Total and specific IgE (RAST) in atopic twins
Summary Fifty sets of twins (thirty monozygotic [MZ] and twenty dizygotic [DZ]), of whom at least one twin had a history of atopy, were investigated by means of skin tests, RAST and IgE determinations. The concordance of atopies for MZ was, with 56.7%, significantly higher as compared with the DZ wi...
Gespeichert in:
| Veröffentlicht in: | Clinical allergy 1981-03, Vol.11 (2), p.147-154 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 154 |
|---|---|
| container_issue | 2 |
| container_start_page | 147 |
| container_title | Clinical allergy |
| container_volume | 11 |
| creator | WÜTHRICH, B. BAUMANN, E. FRIES, R. A. SCHNYDER, U. W. |
| description | Summary
Fifty sets of twins (thirty monozygotic [MZ] and twenty dizygotic [DZ]), of whom at least one twin had a history of atopy, were investigated by means of skin tests, RAST and IgE determinations. The concordance of atopies for MZ was, with 56.7%, significantly higher as compared with the DZ with 20%. The mean values of the log serum IgE level differences for MZ and DZ sets of twins was not statistically significant but the percentage distribution of the log serum IgE level differences showed a closer correlation of the IgE levels among MZ. The MZ sets do not show a better concordance in the specific reagin production, as measured by RAST or skin tests, than the DZ sets. These findings seemed to indicate that although the tendency to IgE production is genetically determined its specificity is governed mainly by environmental influences. |
| doi_str_mv | 10.1111/j.1365-2222.1981.tb01578.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_75669184</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>75669184</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5087-a5058a15f44295865b49a31941bd0bbcff3780a593394655df572de1b356cd373</originalsourceid><addsrcrecordid>eNqVkFtLw0AQhRdRar38BCH4IPqQuNPd2YsPQin1gjeoFcGXZZNsJDVtajal9d-b0NJXcV4G5pw5w3yEnAKNoKnLSQRMYNhrKgKtIKpjCihVtNoh3a20S7pUIw-l0nyfHHg_oZQy1KpDOhI0sh50STgua1sEdpYGfu6SPMuT4P5zGJyP-q_jiyCfBbYu582wXuYzf0T2Mlt4d7zph-TtZjge3IWPL7f3g_5jmCBVMrRIUVnAjPOeRiUw5toy0BzilMZxkmVMKmpRM6a5QEwzlL3UQcxQJCmT7JCcrXPnVfm9cL4209wnrijszJULbyQKoUHxP42ADIQSqjFerY1JVXpfuczMq3xqqx8D1LRQzcS05ExLzrRQzQaqWTXLJ5sri3jq0u3qhmKjX6_1ZV64n38km8GwD7z9N1wH5L52q22Arb6MkEyieX--NeIJPhgfPZgB-wX6qZIW</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>15316868</pqid></control><display><type>article</type><title>Total and specific IgE (RAST) in atopic twins</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><source>Alma/SFX Local Collection</source><creator>WÜTHRICH, B. ; BAUMANN, E. ; FRIES, R. A. ; SCHNYDER, U. W.</creator><creatorcontrib>WÜTHRICH, B. ; BAUMANN, E. ; FRIES, R. A. ; SCHNYDER, U. W.</creatorcontrib><description>Summary
Fifty sets of twins (thirty monozygotic [MZ] and twenty dizygotic [DZ]), of whom at least one twin had a history of atopy, were investigated by means of skin tests, RAST and IgE determinations. The concordance of atopies for MZ was, with 56.7%, significantly higher as compared with the DZ with 20%. The mean values of the log serum IgE level differences for MZ and DZ sets of twins was not statistically significant but the percentage distribution of the log serum IgE level differences showed a closer correlation of the IgE levels among MZ. The MZ sets do not show a better concordance in the specific reagin production, as measured by RAST or skin tests, than the DZ sets. These findings seemed to indicate that although the tendency to IgE production is genetically determined its specificity is governed mainly by environmental influences.