Characterization of adenylate cyclase toxin from a mutant of Bordetella pertussis defective in the activator gene, cyaC

Bordetella pertussis adenylate cyclase (AC) toxin has the abilities to 1) enter target cells where it catalyzes cyclic AMP production and 2) lyse sheep erythrocytes, and these abilities require post-translational modification by the product of an accessory gene cyaC (Barry, E. M., Weiss, A. A., Ehrm...

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Veröffentlicht in:	The Journal of biological chemistry 1993-04, Vol.268 (11), p.7842-7848
Hauptverfasser:	HEWLETT, E. L, GRAY, M. C, EHRMANN, I. E, MALONEY, N. J, OTERO, A. S, GRAY, L, ALLIETTA, M, SZABO, G, WEISS, A. A, BARRY, E. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylate Cyclase Toxin Adenylyl Cyclases - genetics Adenylyl Cyclases - isolation & purification Adenylyl Cyclases - metabolism Animals Bacteriology Biological and medical sciences Bordetella pertussis - enzymology Bordetella pertussis - genetics Calcium - metabolism Calcium Channels - drug effects Calcium Channels - physiology Cell Line Cells, Cultured Cyclic AMP - metabolism Electrophysiology - methods Fundamental and applied biological sciences. Psychology Genes, Bacterial Genes, Regulator Heart - drug effects Heart - physiology Hemolysis Humans In Vitro Techniques Microbiology Models, Biological Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains Protein Conformation Protein Processing, Post-Translational Rana catesbeiana Recombinant Proteins - isolation & purification Recombinant Proteins - metabolism Recombinant Proteins - pharmacology Spectrometry, Fluorescence T-Lymphocytes, Helper-Inducer Virulence Factors, Bordetella - genetics Virulence Factors, Bordetella - isolation & purification Virulence Factors, Bordetella - pharmacology
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