Molecular Basis for Specific Recognition of Both RNA and DNA by a Zinc Finger Protein

Transcription factor IIIA (TFIIIA) from Xenopus oocytes binds both the internal control region of the 5S ribosomal RNA genes and the 5S RNA transcript itself. The nucleic acid binding domain of TFIIIA contains nine tandemly repeated zinc finger motifs. A series of precisely truncated forms of this p...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1993-04, Vol.260 (5107), p.530-533
Hauptverfasser:	Clemens, Karen R., Wolf, Veronica, McBryant, Steven J., Zhang, Penghua, Liao, Xiubei, Wright, Peter E., Gottesfeld, Joel M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino acids Analytical, structural and metabolic biochemistry Animals Base Sequence Binding and carrier proteins Binding sites Biological and medical sciences Carrier proteins DNA DNA - metabolism DNA binding proteins DNA-Binding Proteins - metabolism Female Freshwater Fundamental and applied biological sciences. Psychology Gels Genetic mutation Genetic transcription Molecular Sequence Data Nucleic Acid Conformation Nucleic acids Nucleotides Oocytes - chemistry Proteins RNA RNA, Ribosomal, 5S - metabolism Titration Transcription (Genetics) Transcription Factor TFIIIA Transcription Factors - chemistry Transcription Factors - metabolism Transport proteins Xenopus Zinc Zinc Fingers - physiology
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