Studies of the nuclear 5α-reductase of human hyperplastic prostatic tissue

The 5α-reduction of testosterone was studied using the nuclear fraction of hyperplastic human prostatic tissue. Standard assay conditions were: non-radioactive testosterone (4 μM) plus 3.0–4.0 × 10 5 d.p.m. [ 3H]-testosterone, 0.4 mM NADPH, 2.0 mM EDTA and the nuclear fraction equivalent to 200 mg o...

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Veröffentlicht in:	Journal of steroid biochemistry 1981-06, Vol.14 (6), p.579-584
1. Verfasser:	Hudson, Robert W.
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism Androstenedione - metabolism Biotransformation Cell Nucleus - enzymology Cyproterone - pharmacology Dihydrotestosterone - metabolism Humans Hydrogen-Ion Concentration Kinetics Male Oxidoreductases - metabolism Prostatic Hyperplasia - enzymology Proteins - metabolism
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