Production of an interleukin-8-like chemokine by cytokine-stimulated rat NRK-49F fibroblasts and its suppression by anti-inflammatory steroids

Normal rat kidney fibroblasts (NRK-49F cells) stimulated with interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) produced mainly cytokine-induced neutrophil chemoattractant (CINC) which is the rat counterpart of human gro/melanoma growth stimulatory activity. In addition, the cytokine-stimul...

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Veröffentlicht in:	Biochemical pharmacology 1993-04, Vol.45 (7), p.1425-1430
Hauptverfasser:	Hideo, Nakagawa, Atsutoshi, Ikesue, Sinji, Hatakeyama, Hideko, Kato, Takuya, Gotoda, Naruyasu, Komorita, Kazuyoshi, Watanabe, Hisato, Miyai
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Analysis of the immune response. Humoral and cellular immunity Animals Anti-Inflammatory Agents - pharmacology Biological and medical sciences Cell Line - drug effects Chemokine CXCL1 Chemokine CXCL2 Chemokines, CXC Chemotactic Factors - biosynthesis Fibroblasts - drug effects Fundamental and applied biological sciences. Psychology Fundamental immunology Growth Substances - biosynthesis Immunobiology Intercellular Signaling Peptides and Proteins Interleukin-1 - antagonists & inhibitors Interleukin-1 - pharmacology Interleukin-8 - biosynthesis Lymphokines, interleukins ( function, expression) Molecular Sequence Data Rats Recombinant Proteins - pharmacology Regulatory factors and their cellular receptors Steroids Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - pharmacology
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