</description><identifier>ISSN: 0954-7894</identifier><identifier>ISSN: 0009-9090</identifier><identifier>EISSN: 1365-2222</identifier><identifier>DOI: 10.1111/j.1365-2222.1981.tb01578.x</identifier><identifier>PMID: 7195321</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Antibody Specificity ; Diseases in Twins ; Female ; Humans ; Hypersensitivity, Immediate - diagnosis ; Hypersensitivity, Immediate - immunology ; Immunoglobulin E ; Pregnancy ; Radioallergosorbent Test ; Skin Tests ; Twins, Dizygotic ; Twins, Monozygotic</subject><ispartof>Clinical allergy, 1981-03, Vol.11 (2), p.147-154</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5087-a5058a15f44295865b49a31941bd0bbcff3780a593394655df572de1b356cd373</citedby><cites>FETCH-LOGICAL-c5087-a5058a15f44295865b49a31941bd0bbcff3780a593394655df572de1b356cd373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2222.1981.tb01578.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2222.1981.tb01578.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7195321$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WÜTHRICH, B.</creatorcontrib><creatorcontrib>BAUMANN, E.</creatorcontrib><creatorcontrib>FRIES, R. A.</creatorcontrib><creatorcontrib>SCHNYDER, U. W.</creatorcontrib><title>Total and specific IgE (RAST) in atopic twins</title><title>Clinical allergy</title><addtitle>Clin Allergy</addtitle><description>Summary
Fifty sets of twins (thirty monozygotic [MZ] and twenty dizygotic [DZ]), of whom at least one twin had a history of atopy, were investigated by means of skin tests, RAST and IgE determinations. The concordance of atopies for MZ was, with 56.7%, significantly higher as compared with the DZ with 20%. The mean values of the log serum IgE level differences for MZ and DZ sets of twins was not statistically significant but the percentage distribution of the log serum IgE level differences showed a closer correlation of the IgE levels among MZ. The MZ sets do not show a better concordance in the specific reagin production, as measured by RAST or skin tests, than the DZ sets. These findings seemed to indicate that although the tendency to IgE production is genetically determined its specificity is governed mainly by environmental influences.</description><subject>Antibody Specificity</subject><subject>Diseases in Twins</subject><subject>Female</subject><subject>Humans</subject><subject>Hypersensitivity, Immediate - diagnosis</subject><subject>Hypersensitivity, Immediate - immunology</subject><subject>Immunoglobulin E</subject><subject>Pregnancy</subject><subject>Radioallergosorbent Test</subject><subject>Skin Tests</subject><subject>Twins, Dizygotic</subject><subject>Twins, Monozygotic</subject><issn>0954-7894</issn><issn>0009-9090</issn><issn>1365-2222</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkFtLw0AQhRdRar38BCH4IPqQuNPd2YsPQin1gjeoFcGXZZNsJDVtajal9d-b0NJXcV4G5pw5w3yEnAKNoKnLSQRMYNhrKgKtIKpjCihVtNoh3a20S7pUIw-l0nyfHHg_oZQy1KpDOhI0sh50STgua1sEdpYGfu6SPMuT4P5zGJyP-q_jiyCfBbYu582wXuYzf0T2Mlt4d7zph-TtZjge3IWPL7f3g_5jmCBVMrRIUVnAjPOeRiUw5toy0BzilMZxkmVMKmpRM6a5QEwzlL3UQcxQJCmT7JCcrXPnVfm9cL4209wnrijszJULbyQKoUHxP42ADIQSqjFerY1JVXpfuczMq3xqqx8D1LRQzcS05ExLzrRQzQaqWTXLJ5sri3jq0u3qhmKjX6_1ZV64n38km8GwD7z9N1wH5L52q22Arb6MkEyieX--NeIJPhgfPZgB-wX6qZIW</recordid><startdate>198103</startdate><enddate>198103</enddate><creator>WÜTHRICH, B.</creator><creator>BAUMANN, E.</creator><creator>FRIES, R. A.</creator><creator>SCHNYDER, U. W.