BLV-infected lymphocytes exhibit two patterns of expression as determined by Ig and CD5 markers
Lymphocytes were defined by their cell surface markers, Ig and CD5 in three groups of cows naturally infected with bovine leucosis virus (BLV). Lymphocytes were enumerated and groups were designated BLV seropositive with persistent lymphocytosis (BLV+PL+), BLV seropositive without persistent lymphoc...
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| Veröffentlicht in: | Veterinary immunology and immunopathology 1993-03, Vol.36 (2), p.179-186 |
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| creator | Meirom, R. Brenner, J. Trainin, Z. |
| description | Lymphocytes were defined by their cell surface markers, Ig and CD5 in three groups of cows naturally infected with bovine leucosis virus (BLV). Lymphocytes were enumerated and groups were designated BLV seropositive with persistent lymphocytosis (BLV+PL+), BLV seropositive without persistent lymphocytosis (BLV+PL−) and BLV negative. The competence of peripheral blood mononuclear cells (PBMC) from the tested cows to express these two markers was determined by the double staining immunofluorescence procedure. Cows which developed persistent lymphocytosis (PL) as a result of BLV infection consequently underwent massive proliferation of B lymphocytes which express both Ig and CD5 antigens. In contrast, cows which were defined as BLV positive and PL negative showed a remarkable decrease of CD5+Ig−, CD5−Ig+ and CD5+Ig+ cells and also in the total number of lymphocytes.
We suggest that BLV infection affects bovine lymphocytes through two different pathways of expression which might be related to the genetic properties of the target cells. |
| doi_str_mv | 10.1016/0165-2427(93)90106-E |
| format | Article |
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We suggest that BLV infection affects bovine lymphocytes through two different pathways of expression which might be related to the genetic properties of the target cells.</description><identifier>ISSN: 0165-2427</identifier><identifier>EISSN: 1873-2534</identifier><identifier>DOI: 10.1016/0165-2427(93)90106-E</identifier><identifier>PMID: 7682745</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>AIDS/HIV ; Animals ; ANTIGENE ; ANTIGENOS ; ANTIGENS ; Antigens, CD - biosynthesis ; Biological and medical sciences ; Biomarkers ; bovine leukemia virus ; BOVINE LEUKOSIS ; Cattle ; CD5 Antigens ; COWS ; Enzootic Bovine Leukosis - immunology ; Enzootic Bovine Leukosis - pathology ; Female ; Flow Cytometry ; Fundamental and applied biological sciences. Psychology ; IMMUNOFLUORESCENCE ; Immunoglobulins - biosynthesis ; INMUNOFLUORESCENCIA ; LEUCOSE BOVINE ; LEUCOSIS BOVINA ; Leukemia Virus, Bovine - immunology ; Leukocyte Count ; LINFOCITOS ; LYMPHOCYTE ; LYMPHOCYTES ; Lymphocytes - immunology ; Lymphocytes - microbiology ; Microbiology ; Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains ; RETROVIRIDAE ; VACA ; VACHE ; Virology</subject><ispartof>Veterinary immunology and immunopathology, 1993-03, Vol.36 (2), p.179-186</ispartof><rights>1993</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c351t-182440da40b25b6f434d973eeb6511aa1c8e0c2866c760c441075b32256b09dd3</citedby><cites>FETCH-LOGICAL-c351t-182440da40b25b6f434d973eeb6511aa1c8e0c2866c760c441075b32256b09dd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/016524279390106E$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4661270$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7682745$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Meirom, R.</creatorcontrib><creatorcontrib>Brenner, J.</creatorcontrib><creatorcontrib>Trainin, Z.</creatorcontrib><title>BLV-infected lymphocytes exhibit two patterns of expression as determined by Ig and CD5 markers</title><title>Veterinary immunology and immunopathology</title><addtitle>Vet Immunol Immunopathol</addtitle><description>Lymphocytes were defined by their cell surface markers, Ig and CD5 in three groups of cows naturally infected with bovine leucosis virus (BLV). Lymphocytes were enumerated and groups were designated BLV seropositive with persistent lymphocytosis (BLV+PL+), BLV seropositive without persistent lymphocytosis (BLV+PL−) and BLV negative. The competence of peripheral blood mononuclear cells (PBMC) from the tested cows to express these two markers was determined by the double staining immunofluorescence procedure. Cows which developed persistent lymphocytosis (PL) as a result of BLV infection consequently underwent massive proliferation of B lymphocytes which express both Ig and CD5 antigens. In contrast, cows which were defined as BLV positive and PL negative showed a remarkable decrease of CD5+Ig−, CD5−Ig+ and CD5+Ig+ cells and also in the total number of lymphocytes.
