Automated Drug Dissolution Monitor That Uses a UV-Visible Diode Array Spectrophotometer
A method for performing multicomponent analysis in drug dissolution testing without chromatographic separation is presented. Aliquots from dissolution vessels are automatically transferred to a UV-visible diode array spectrophotometer, spectra are measured, and the aliquots are returned to the testi...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1993-04, Vol.82 (4), p.350-354 |
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| Format: | Artikel |
| Sprache: | eng |
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| container_end_page | 354 |
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| container_issue | 4 |
| container_start_page | 350 |
| container_title | Journal of pharmaceutical sciences |
| container_volume | 82 |
| creator | Lo, Su-Chin Donahue, Steven M. Brown, Chris W. |
| description | A method for performing multicomponent analysis in drug dissolution testing without chromatographic separation is presented. Aliquots from dissolution vessels are automatically transferred to a UV-visible diode array spectrophotometer, spectra are measured, and the aliquots are returned to the testing vessels. A full-spectrum calibration method based on principal-component regression is used to simultaneously determine the concentrations of active ingredients and to account for interferences due to excipients in a tablet formulation. The system was evaluated with two commercial pharmaceutical formularies; the first contained pseudoephedrine hydrochloride and chlorpheniramine maleate, whereas the second was a mixture of phenylpropanolamine hydrochloride and chlorpheniramine maleate. The selections of standard mixtures for calibration and validation were based on a factorial design. |
| doi_str_mv | 10.1002/jps.2600820403 |
| format | Article |
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Pharm. Sci</addtitle><description>A method for performing multicomponent analysis in drug dissolution testing without chromatographic separation is presented. Aliquots from dissolution vessels are automatically transferred to a UV-visible diode array spectrophotometer, spectra are measured, and the aliquots are returned to the testing vessels. A full-spectrum calibration method based on principal-component regression is used to simultaneously determine the concentrations of active ingredients and to account for interferences due to excipients in a tablet formulation. The system was evaluated with two commercial pharmaceutical formularies; the first contained pseudoephedrine hydrochloride and chlorpheniramine maleate, whereas the second was a mixture of phenylpropanolamine hydrochloride and chlorpheniramine maleate. The selections of standard mixtures for calibration and validation were based on a factorial design.</description><subject>Biological and medical sciences</subject><subject>Calibration</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>Pharmaceutical Preparations - chemistry</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. 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Drug treatments</topic><topic>Solubility</topic><topic>Spectrophotometry, Ultraviolet</topic><topic>Tablets</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lo, Su-Chin</creatorcontrib><creatorcontrib>Donahue, Steven M.</creatorcontrib><creatorcontrib>Brown, Chris W.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lo, Su-Chin</au><au>Donahue, Steven M.</au><au>Brown, Chris W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Automated Drug Dissolution Monitor That Uses a UV-Visible Diode Array Spectrophotometer</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1993-04</date><risdate>1993</risdate><volume>82</volume><issue>4</issue><spage>350</spage><epage>354</epage><pages>350-354</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><coden>JPMSAE</coden><abstract>A method for performing multicomponent analysis in drug dissolution testing without chromatographic separation is presented. Aliquots from dissolution vessels are automatically transferred to a UV-visible diode array spectrophotometer, spectra are measured, and the aliquots are returned to the testing vessels. A full-spectrum calibration method based on principal-component regression is used to simultaneously determine the concentrations of active ingredients and to account for interferences due to excipients in a tablet formulation. 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| fulltext | fulltext |
| identifier | ISSN: 0022-3549 |
| ispartof | Journal of pharmaceutical sciences, 1993-04, Vol.82 (4), p.350-354 |
| issn | 0022-3549 1520-6017 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75682004 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Biological and medical sciences Calibration General pharmacology Medical sciences Pharmaceutical Preparations - chemistry Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Solubility Spectrophotometry, Ultraviolet Tablets |
| title | Automated Drug Dissolution Monitor That Uses a UV-Visible Diode Array Spectrophotometer |
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