crude rate of 2.1% for this population. Of the 69 prospectively studied patients without clinical heart disease, a 14.5% prevalence of global LV hypokinesia and an incidence of 18%/patient-year were found. During a maximal 18-month follow-up period, 4 prospective patients (5.8%) developed symptoms of congestive heart failure. A greater proportion of prospective and referred patients with LV dysfunction had CD4 counts <100/mm
3 (62 and 79%, respectively) than did that of those without LV dysfunction (35%). In conclusion, the high rate of unexpected LV dysfunction in this HIV-infected population suggests that early cardiac contractile abnormalities may involve a significant number of patients, most of whom have low CD4 counts. A subgroup of these patients appears to progress to symptomatic congestive heart failure.</description><subject>Adult</subject><subject>AIDS/HIV</subject><subject>Biological and medical sciences</subject><subject>Cardiomyopathy, Dilated - diagnostic imaging</subject><subject>Cardiomyopathy, Dilated - epidemiology</subject><subject>Cardiomyopathy, Dilated - physiopathology</subject><subject>Cardiovascular disease</subject><subject>Echocardiography</subject><subject>Female</subject><subject>HIV</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - physiopathology</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Incidence</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Prevalence</subject><subject>Prospective Studies</subject><subject>Ventricular Function, Left</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuLFTEQhYMo453Rf6DQiIguWlOdRyebARnGBwzoQpllyCQVJkM_rknnyv335j64Cxe6CpXznaKqDiEvgL4HCvIDpbRrNXD9VrN3mmpg7e0jsgLV6xZq9ZisTshTcp7zQy0BhDwjZ4pL0Su1IuvvCTd2wMlhYyffxMlFv6_m0AwYlmaD05KiK4NNjd_mUCa3xHmqZLO2S6xqbn7H5b65L6Ot3-NYptljiK5qbttsYiq50gH3vmfkSbBDxufH94L8_HT94-pLe_Pt89erjzet45wvrUXBrO573Ssf6m6CgRIA0gnPguMS2B1VoDsFXATf6V5Iy1mHHXrNhejZBXlz6LtO86-CeTFjzA6HwU44l2yqQWlF-X9BkEqB5KqCr_4CH-aSprqE6RhlXEux68YPkEtzzgmDWac42rQ1QM0uNrPLxOwyMZqZfWzmttpeHnuXuxH9yXTMqeqvj7rNzg4h2ZpTPmFcasWAVezygGG97CZiMnmfAvqY6vmNn-O_5_gD1e2zxg</recordid><startdate>19930415</startdate><enddate>19930415</enddate><creator>Herskowitz, Ahvie</creator><creator>Vlahov, David</creator><creator>Willoughby, Sharon</creator><creator>Chaisson, Richard E.</creator><creator>Schulman, Steven P.</creator><creator>Neumann, David A.</creator><creator>Baughman, Kenneth L.</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19930415</creationdate><title>Prevalence and incidence of left ventricular dysfunction in patients with human immunodeficiency virus infection</title><author>Herskowitz, Ahvie ; Vlahov, David ; Willoughby, Sharon ; Chaisson, Richard E. ; Schulman, Steven P. ; Neumann, David A. ; Baughman, Kenneth L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-ae53a977978df09153185116c5d3fc4613b081928145fd29756a432e2ed945573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adult</topic><topic>AIDS/HIV</topic><topic>Biological and medical sciences</topic><topic>Cardiomyopathy, Dilated - diagnostic imaging</topic><topic>Cardiomyopathy, Dilated - epidemiology</topic><topic>Cardiomyopathy, Dilated - physiopathology</topic><topic>Cardiovascular disease</topic><topic>Echocardiography</topic><topic>Female</topic><topic>HIV</topic><topic>HIV Infections - complications</topic><topic>HIV Infections - physiopathology</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Incidence</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Prevalence</topic><topic>Prospective Studies</topic><topic>Ventricular Function, Left</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Herskowitz, Ahvie</creatorcontrib><creatorcontrib>Vlahov, David</creatorcontrib><creatorcontrib>Willoughby, Sharon</creatorcontrib><creatorcontrib>Chaisson, Richard E.</creatorcontrib><creatorcontrib>Schulman, Steven P.</creatorcontrib><creatorcontrib>Neumann, David A.</creatorcontrib><creatorcontrib>Baughman, Kenneth L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Herskowitz, Ahvie</au><au>Vlahov, David</au><au>Willoughby, Sharon</au><au>Chaisson, Richard E.</au><au>Schulman, Steven P.</au><au>Neumann, David A.</au><au>Baughman, Kenneth L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence and incidence of left ventricular dysfunction in patients with human immunodeficiency virus infection</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>1993-04-15</date><risdate>1993</risdate><volume>71</volume><issue>11</issue><spage>955</spage><epage>958</epage><pages>955-958</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><coden>AJCDAG</coden><abstract>The prevalence and incidence of left ventricular (LV) dysfunction was examined in patients infected with the human immunodeficiency virus (HIV). Sixty-nine randomly selected patients diagnosed with HIV infection who were followed in HIV clinics were prospectively evaluated by 2-dimensional echocardiography. Mean follow-up duration was 11 months. Additionally, 39 consecutive HIV-infected patients referred to the Cardiomyopathy Service and found to have LV dysfunction by 2-dimensional echocardiography were also studied. Of the 39 referred patients, 34 (87%) were referred for recent onset, unexplained, congestive heart failure. During this time, the HIV clinic population comprised 1,819 alive and actively followed patients; the 39 cardiomyopathy referrals therefore constituted a crude rate of 2.1% for this population. Of the 69 prospectively studied patients without clinical heart disease, a 14.5% prevalence of global LV hypokinesia and an incidence of 18%/patient-year were found. During a maximal 18-month follow-up period, 4 prospective patients (5.8%) developed symptoms of congestive heart failure. A greater proportion of prospective and referred patients with LV dysfunction had CD4 counts <100/mm
3 (62 and 79%, respectively) than did that of those without LV dysfunction (35%). In conclusion, the high rate of unexpected LV dysfunction in this HIV-infected population suggests that early cardiac contractile abnormalities may involve a significant number of patients, most of whom have low CD4 counts. A subgroup of these patients appears to progress to symptomatic congestive heart failure.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8465788</pmid><doi>10.1016/0002-9149(93)90913-W</doi><tpages>4</tpages></addata></record> |
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| ispartof | The American journal of cardiology, 1993-04, Vol.71 (11), p.955-958 |
| issn | 0002-9149 1879-1913 |
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| subjects | Adult AIDS/HIV Biological and medical sciences Cardiomyopathy, Dilated - diagnostic imaging Cardiomyopathy, Dilated - epidemiology Cardiomyopathy, Dilated - physiopathology Cardiovascular disease Echocardiography Female HIV HIV Infections - complications HIV Infections - physiopathology Human immunodeficiency virus Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Incidence Male Medical research Medical sciences Prevalence Prospective Studies Ventricular Function, Left |
| title | Prevalence and incidence of left ventricular dysfunction in patients with human immunodeficiency virus infection |
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