Distribution and degradation of albumin in extensive skin disease
SUMMARY The distribution and degradation of albumin were determined in twelve patients with extensive skin disease and in ten control subjects by measuring the metabolic turnover and transcapillary escape of 131I‐labelled albumin. The ratio of intravascular to total mass of albumin was normal. Thus...
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| Veröffentlicht in: | British journal of dermatology (1951) 1981-04, Vol.104 (4), p.389-396 |
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| container_title | British journal of dermatology (1951) |
| container_volume | 104 |
| creator | WORM, A.-M. TAANING, E. ROSSING, N. PARVING, H.-H. CLEMMENSEN, O.J. |
| description | SUMMARY
The distribution and degradation of albumin were determined in twelve patients with extensive skin disease and in ten control subjects by measuring the metabolic turnover and transcapillary escape of 131I‐labelled albumin. The ratio of intravascular to total mass of albumin was normal. Thus the observed hypoalbuminaemia and the low intravascular mass reflect a reduced mass of total body albumin. The rate of synthesis was normal, but the transcapillary escape rate reflecting the micro‐vascular leakiness to macromolecules, and the fractional disappearance rate were significantly higher n i the patients than in the controls (P |
| doi_str_mv | 10.1111/j.1365-2133.1981.tb15308.x |
| format | Article |
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The distribution and degradation of albumin were determined in twelve patients with extensive skin disease and in ten control subjects by measuring the metabolic turnover and transcapillary escape of 131I‐labelled albumin. The ratio of intravascular to total mass of albumin was normal. Thus the observed hypoalbuminaemia and the low intravascular mass reflect a reduced mass of total body albumin. The rate of synthesis was normal, but the transcapillary escape rate reflecting the micro‐vascular leakiness to macromolecules, and the fractional disappearance rate were significantly higher n i the patients than in the controls (P<0·001). It is concluded that the hypoalbuminaemia in these patients is the result of an increased endogenous catabolism of albumin without signiflcant loss via urine, stools or skin. A positive correlation between the transcapillary escape rate and fractional catabolic rate of albumin supports the concept of a causal relationship between these parameters.</description><identifier>ISSN: 0007-0963</identifier><identifier>EISSN: 1365-2133</identifier><identifier>DOI: 10.1111/j.1365-2133.1981.tb15308.x</identifier><identifier>PMID: 6453604</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Albumins - biosynthesis ; Albumins - metabolism ; Capillaries - metabolism ; Dermatitis, Contact - metabolism ; Dermatitis, Exfoliative - metabolism ; Female ; Humans ; Male ; Middle Aged ; Psoriasis - metabolism ; Serum Albumin, Radio-Iodinated - metabolism ; Skin Diseases - metabolism</subject><ispartof>British journal of dermatology (1951), 1981-04, Vol.104 (4), p.389-396</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4079-da204ec058a19e6a29660831e75d492b3a7331bdd26cfa7c1b9ddb90d7fab65e3</citedby><cites>FETCH-LOGICAL-c4079-da204ec058a19e6a29660831e75d492b3a7331bdd26cfa7c1b9ddb90d7fab65e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2133.1981.tb15308.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2133.1981.tb15308.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6453604$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WORM, A.-M.</creatorcontrib><creatorcontrib>TAANING, E.</creatorcontrib><creatorcontrib>ROSSING, N.</creatorcontrib><creatorcontrib>PARVING, H.-H.</creatorcontrib><creatorcontrib>CLEMMENSEN, O.J.</creatorcontrib><title>Distribution and degradation of albumin in extensive skin disease</title><title>British journal of dermatology (1951)</title><addtitle>Br J Dermatol</addtitle><description>SUMMARY
The distribution and degradation of albumin were determined in twelve patients with extensive skin disease and in ten control subjects by measuring the metabolic turnover and transcapillary escape of 131I‐labelled albumin. The ratio of intravascular to total mass of albumin was normal. Thus the observed hypoalbuminaemia and the low intravascular mass reflect a reduced mass of total body albumin. The rate of synthesis was normal, but the transcapillary escape rate reflecting the micro‐vascular leakiness to macromolecules, and the fractional disappearance rate were significantly higher n i the patients than in the controls (P<0·001). It is concluded that the hypoalbuminaemia in these patients is the result of an increased endogenous catabolism of albumin without signiflcant loss via urine, stools or skin. A positive correlation between the transcapillary escape rate and fractional catabolic rate of albumin supports the concept of a causal relationship between these parameters.