Long-term effects of weight reduction on serum lipids and plasma insulin in obese children
The long-term metabolic effects of weight reduction on serum lipids and plasma insulin were evaluated in 32 obese children with a mean (±SD) relative weight of 160.9 ± 20.1 % before and after active treatment for 1 y and after observation for another 4 y. The obese subjects had higher serum triglyce...
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| Veröffentlicht in: | The American journal of clinical nutrition 1993-04, Vol.57 (4), p.490-493 |
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| creator | Knip, M Nuutinen, O |
| description | The long-term metabolic effects of weight reduction on serum lipids and plasma insulin were evaluated in 32 obese children with a mean (±SD) relative weight of 160.9 ± 20.1 % before and after active treatment for 1 y and after observation for another 4 y. The obese subjects had higher serum triglyceride and plasma insulin concentrations initially but lower high-density-lipoprotein (HDL)-cholesterol concentrations and a lower ratio of HDL cholesterol to total cholesterol (TC) than 29 normal-weight children. There was a decrease of 15.8% in relative weight over the first year with a parallel decrease in serum triglyceride and plasma insulin, whereas HDL cholesterol and the ratio of HDL cholesterol to TC increased (P < 0.001). These changes remained stable over the second year. At 5 y the obese subjects still had a reduced weight (12.8% lower than initially) and higher HDL cholesterol. These results indicate that weight reduction in obese children is associated with a change in serum lipids toward normal and reduced peripheral hyperinsulinemia. |
| doi_str_mv | 10.1093/ajcn/57.4.490 |
| format | Article |
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The obese subjects had higher serum triglyceride and plasma insulin concentrations initially but lower high-density-lipoprotein (HDL)-cholesterol concentrations and a lower ratio of HDL cholesterol to total cholesterol (TC) than 29 normal-weight children. There was a decrease of 15.8% in relative weight over the first year with a parallel decrease in serum triglyceride and plasma insulin, whereas HDL cholesterol and the ratio of HDL cholesterol to TC increased (P < 0.001). These changes remained stable over the second year. At 5 y the obese subjects still had a reduced weight (12.8% lower than initially) and higher HDL cholesterol. These results indicate that weight reduction in obese children is associated with a change in serum lipids toward normal and reduced peripheral hyperinsulinemia.</description><identifier>ISSN: 0002-9165</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.1093/ajcn/57.4.490</identifier><identifier>PMID: 8460603</identifier><identifier>CODEN: AJCNAC</identifier><language>eng</language><publisher>Bethesda, MD: Elsevier Inc</publisher><subject>Adolescent ; Anthropometry ; Biological and medical sciences ; blood ; Child ; Childhood obesity ; children ; Children & youth ; cholesterol ; colesterol ; dieta terapeutica ; enfant ; experimentation ; experimentos ; experiments ; Humans ; Insulin ; Insulin - blood ; insulina ; insuline ; jeunesse ; juventud ; lipaemia ; lipemia ; lipemie ; lipids ; Lipids - blood ; lipoproteinas ; lipoproteine ; lipoproteins ; Long-Term Care ; Medical research ; Medical sciences ; Metabolic diseases ; Metabolism ; ninos ; Obesity ; Obesity - blood ; Obesity - therapy ; overweight ; reduccion del peso ; regime alimentaire therapeutique ; regime pour reduction de poids ; sang ; sangre ; sobrepeso ; surpoids ; therapeutic diets ; trigliceridos ; triglyceride ; triglycerides ; Weight control ; Weight Loss - physiology ; weight reduction ; youth</subject><ispartof>The American journal of clinical nutrition, 1993-04, Vol.57 (4), p.490-493</ispartof><rights>1993 American Society for Nutrition.