Influence of hyperkalaemia and ischaemia on non-receptor-mediated cardiac electrophysiological effects of naloxone

Objective: The aim was to investigate the cardiac electrophysiological effects of the opioid receptor antagonist naloxone and examine whether hyperkalaemia and ischaemia influence these effects. Methods: The cardiac electrophysiological effects of racemic naloxone, nalmafene, and morphine were exami...

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Veröffentlicht in:	Cardiovascular research 1993-02, Vol.27 (2), p.296-303
Hauptverfasser:	Oldroyd, Keith G, Hicks, Martin N, Cobbe, Stuart M
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Animals Biological and medical sciences Culture Techniques Dose-Response Relationship, Drug Electrocardiography. Vectocardiography Electrodiagnosis. Electric activity recording Electrophysiology Heart Conduction System - drug effects hyperkalaemia Hyperkalemia - physiopathology Investigative techniques, diagnostic techniques (general aspects) ischaemia Medical sciences Morphine - pharmacology Myocardial Ischemia - physiopathology naloxone Naloxone - pharmacology Naltrexone - analogs & derivatives Naltrexone - pharmacology Narcotic Antagonists - pharmacology opioids Rabbits Refractory Period, Electrophysiological - drug effects
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