We suggest that BLV infection affects bovine lymphocytes through two different pathways of expression which might be related to the genetic properties of the target cells.</description><subject>AIDS/HIV</subject><subject>Animals</subject><subject>ANTIGENE</subject><subject>ANTIGENOS</subject><subject>ANTIGENS</subject><subject>Antigens, CD - biosynthesis</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>bovine leukemia virus</subject><subject>BOVINE LEUKOSIS</subject><subject>Cattle</subject><subject>CD5 Antigens</subject><subject>COWS</subject><subject>Enzootic Bovine Leukosis - immunology</subject><subject>Enzootic Bovine Leukosis - pathology</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>IMMUNOFLUORESCENCE</subject><subject>Immunoglobulins - biosynthesis</subject><subject>INMUNOFLUORESCENCIA</subject><subject>LEUCOSE BOVINE</subject><subject>LEUCOSIS BOVINA</subject><subject>Leukemia Virus, Bovine - immunology</subject><subject>Leukocyte Count</subject><subject>LINFOCITOS</subject><subject>LYMPHOCYTE</subject><subject>LYMPHOCYTES</subject><subject>Lymphocytes - immunology</subject><subject>Lymphocytes - microbiology</subject><subject>Microbiology</subject><subject>Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains</subject><subject>RETROVIRIDAE</subject><subject>VACA</subject><subject>VACHE</subject><subject>Virology</subject><issn>0165-2427</issn><issn>1873-2534</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU-rEzEUxYMoz_r0C4hCFiK6GM3_ZDaC1qoPim7Ubcgkd96LzkzGZKr225va0qUuQiDndy435yD0iJIXlFD1sh7ZMMH0s5Y_bwklqtncQitqNG-Y5OI2Wp2Ru-heKd8IIbI15gJdaGWYFnKF7Jvt1yZOPfgFAh7243yT_H6BguH3TezigpdfCc9uWSBPBae-vs8ZSolpwq7gAFUY41TN3R5fXWM3Bbx-K_Ho8nfI5T6607uhwIPTfYm-vNt8Xn9otp_eX61fbxvPJV0aapgQJDhBOiY71QsuQqs5QKckpc5Rb4B4ZpTyWhEvBCVadpwxqTrShsAv0dPj3DmnHzsoix1j8TAMboK0K1ZLZQSV8r8gVcK0dZ0KiiPocyolQ2_nHOuv9pYSeyjAHtK1h3Rty-3fAuym2h6f5u-6EcLZdEq86k9OuiveDX12k4_ljAmlKNOkYg-PWO-Sdde5Ih-3LSeMqMOMV0cRaqI_I2RbfITJQ4i5FmlDiv9e8g-K1ahO</recordid><startdate>199303</startdate><enddate>199303</enddate><creator>Meirom, R.</creator><creator>Brenner, J.</creator><creator>Trainin, Z.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>199303</creationdate><title>BLV-infected lymphocytes exhibit two patterns of expression as determined by Ig and CD5 markers</title><author>Meirom, R. ; Brenner, J. ; Trainin, Z.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c351t-182440da40b25b6f434d973eeb6511aa1c8e0c2866c760c441075b32256b09dd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>AIDS/HIV</topic><topic>Animals</topic><topic>ANTIGENE</topic><topic>ANTIGENOS</topic><topic>ANTIGENS</topic><topic>Antigens, CD - biosynthesis</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>bovine leukemia virus</topic><topic>BOVINE LEUKOSIS</topic><topic>Cattle</topic><topic>CD5 Antigens</topic><topic>COWS</topic><topic>Enzootic Bovine Leukosis - immunology</topic><topic>Enzootic Bovine Leukosis - pathology</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>IMMUNOFLUORESCENCE</topic><topic>Immunoglobulins - biosynthesis</topic><topic>INMUNOFLUORESCENCIA</topic><topic>LEUCOSE BOVINE</topic><topic>LEUCOSIS BOVINA</topic><topic>Leukemia Virus, Bovine - immunology</topic><topic>Leukocyte Count</topic><topic>LINFOCITOS</topic><topic>LYMPHOCYTE</topic><topic>LYMPHOCYTES</topic><topic>Lymphocytes - immunology</topic><topic>Lymphocytes - microbiology</topic><topic>Microbiology</topic><topic>Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains</topic><topic>RETROVIRIDAE</topic><topic>VACA</topic><topic>VACHE</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meirom, R.