PACE/furin can process the vitamin K-dependent pro-factor IX precursor within the secretory pathway

Factor IX is synthesized as a precursor polypeptide which requires proteolytic cleavage of the propeptide for functional activity. Expression of factor IX at high levels in Chinese hamster ovary (CHO) cells results in the secretion of a mixture of profactor IX and mature factor IX. We have studied w...

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Veröffentlicht in:	The Journal of biological chemistry 1993-04, Vol.268 (12), p.8458-8465
Hauptverfasser:	WASLEY, L. C, REHEMTULLA, A, BRISTOL, J. A, KAUFMAN, R. J
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha 1-Antitrypsin - metabolism Animals Biological and medical sciences CHO Cells coagulation factor IX Cricetinae dependent Electrophoresis, Polyacrylamide Gel expression Factor IX - metabolism Fundamental and applied biological sciences. Psychology Furin Molecular and cellular biology Molecular genetics mutation paired basic amino acid cleaving enzyme precursors processing Protein Precursors - metabolism Protein Processing, Post-Translational specificity Subtilisins - metabolism Transfection Translation. Translation factors. Protein processing vitamin K Vitamin K - metabolism
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