Effects of phenytoin on mouse cerebellar 5-hydroxytryptamine and norepinephrine

Concentrations of 5-hydroxytryptamine and norepinephrine in mouse cerebellums have been determined at six time intervals after a single intraperitoneal injection of phenytoin, 20 mg/kg. Compared to controls, where phenytoin diluent was injected two hours before the cerebellums were taken, 5-hydroxyt...

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Veröffentlicht in:	Neuropharmacology 1981-06, Vol.20 (6), p.623-625
Hauptverfasser:	Fry, B.W., Ciarlone, A.E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cerebellum - drug effects Cerebellum - metabolism Injections, Intraperitoneal Male Mice Norepinephrine - metabolism Phenytoin - administration & dosage Phenytoin - pharmacology Serotonin - metabolism
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creator	Fry, B.W. Ciarlone, A.E.
description	Concentrations of 5-hydroxytryptamine and norepinephrine in mouse cerebellums have been determined at six time intervals after a single intraperitoneal injection of phenytoin, 20 mg/kg. Compared to controls, where phenytoin diluent was injected two hours before the cerebellums were taken, 5-hydroxytryptamine concentrations were 98%, 122%, 104%, 105%, 112% and 120% at 2, 4, 10, 16, 22, and 28 hours, respectively. At the same times norepinephrine concentrations were 102%, 111%, 116%, 96%, 94% and 120% of the control value. Increases of these brain amines, which are primarily inhibitory within the central nervous system, may be related to the anticonvulsant effect of phenytoin.
doi_str_mv	10.1016/0028-3908(81)90218-5
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Increases of these brain amines, which are primarily inhibitory within the central nervous system, may be related to the anticonvulsant effect of phenytoin.</description><subject>Animals</subject><subject>Cerebellum - drug effects</subject><subject>Cerebellum - metabolism</subject><subject>Injections, Intraperitoneal</subject><subject>Male</subject><subject>Mice</subject><subject>Norepinephrine - metabolism</subject><subject>Phenytoin - administration & dosage</subject><subject>Phenytoin - pharmacology</subject><subject>Serotonin - metabolism</subject><issn>0028-3908</issn><issn>1873-7064</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLxDAQx4Mouj6-gUJPoofq5NVkL4IsvkDYi55Dmk7YyrapSVfst7d1F49eZhj-_3n9CDmncEOBFrcATOd8DvpK0-s5MKpzuUdmVCueKyjEPpn9WY7IcUofACA01YfkUDHBtFIzsnzwHl2fsuCzboXt0Ie6zUKbNWGTMHMYscT12sZM5quhiuF76OPQ9bapW8xsW2VtiNiNRbeKYzwlB96uE57t8gl5f3x4Wzznr8unl8X9a-64VH0uGEPnwSo2B-kFw7Lyc8WsRFo4wQvhuC1pCRIcVNpLQUVlC1GoAjXX4PkJudzO7WL43GDqTVMnN13a4ni5UbLQnEs5GsXW6GJIKaI3XawbGwdDwUwczQTJTJCMpuaXo5naLnbzN2WD1V_TDtyo3211HJ_8qjGa5GpsHVZ1HHmaKtT_L_gBbuuCWg</recordid><startdate>198106</startdate><enddate>198106</enddate><creator>Fry, B.W.</creator><creator>Ciarlone, A.E.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198106</creationdate><title>Effects of phenytoin on mouse cerebellar 5-hydroxytryptamine and norepinephrine</title><author>Fry, B.W. ; Ciarlone, A.E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-422ecf0a72905f42ebdf972a5e16c4364c3ab1b050c0d8f5414da64676e8380f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Animals</topic><topic>Cerebellum - drug effects</topic><topic>Cerebellum - metabolism</topic><topic>Injections, Intraperitoneal</topic><topic>Male</topic><topic>Mice</topic><topic>Norepinephrine - metabolism</topic><topic>Phenytoin - administration & dosage</topic><topic>Phenytoin - pharmacology</topic><topic>Serotonin - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fry, B.W.</creatorcontrib><creatorcontrib>Ciarlone, A.E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuropharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fry, B.W.</au><au>Ciarlone, A.E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of phenytoin on mouse cerebellar 5-hydroxytryptamine and norepinephrine</atitle><jtitle>Neuropharmacology</jtitle><addtitle>Neuropharmacology</addtitle><date>1981-06</date><risdate>1981</risdate><volume>20</volume><issue>6</issue><spage>623</spage><epage>625</epage><pages>623-625</pages><issn>0028-3908</issn><eissn>1873-7064</eissn><abstract>Concentrations of 5-hydroxytryptamine and norepinephrine in mouse cerebellums have been determined at six time intervals after a single intraperitoneal injection of phenytoin, 20 mg/kg. 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subjects	Animals Cerebellum - drug effects Cerebellum - metabolism Injections, Intraperitoneal Male Mice Norepinephrine - metabolism Phenytoin - administration & dosage Phenytoin - pharmacology Serotonin - metabolism
title	Effects of phenytoin on mouse cerebellar 5-hydroxytryptamine and norepinephrine
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