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>198103</creationdate><title>Total and specific IgE (RAST) in atopic twins</title><author>WÜTHRICH, B. ; BAUMANN, E. ; FRIES, R. A. ; SCHNYDER, U. W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5087-a5058a15f44295865b49a31941bd0bbcff3780a593394655df572de1b356cd373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Antibody Specificity</topic><topic>Diseases in Twins</topic><topic>Female</topic><topic>Humans</topic><topic>Hypersensitivity, Immediate - diagnosis</topic><topic>Hypersensitivity, Immediate - immunology</topic><topic>Immunoglobulin E</topic><topic>Pregnancy</topic><topic>Radioallergosorbent Test</topic><topic>Skin Tests</topic><topic>Twins, Dizygotic</topic><topic>Twins, Monozygotic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WÜTHRICH, B.</creatorcontrib><creatorcontrib>BAUMANN, E.</creatorcontrib><creatorcontrib>FRIES, R. A.</creatorcontrib><creatorcontrib>SCHNYDER, U. W.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical allergy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WÜTHRICH, B.</au><au>BAUMANN, E.</au><au>FRIES, R. A.</au><au>SCHNYDER, U. W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Total and specific IgE (RAST) in atopic twins</atitle><jtitle>Clinical allergy</jtitle><addtitle>Clin Allergy</addtitle><date>1981-03</date><risdate>1981</risdate><volume>11</volume><issue>2</issue><spage>147</spage><epage>154</epage><pages>147-154</pages><issn>0954-7894</issn><issn>0009-9090</issn><eissn>1365-2222</eissn><abstract>Summary
Fifty sets of twins (thirty monozygotic [MZ] and twenty dizygotic [DZ]), of whom at least one twin had a history of atopy, were investigated by means of skin tests, RAST and IgE determinations. The concordance of atopies for MZ was, with 56.7%, significantly higher as compared with the DZ with 20%. The mean values of the log serum IgE level differences for MZ and DZ sets of twins was not statistically significant but the percentage distribution of the log serum IgE level differences showed a closer correlation of the IgE levels among MZ. The MZ sets do not show a better concordance in the specific reagin production, as measured by RAST or skin tests, than the DZ sets. These findings seemed to indicate that although the tendency to IgE production is genetically determined its specificity is governed mainly by environmental influences.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>7195321</pmid><doi>10.1111/j.1365-2222.1981.tb01578.x</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0954-7894 |
| ispartof | Clinical allergy, 1981-03, Vol.11 (2), p.147-154 |
| issn | 0954-7894 0009-9090 1365-2222 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75669184 |
| source | MEDLINE; Access via Wiley Online Library; Alma/SFX Local Collection |
| subjects | Antibody Specificity Diseases in Twins Female Humans Hypersensitivity, Immediate - diagnosis Hypersensitivity, Immediate - immunology Immunoglobulin E Pregnancy Radioallergosorbent Test Skin Tests Twins, Dizygotic Twins, Monozygotic |
| title | Total and specific IgE (RAST) in atopic twins |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T12%3A08%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Total%20and%20specific%20IgE%20(RAST)%20in%20atopic%20twins&rft.jtitle=Clinical%20allergy&rft.au=W%C3%9CTHRICH,%20B.&rft.date=1981-03&rft.volume=11&rft.issue=2&rft.spage=147&rft.epage=154&rft.pages=147-154&rft.issn=0954-7894&rft.eissn=1365-2222&rft_id=info:doi/10.1111/j.1365-2222.1981.tb01578.x&rft_dat=%3Cproquest_cross%3E75669184%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=15316868&rft_id=info:pmid/7195321&rfr_iscdi=true |