</creatorcontrib><creatorcontrib>Brenner, J.</creatorcontrib><creatorcontrib>Trainin, Z.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary immunology and immunopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meirom, R.</au><au>Brenner, J.</au><au>Trainin, Z.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>BLV-infected lymphocytes exhibit two patterns of expression as determined by Ig and CD5 markers</atitle><jtitle>Veterinary immunology and immunopathology</jtitle><addtitle>Vet Immunol Immunopathol</addtitle><date>1993-03</date><risdate>1993</risdate><volume>36</volume><issue>2</issue><spage>179</spage><epage>186</epage><pages>179-186</pages><issn>0165-2427</issn><eissn>1873-2534</eissn><abstract>Lymphocytes were defined by their cell surface markers, Ig and CD5 in three groups of cows naturally infected with bovine leucosis virus (BLV). Lymphocytes were enumerated and groups were designated BLV seropositive with persistent lymphocytosis (BLV+PL+), BLV seropositive without persistent lymphocytosis (BLV+PL−) and BLV negative. The competence of peripheral blood mononuclear cells (PBMC) from the tested cows to express these two markers was determined by the double staining immunofluorescence procedure. Cows which developed persistent lymphocytosis (PL) as a result of BLV infection consequently underwent massive proliferation of B lymphocytes which express both Ig and CD5 antigens. In contrast, cows which were defined as BLV positive and PL negative showed a remarkable decrease of CD5+Ig−, CD5−Ig+ and CD5+Ig+ cells and also in the total number of lymphocytes.
We suggest that BLV infection affects bovine lymphocytes through two different pathways of expression which might be related to the genetic properties of the target cells.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>7682745</pmid><doi>10.1016/0165-2427(93)90106-E</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | AIDS/HIV Animals ANTIGENE ANTIGENOS ANTIGENS Antigens, CD - biosynthesis Biological and medical sciences Biomarkers bovine leukemia virus BOVINE LEUKOSIS Cattle CD5 Antigens COWS Enzootic Bovine Leukosis - immunology Enzootic Bovine Leukosis - pathology Female Flow Cytometry Fundamental and applied biological sciences. Psychology IMMUNOFLUORESCENCE Immunoglobulins - biosynthesis INMUNOFLUORESCENCIA LEUCOSE BOVINE LEUCOSIS BOVINA Leukemia Virus, Bovine - immunology Leukocyte Count LINFOCITOS LYMPHOCYTE LYMPHOCYTES Lymphocytes - immunology Lymphocytes - microbiology Microbiology Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains RETROVIRIDAE VACA VACHE Virology |
| title | BLV-infected lymphocytes exhibit two patterns of expression as determined by Ig and CD5 markers |
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