Plasma Concentrations of 11-Deoxycorticosterone in Women During the Menstrual Cycle

As plasma 11-deoxycorticosterone (DOC) can arise from adrenal secretion and from 21-hydroxylation of plasma progesterone in extraadrenal tissues, alterations in plasma progesterone concentrations might alter significantly the plasma DOC levels in humans. Therefore, the authors measured DOC in plasma of 6 normal, ovulatory women daily throughout their menstrual cycles and in plasma of normal men. The plasma DOC concentrations in women during the follicular phase, when plasma progesterone levels are low, were also low (42 ± 1.7 pg/ml, mean ± SE). An increase in the plasma levels of DOC and progesterone occurred at midcycle. The plasma DOC levels remained elevated (P