Proliferative responses to purified and fractionated Bordetella pertussis antigens in mice immunized with whole-cell pertussis vaccine
The specificity of the cell-mediated immune response to Bordetella pertussis following immunization of C57B1 mice with a whole-cell pertussis vaccine was assessed in a proliferation assay. A proliferative response of lymph node lymphocytes to the filamentous haemagglutinin, the 69 kDa outer membrane...
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| Veröffentlicht in: | Vaccine 1993, Vol.11 (4), p.463-472 |
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| container_title | Vaccine |
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| creator | Petersen, Jesper W. Andersen, Peter Ibsen, Per H. Capiau, Carine Henrik Wachmann, C. Hasøv, Kaare Heron, Iver |
| description | The specificity of the cell-mediated immune response to
Bordetella pertussis following immunization of C57B1 mice with a whole-cell pertussis vaccine was assessed in a proliferation assay. A proliferative response of lymph node lymphocytes to the filamentous haemagglutinin, the 69 kDa outer membrane protein and the agglutinogens 2 and 3 was demonstrated. The proliferative cells were T cells of the CD4+ phenotype. In addition, several as yet uncharacterized antigens expressed by
B. pertussis were shown to induce a proliferative response, also mediated by T cells of the CD4+ phenotype. Although a range of different immunization schedules and preparations of pertussis toxin were used, no specific proliferative responses to pertussis toxin, which is regarded as a protective antigen of major importance from
B. pertussis, were found. |
| doi_str_mv | 10.1016/0264-410X(93)90289-A |
| format | Article |
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Bordetella pertussis following immunization of C57B1 mice with a whole-cell pertussis vaccine was assessed in a proliferation assay. A proliferative response of lymph node lymphocytes to the filamentous haemagglutinin, the 69 kDa outer membrane protein and the agglutinogens 2 and 3 was demonstrated. The proliferative cells were T cells of the CD4+ phenotype. In addition, several as yet uncharacterized antigens expressed by
B. pertussis were shown to induce a proliferative response, also mediated by T cells of the CD4+ phenotype. Although a range of different immunization schedules and preparations of pertussis toxin were used, no specific proliferative responses to pertussis toxin, which is regarded as a protective antigen of major importance from
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Bordetella pertussis following immunization of C57B1 mice with a whole-cell pertussis vaccine was assessed in a proliferation assay. A proliferative response of lymph node lymphocytes to the filamentous haemagglutinin, the 69 kDa outer membrane protein and the agglutinogens 2 and 3 was demonstrated. The proliferative cells were T cells of the CD4+ phenotype. In addition, several as yet uncharacterized antigens expressed by
B. pertussis were shown to induce a proliferative response, also mediated by T cells of the CD4+ phenotype. Although a range of different immunization schedules and preparations of pertussis toxin were used, no specific proliferative responses to pertussis toxin, which is regarded as a protective antigen of major importance from
B. pertussis, were found.</description><subject>Adhesins, Bacterial</subject><subject>Animals</subject><subject>Antibodies, Bacterial - biosynthesis</subject><subject>Antigens, Bacterial - isolation & purification</subject><subject>Bacterial Outer Membrane Proteins - immunology</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Bordetella pertussis</subject><subject>Bordetella pertussis - immunology</subject><subject>cell-mediated immune response</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. 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Psychology</topic><topic>Hemagglutinins - immunology</topic><topic>Immunity, Cellular</topic><topic>Immunization</topic><topic>In Vitro Techniques</topic><topic>Lymphocyte Activation</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Microbiology</topic><topic>Pertussis Toxin</topic><topic>Pertussis Vaccine - immunology</topic><topic>T-Lymphocyte Subsets - immunology</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</topic><topic>Virulence Factors, Bordetella - immunology</topic><topic>Whole-cell pertussis vaccine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Petersen, Jesper W.</creatorcontrib><creatorcontrib>Andersen, Peter</creatorcontrib><creatorcontrib>Ibsen, Per H.</creatorcontrib><creatorcontrib>Capiau, Carine</creatorcontrib><creatorcontrib>Henrik Wachmann, C.</creatorcontrib><creatorcontrib>Hasøv, Kaare</creatorcontrib><creatorcontrib>Heron, Iver</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Petersen, Jesper W.</au><au>Andersen, Peter</au><au>Ibsen, Per H.</au><au>Capiau, Carine</au><au>Henrik Wachmann, C.</au><au>Hasøv, Kaare</au><au>Heron, Iver</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Proliferative responses to purified and fractionated Bordetella pertussis antigens in mice immunized with whole-cell pertussis vaccine</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>1993</date><risdate>1993</risdate><volume>11</volume><issue>4</issue><spage>463</spage><epage>472</epage><pages>463-472</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>The specificity of the cell-mediated immune response to
Bordetella pertussis following immunization of C57B1 mice with a whole-cell pertussis vaccine was assessed in a proliferation assay. A proliferative response of lymph node lymphocytes to the filamentous haemagglutinin, the 69 kDa outer membrane protein and the agglutinogens 2 and 3 was demonstrated. The proliferative cells were T cells of the CD4+ phenotype. In addition, several as yet uncharacterized antigens expressed by
B. pertussis were shown to induce a proliferative response, also mediated by T cells of the CD4+ phenotype. Although a range of different immunization schedules and preparations of pertussis toxin were used, no specific proliferative responses to pertussis toxin, which is regarded as a protective antigen of major importance from
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| subjects | Adhesins, Bacterial Animals Antibodies, Bacterial - biosynthesis Antigens, Bacterial - isolation & purification Bacterial Outer Membrane Proteins - immunology Bacteriology Biological and medical sciences Bordetella pertussis Bordetella pertussis - immunology cell-mediated immune response Female Fundamental and applied biological sciences. Psychology Hemagglutinins - immunology Immunity, Cellular Immunization In Vitro Techniques Lymphocyte Activation Mice Mice, Inbred C57BL Microbiology Pertussis Toxin Pertussis Vaccine - immunology T-Lymphocyte Subsets - immunology Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Virulence Factors, Bordetella - immunology Whole-cell pertussis vaccine |
| title | Proliferative responses to purified and fractionated Bordetella pertussis antigens in mice immunized with whole-cell pertussis vaccine |
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