</rights><rights>1993 INIST-CNRS</rights><rights>Copyright American Society for Clinical Nutrition, Inc. Apr 1993</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c520t-e6770ca71a69b298dd360eaa0cb0edee41de1306969a2471812b3b2a30c55ba33</citedby><cites>FETCH-LOGICAL-c520t-e6770ca71a69b298dd360eaa0cb0edee41de1306969a2471812b3b2a30c55ba33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4769821$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8460603$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Knip, M</creatorcontrib><creatorcontrib>Nuutinen, O</creatorcontrib><creatorcontrib>University of Oulu, Oulu, Finland</creatorcontrib><title>Long-term effects of weight reduction on serum lipids and plasma insulin in obese children</title><title>The American journal of clinical nutrition</title><addtitle>Am J Clin Nutr</addtitle><description>The long-term metabolic effects of weight reduction on serum lipids and plasma insulin were evaluated in 32 obese children with a mean (±SD) relative weight of 160.9 ± 20.1 % before and after active treatment for 1 y and after observation for another 4 y. The obese subjects had higher serum triglyceride and plasma insulin concentrations initially but lower high-density-lipoprotein (HDL)-cholesterol concentrations and a lower ratio of HDL cholesterol to total cholesterol (TC) than 29 normal-weight children. There was a decrease of 15.8% in relative weight over the first year with a parallel decrease in serum triglyceride and plasma insulin, whereas HDL cholesterol and the ratio of HDL cholesterol to TC increased (P < 0.001). These changes remained stable over the second year. At 5 y the obese subjects still had a reduced weight (12.8% lower than initially) and higher HDL cholesterol. These results indicate that weight reduction in obese children is associated with a change in serum lipids toward normal and reduced peripheral hyperinsulinemia.</description><subject>Adolescent</subject><subject>Anthropometry</subject><subject>Biological and medical sciences</subject><subject>blood</subject><subject>Child</subject><subject>Childhood obesity</subject><subject>children</subject><subject>Children & youth</subject><subject>cholesterol</subject><subject>colesterol</subject><subject>dieta terapeutica</subject><subject>enfant</subject><subject>experimentation</subject><subject>experimentos</subject><subject>experiments</subject><subject>Humans</subject><subject>Insulin</subject><subject>Insulin - blood</subject><subject>insulina</subject><subject>insuline</subject><subject>jeunesse</subject><subject>juventud</subject><subject>lipaemia</subject><subject>lipemia</subject><subject>lipemie</subject><subject>lipids</subject><subject>Lipids - blood</subject><subject>lipoproteinas</subject><subject>lipoproteine</subject><subject>lipoproteins</subject><subject>Long-Term Care</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Metabolism</subject><subject>ninos</subject><subject>Obesity</subject><subject>Obesity - blood</subject><subject>Obesity - therapy</subject><subject>overweight</subject><subject>reduccion del peso</subject><subject>regime alimentaire therapeutique</subject><subject>regime pour reduction de poids</subject><subject>sang</subject><subject>sangre</subject><subject>sobrepeso</subject><subject>surpoids</subject><subject>therapeutic diets</subject><subject>trigliceridos</subject><subject>triglyceride</subject><subject>triglycerides</subject><subject>Weight control</subject><subject>Weight Loss - physiology</subject><subject>weight reduction</subject><subject>youth</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10U2LFDEQBuBGlHVcPXpUgoi3nq10vjpHWfyCAQ-6Fy8hnVTPZuhOxqRb8d-bYYY9CEKgDvVQKd5qmpcUthQ0u7EHF2-E2vIt1_Co2VDN-pZ1oB43GwDoWk2leNo8K-UAQDvey6vmqucSJLBN82OX4r5dMM8ExxHdUkgayW8M-_uFZPSrW0KKpL6CeZ3JFI7BF2KjJ8fJltmSEMs6hVgrSQMWJO4-TD5jfN48Ge1U8MWlXjd3Hz98v_3c7r5--nL7ftc60cHSolQKnFXUSj10uveeSUBrwQ2AHpFTj5SB1FLbjiva025gQ2cZOCEGy9h18-4895jTzxXLYuZQHE6TjZjWYpSQsgfBK3zzDzykNce6m-kY1ZyJXlTUnpHLqZSMoznmMNv8x1Awp8DNKXAjlOGmBl79q8vQdZjRP-hLwrX_9tK3xdlpzDa6UB4YV1L3Ha3s9ZmNNhm7z5XcfaNacwAGuj_9o84Aa5S_AmZTXMDo0Idcz2Z8Cv_Z8C8sDKR_</recordid><startdate>19930401</startdate><enddate>19930401</enddate><creator>Knip, M</creator><creator>Nuutinen, O</creator><general>Elsevier Inc</general><general>American Society for Clinical Nutrition</general><general>American Society for Clinical Nutrition, Inc</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T7</scope><scope>7TS</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19930401</creationdate><title>Long-term effects of weight reduction on serum lipids and plasma insulin in obese children</title><author>Knip, M ; Nuutinen, O</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c520t-e6770ca71a69b298dd360eaa0cb0edee41de1306969a2471812b3b2a30c55ba33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adolescent</topic><topic>Anthropometry</topic><topic>Biological and medical sciences</topic><topic>blood</topic><topic>Child</topic><topic>Childhood obesity</topic><topic>children</topic><topic>Children & youth</topic><topic>cholesterol</topic><topic>colesterol</topic><topic>dieta terapeutica</topic><topic>enfant</topic><topic>experimentation</topic><topic>experimentos</topic><topic>experiments</topic><topic>Humans</topic><topic>Insulin</topic><topic>Insulin - blood</topic><topic>insulina</topic><topic>insuline</topic><topic>jeunesse</topic><topic>juventud</topic><topic>lipaemia</topic><topic>lipemia</topic><topic>lipemie</topic><topic>lipids</topic><topic>Lipids - blood</topic><topic>lipoproteinas</topic><topic>lipoproteine</topic><topic>lipoproteins</topic><topic>Long-Term Care</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Metabolism</topic><topic>ninos</topic><topic>Obesity</topic><topic>Obesity - blood</topic><topic>Obesity - therapy</topic><topic>overweight</topic><topic>reduccion del peso</topic><topic>regime alimentaire therapeutique</topic><topic>regime pour reduction de poids</topic><topic>sang</topic><topic>sangre</topic><topic>sobrepeso</topic><topic>surpoids</topic><topic>therapeutic diets</topic><topic>trigliceridos</topic><topic>triglyceride</topic><topic>triglycerides</topic><topic>Weight control</topic><topic>Weight Loss - physiology</topic><topic>weight reduction</topic><topic>youth</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Knip, M</creatorcontrib><creatorcontrib>Nuutinen, O</creatorcontrib><creatorcontrib>University of Oulu, Oulu, Finland</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Knip, M</au><au>Nuutinen, O</au><aucorp>University of Oulu, Oulu, Finland</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-term effects of weight reduction on serum lipids and plasma insulin in obese children</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>1993-04-01</date><risdate>1993</risdate><volume>57</volume><issue>4</issue><spage>490</spage><epage>493</epage><pages>490-493</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><coden>AJCNAC</coden><abstract>The long-term metabolic effects of weight reduction on serum lipids and plasma insulin were evaluated in 32 obese children with a mean (±SD) relative weight of 160.9 ± 20.1 % before and after active treatment for 1 y and after observation for another 4 y. The obese subjects had higher serum triglyceride and plasma insulin concentrations initially but lower high-density-lipoprotein (HDL)-cholesterol concentrations and a lower ratio of HDL cholesterol to total cholesterol (TC) than 29 normal-weight children. There was a decrease of 15.8% in relative weight over the first year with a parallel decrease in serum triglyceride and plasma insulin, whereas HDL cholesterol and the ratio of HDL cholesterol to TC increased (P < 0.001). These changes remained stable over the second year. At 5 y the obese subjects still had a reduced weight (12.8% lower than initially) and higher HDL cholesterol. These results indicate that weight reduction in obese children is associated with a change in serum lipids toward normal and reduced peripheral hyperinsulinemia.</abstract><cop>Bethesda, MD</cop><pub>Elsevier Inc</pub><pmid>8460603</pmid><doi>10.1093/ajcn/57.4.490</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Anthropometry Biological and medical sciences blood Child Childhood obesity children Children & youth cholesterol colesterol dieta terapeutica enfant experimentation experimentos experiments Humans Insulin Insulin - blood insulina insuline jeunesse juventud lipaemia lipemia lipemie lipids Lipids - blood lipoproteinas lipoproteine lipoproteins Long-Term Care Medical research Medical sciences Metabolic diseases Metabolism ninos Obesity Obesity - blood Obesity - therapy overweight reduccion del peso regime alimentaire therapeutique regime pour reduction de poids sang sangre sobrepeso surpoids therapeutic diets trigliceridos triglyceride triglycerides Weight control Weight Loss - physiology weight reduction youth |
| title | Long-term effects of weight reduction on serum lipids and plasma insulin in obese children |
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