Oxygen affinities of metronidazole-resistant and -sensitive stocks of Giardia intestinalis

The common protozoon, Giardia intestinalis, parasitizes the upper small intestine of man, and is often refractory to treatment by metronidazole. Defective oxygen-scavenging mechanisms have been implicated as a cause of metronidazole resistance of another flagellate Trichomonas vaginalis, where metro...

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Veröffentlicht in:	International journal for parasitology 1993-02, Vol.23 (1), p.35-39
Hauptverfasser:	Ellis, Jayne E., Wingfield, Jonathan M., Cole, Deborah, Boreham, Peter F.L., Lloyd, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiparasitic agents Biological and medical sciences Drug Resistance ferredoxin oxidoreductase Giardia intestinalis Giardia intestinalis, oxygen affinities Giardia lamblia - drug effects Giardia lamblia - enzymology Humans Medical sciences metronidazole Metronidazole - metabolism Metronidazole - pharmacology NADH, NADPH Oxidoreductases - metabolism NADPH Oxidases Oxygen Consumption Pharmacology. Drug treatments pyruvate
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