</description><subject>Adult</subject><subject>Aged</subject><subject>Albumins - biosynthesis</subject><subject>Albumins - metabolism</subject><subject>Capillaries - metabolism</subject><subject>Dermatitis, Contact - metabolism</subject><subject>Dermatitis, Exfoliative - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Psoriasis - metabolism</subject><subject>Serum Albumin, Radio-Iodinated - metabolism</subject><subject>Skin Diseases - metabolism</subject><issn>0007-0963</issn><issn>1365-2133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkFFr2zAQx0XZ6NKuH2Fg9rA3uyfLkqw9DNqkTTtCR6FrS1-EZJ2HUsdOLXt1v_2cJuR9h-A4_nc_wY-QrxQSOtbpMqFM8DiljCVU5TTpLOUM8mQ4IJN99IFMAEDGoAT7RI5CWAJQBhwOyaHIOBOQTcjZzIeu9bbvfFNHpnaRwz-tceZ9bsrIVLZf-ToaHw4d1sH_xSg8j6PzAU3Az-RjaaqAJ7t-TH5fXtxNr-LFr_n19GwRFxlIFTuTQoYF8NxQhcKkSgjIGUXJXaZSy4xkjFrnUlGURhbUKuesAidLYwVHdky-bbnrtnnpMXR65UOBVWVqbPqgJRci5ywdF79vF4u2CaHFUq9bvzLtm6agN_70Um8k6Y0kvfGnd_70MB5_2f3S2xW6_elO2Jj_2OavvsK3_yDr858zlqsREG8Bo3cc9gDTPmshmeT64Waub2Exz_jjk75n_wC2L49u</recordid><startdate>198104</startdate><enddate>198104</enddate><creator>WORM, A.-M.</creator><creator>TAANING, E.</creator><creator>ROSSING, N.</creator><creator>PARVING, H.-H.</creator><creator>CLEMMENSEN, O.J.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198104</creationdate><title>Distribution and degradation of albumin in extensive skin disease</title><author>WORM, A.-M. ; TAANING, E. ; ROSSING, N. ; PARVING, H.-H. ; CLEMMENSEN, O.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4079-da204ec058a19e6a29660831e75d492b3a7331bdd26cfa7c1b9ddb90d7fab65e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Albumins - biosynthesis</topic><topic>Albumins - metabolism</topic><topic>Capillaries - metabolism</topic><topic>Dermatitis, Contact - metabolism</topic><topic>Dermatitis, Exfoliative - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Psoriasis - metabolism</topic><topic>Serum Albumin, Radio-Iodinated - metabolism</topic><topic>Skin Diseases - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WORM, A.-M.</creatorcontrib><creatorcontrib>TAANING, E.</creatorcontrib><creatorcontrib>ROSSING, N.</creatorcontrib><creatorcontrib>PARVING, H.-H.</creatorcontrib><creatorcontrib>CLEMMENSEN, O.J.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of dermatology (1951)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WORM, A.-M.</au><au>TAANING, E.</au><au>ROSSING, N.</au><au>PARVING, H.-H.</au><au>CLEMMENSEN, O.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distribution and degradation of albumin in extensive skin disease</atitle><jtitle>British journal of dermatology (1951)</jtitle><addtitle>Br J Dermatol</addtitle><date>1981-04</date><risdate>1981</risdate><volume>104</volume><issue>4</issue><spage>389</spage><epage>396</epage><pages>389-396</pages><issn>0007-0963</issn><eissn>1365-2133</eissn><abstract>SUMMARY
The distribution and degradation of albumin were determined in twelve patients with extensive skin disease and in ten control subjects by measuring the metabolic turnover and transcapillary escape of 131I‐labelled albumin. The ratio of intravascular to total mass of albumin was normal. Thus the observed hypoalbuminaemia and the low intravascular mass reflect a reduced mass of total body albumin. The rate of synthesis was normal, but the transcapillary escape rate reflecting the micro‐vascular leakiness to macromolecules, and the fractional disappearance rate were significantly higher n i the patients than in the controls (P<0·001). It is concluded that the hypoalbuminaemia in these patients is the result of an increased endogenous catabolism of albumin without signiflcant loss via urine, stools or skin. A positive correlation between the transcapillary escape rate and fractional catabolic rate of albumin supports the concept of a causal relationship between these parameters.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>6453604</pmid><doi>10.1111/j.1365-2133.1981.tb15308.x</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-0963 |
| ispartof | British journal of dermatology (1951), 1981-04, Vol.104 (4), p.389-396 |
| issn | 0007-0963 1365-2133 |
| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Adult Aged Albumins - biosynthesis Albumins - metabolism Capillaries - metabolism Dermatitis, Contact - metabolism Dermatitis, Exfoliative - metabolism Female Humans Male Middle Aged Psoriasis - metabolism Serum Albumin, Radio-Iodinated - metabolism Skin Diseases - metabolism |
| title | Distribution and degradation of albumin in extensive skin disease |
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