Impairment of V(D)J Recombination in Double-Strand Break Repair Mutants

Cells maintain the integrity of their genome through an intricate network of repair systems that recognize and remove lesions from DNA. The only known site-directed recombination process in vertebrates is the V(D)J recombination of lymphocyte antigen receptor genes. A large panel of cell lines defic...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1993-04, Vol.260 (5105), p.207-210
Hauptverfasser:	Taccioli, Guillermo E., Rathbun, Gary, Oltz, Eugene, Stamato, Thomas, Jeggo, Penny A., Alt, Frederick W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Biological and medical sciences Cell Line Cell lines CHO Cells Cricetinae DNA Nucleotidyltransferases - genetics DNA Nucleotidyltransferases - metabolism DNA Repair Fundamental and applied biological sciences. Psychology Gene Rearrangement, T-Lymphocyte Genes, RAG-1 Genetic mutation Genic rearrangement. Recombination. Transposable element Human chromosomes Hybridity Immunoglobulin Heavy Chains Medical research Molecular and cellular biology Molecular genetics Molecular Sequence Data Mutation Nucleotides Receptors, Antigen, T-Cell - genetics Recombination, Genetic Reed Sternberg cells Transposons VDJ Recombinases
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