Mechanical stimulation of skeletal muscle generates lipid-related second messengers by phospholipase activation

Repetitive mechanical stimulation of cultured avian skeletal muscle increases the synthesis of prostaglandins (PG) E2 and F2 alpha which regulate protein turnover rates and muscle cell growth. These stretch-induced PG increases are reduced in low extracellular calcium medium and by specific phosphol...

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Veröffentlicht in:Journal of cellular physiology 1993-04, Vol.155 (1), p.63-71
Hauptverfasser: Vandenburgh, Herman H., Shansky, Janet, Karlisch, Patricia, Solerssi, Rosa Lopez
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container_title Journal of cellular physiology
container_volume 155
creator Vandenburgh, Herman H.
Shansky, Janet
Karlisch, Patricia
Solerssi, Rosa Lopez
description Repetitive mechanical stimulation of cultured avian skeletal muscle increases the synthesis of prostaglandins (PG) E2 and F2 alpha which regulate protein turnover rates and muscle cell growth. These stretch-induced PG increases are reduced in low extracellular calcium medium and by specific phospholipase inhibitors. Mechanical stimulation increases the breakdown rate of 3H-arachidonic acid labelled phospholipids, releasing free 3H-arachidonic acid, the rate-limiting precursor of PG synthesis. Mechanical stimulation also increases 3H-arachidonic acid labelled diacylglycerol formation and intracellular levels of inositol phosphates from myo-[2-3H]inositol labelled phospholipids. Phospholipase A2 (PLA2), phosphatidylinositol-specific phospholipase C (PLC), and phospholipase D (PLD) are all activated by stretch. The stretch-induced increases in PG production, 3H-arachidonic acid labelled phospholipid breakdown, and 3H-arachidonic acid labelled diacylglycerol formation occur independently of cellular electrical activity (tetrodotoxin insensitive) whereas the formation of inositol phosphates from myo-[2-3H]inositol labelled phospholipids is dependent on cellular electrical activity. These results indicate that mechanical stimulation increases the lipid-related second messengers arachidonic acid, diacylglycerol, and PG through activation of specific phospholipases such as PLA2 and PLD, but not by activation of phosphatidylinositol-specific PLC.
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These stretch-induced PG increases are reduced in low extracellular calcium medium and by specific phospholipase inhibitors. Mechanical stimulation increases the breakdown rate of 3H-arachidonic acid labelled phospholipids, releasing free 3H-arachidonic acid, the rate-limiting precursor of PG synthesis. Mechanical stimulation also increases 3H-arachidonic acid labelled diacylglycerol formation and intracellular levels of inositol phosphates from myo-[2-3H]inositol labelled phospholipids. Phospholipase A2 (PLA2), phosphatidylinositol-specific phospholipase C (PLC), and phospholipase D (PLD) are all activated by stretch. The stretch-induced increases in PG production, 3H-arachidonic acid labelled phospholipid breakdown, and 3H-arachidonic acid labelled diacylglycerol formation occur independently of cellular electrical activity (tetrodotoxin insensitive) whereas the formation of inositol phosphates from myo-[2-3H]inositol labelled phospholipids is dependent on cellular electrical activity. These results indicate that mechanical stimulation increases the lipid-related second messengers arachidonic acid, diacylglycerol, and PG through activation of specific phospholipases such as PLA2 and PLD, but not by activation of phosphatidylinositol-specific PLC.</description><identifier>ISSN: 0021-9541</identifier><identifier>EISSN: 1097-4652</identifier><identifier>DOI: 10.1002/jcp.1041550109</identifier><identifier>PMID: 8468370</identifier><identifier>CODEN: JCLLAX</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; Biological and medical sciences ; Birds ; Cells, Cultured ; Enzyme Activation ; Fundamental and applied biological sciences. Psychology ; Life Sciences (General) ; Lipid Metabolism ; Muscles - cytology ; Muscles - metabolism ; Phospholipases - metabolism ; Physical Stimulation ; Prostaglandins - biosynthesis ; Second Messenger Systems ; Space life sciences ; Striated muscle. 