Novel Insights into the Global Proteome Responses of Insulin-Producing INS-1E Cells To Different Degrees of Endoplasmic Reticulum Stress

Exposure of insulin-secreting β-cells to inflammatory cytokines or high concentrations of free fatty acids, factors involved in the pathogenesis of type 1 and type 2 diabetes, leads to endoplasmic reticulum (ER) stress, β-cell dysfunction, and eventually apoptotic β-cell death. The aim of this study...

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Veröffentlicht in:	Journal of proteome research 2010-10, Vol.9 (10), p.5142-5152
Hauptverfasser:	D’Hertog, Wannes, Maris, Michael, Ferreira, Gabriela B, Verdrengh, Eefje, Lage, Kasper, Hansen, Daniel A, Cardozo, Alessandra K, Workman, Christopher T, Moreau, Yves, Eizirik, Decio L, Waelkens, Etienne, Overbergh, Lutgart, Mathieu, Chantal
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Blotting, Western Cell Line, Tumor Electrophoresis, Gel, Two-Dimensional Endoplasmic Reticulum - drug effects Endoplasmic Reticulum - metabolism Enzyme Inhibitors - pharmacology Gene Expression - drug effects Indoles - pharmacology Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism Insulinoma - metabolism Insulinoma - pathology Protein Binding - drug effects Proteome - analysis Proteome - genetics Proteomics - methods Rats Reverse Transcriptase Polymerase Chain Reaction Signal Transduction - drug effects Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
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