Characteristics and regulation of high affinity [ 3H]imipramine binding to rat hippocampal membranes

The imipramine binding sites located in the membrane of the rat hippocampus have been characterized in order to obtain a better understanding of their role in the treatment of mental depression. The binding of [ 3H]imipramine to hippocampal membranes has a K d of 8.3 ± 1.5 nM, B max of 800 ± 60 fmol...

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Veröffentlicht in:	Neuropharmacology 1981-05, Vol.20 (5), p.411-419
Hauptverfasser:	Kinnier, W.J., Chuang, D.-M., Gwynn, Germaine, Costa, E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carrier Proteins Cell Line Cell Membrane - metabolism Hippocampus - metabolism Imipramine - metabolism In Vitro Techniques Kinetics Leupeptins - pharmacology Neuroblastoma Phospholipases A - pharmacology Pronase - pharmacology Rats Receptors, Drug - drug effects Receptors, Drug - metabolism Temperature
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