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Cell. Physiol</addtitle><description>Repetitive mechanical stimulation of cultured avian skeletal muscle increases the synthesis of prostaglandins (PG) E2 and F2 alpha which regulate protein turnover rates and muscle cell growth. These stretch-induced PG increases are reduced in low extracellular calcium medium and by specific phospholipase inhibitors. Mechanical stimulation increases the breakdown rate of 3H-arachidonic acid labelled phospholipids, releasing free 3H-arachidonic acid, the rate-limiting precursor of PG synthesis. Mechanical stimulation also increases 3H-arachidonic acid labelled diacylglycerol formation and intracellular levels of inositol phosphates from myo-[2-3H]inositol labelled phospholipids. Phospholipase A2 (PLA2), phosphatidylinositol-specific phospholipase C (PLC), and phospholipase D (PLD) are all activated by stretch. The stretch-induced increases in PG production, 3H-arachidonic acid labelled phospholipid breakdown, and 3H-arachidonic acid labelled diacylglycerol formation occur independently of cellular electrical activity (tetrodotoxin insensitive) whereas the formation of inositol phosphates from myo-[2-3H]inositol labelled phospholipids is dependent on cellular electrical activity. These results indicate that mechanical stimulation increases the lipid-related second messengers arachidonic acid, diacylglycerol, and PG through activation of specific phospholipases such as PLA2 and PLD, but not by activation of phosphatidylinositol-specific PLC.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Birds</subject><subject>Cells, Cultured</subject><subject>Enzyme Activation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Life Sciences (General)</subject><subject>Lipid Metabolism</subject><subject>Muscles - cytology</subject><subject>Muscles - metabolism</subject><subject>Phospholipases - metabolism</subject><subject>Physical Stimulation</subject><subject>Prostaglandins - biosynthesis</subject><subject>Second Messenger Systems</subject><subject>Space life sciences</subject><subject>Striated muscle. 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Psychology</topic><topic>Life Sciences (General)</topic><topic>Lipid Metabolism</topic><topic>Muscles - cytology</topic><topic>Muscles - metabolism</topic><topic>Phospholipases - metabolism</topic><topic>Physical Stimulation</topic><topic>Prostaglandins - biosynthesis</topic><topic>Second Messenger Systems</topic><topic>Space life sciences</topic><topic>Striated muscle. Tendons</topic><topic>Vertebrates: osteoarticular system, musculoskeletal system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vandenburgh, Herman H.</creatorcontrib><creatorcontrib>Shansky, Janet</creatorcontrib><creatorcontrib>Karlisch, Patricia</creatorcontrib><creatorcontrib>Solerssi, Rosa Lopez</creatorcontrib><collection>Istex</collection><collection>NASA Scientific and Technical Information</collection><collection>NASA Technical Reports Server</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cellular physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vandenburgh, Herman H.</au><au>Shansky, Janet</au><au>Karlisch, Patricia</au><au>Solerssi, Rosa Lopez</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mechanical stimulation of skeletal muscle generates lipid-related second messengers by phospholipase activation</atitle><jtitle>Journal of cellular physiology</jtitle><addtitle>J. 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Phospholipase A2 (PLA2), phosphatidylinositol-specific phospholipase C (PLC), and phospholipase D (PLD) are all activated by stretch. The stretch-induced increases in PG production, 3H-arachidonic acid labelled phospholipid breakdown, and 3H-arachidonic acid labelled diacylglycerol formation occur independently of cellular electrical activity (tetrodotoxin insensitive) whereas the formation of inositol phosphates from myo-[2-3H]inositol labelled phospholipids is dependent on cellular electrical activity. These results indicate that mechanical stimulation increases the lipid-related second messengers arachidonic acid, diacylglycerol, and PG through activation of specific phospholipases such as PLA2 and PLD, but not by activation of phosphatidylinositol-specific PLC.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>8468370</pmid><doi>10.1002/jcp.1041550109</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record>
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subjects Animals
Biological and medical sciences
Birds
Cells, Cultured
Enzyme Activation
Fundamental and applied biological sciences. Psychology
Life Sciences (General)
Lipid Metabolism
Muscles - cytology
Muscles - metabolism
Phospholipases - metabolism
Physical Stimulation
Prostaglandins - biosynthesis
Second Messenger Systems
Space life sciences
Striated muscle. Tendons
Vertebrates: osteoarticular system, musculoskeletal system
title Mechanical stimulation of skeletal muscle generates lipid-related second messengers by phospholipase activation
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