Bicuculline-insensitive gaba receptors on peripheral autonomic nerve terminals

The action of γ-aminobutyric acid (GABA) and related compounds on rat isolated atria and mouse and guinea-pig isolated vas deferens has been studied. GABA depressed the evoked but not basal release of [ 3H]noradrenaline from atria (IC 50 4 μM) and reduced the twitch responses of the vas deferens (IC...

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Veröffentlicht in:	European journal of pharmacology 1981-04, Vol.71 (1), p.53-70
Hauptverfasser:	Bowery, Norman G., Doble, Adam, Hill, David R., Hudson, Alan L., Shaw, John S., Turnbull, Michael J., Warrington, Ruth
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autonomic nerve terminals Autonomic Nervous System - metabolism Baclofen Baclofen - pharmacology Bicuculline insensitivity Dose-Response Relationship, Drug GABA Antagonists GABA receptor gamma-Aminobutyric Acid - pharmacology Heart Atria - metabolism Male Norepinephrine - metabolism Rats Receptors, Cell Surface - metabolism Receptors, GABA-A Transmitter release Vas Deferens - metabolism
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