Baculovirus-expressed herpes simplex virus type 2 glycoprotein D is immunogenic and protective against lethal HSV challenge

Herpes simplex virus type 2 glycoprotein D (gD2) was cloned and expressed in the baculovirus— Spodoptera frugiperda system. Milligram quantities of glycoprotein were recovered from suspension culture and subjected to purification by ion-exchange and immunoaffinity chromatography. The resultant purif...

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Veröffentlicht in:	Vaccine 1993, Vol.11 (4), p.407-414
Hauptverfasser:	Landolfi, V., Zarley, C.D., Abramovitz, A.S., Figueroa, N., Wu, S.L., Blasiak, M., Ishizaka, S.T., Mishkin, E.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Viral - biosynthesis Baculoviridae - genetics baculovirus baculovirus expression Biological and medical sciences Cell Line Cloning, Molecular Female Fundamental and applied biological sciences. Psychology Fundamental immunology Gene Expression glycoprotein D Herpes Simplex - prevention & control Herpes simplex virus herpes simplex virus 2 Immunobiology immunogenicity Immunological tolerance In Vitro Techniques Lymphocyte Activation Mice Mice, Inbred BALB C Moths Neutralization Tests protectivity Simplexvirus - genetics Simplexvirus - immunology T-Lymphocytes - immunology Viral Envelope Proteins - genetics Viral Envelope Proteins - immunology Viral Envelope Proteins - isolation & purification
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