Δ9‐Tetrahydrocannabivarin suppresses in vitro epileptiform and in vivo seizure activity in adult rats

Summary Purpose: We assessed the anticonvulsant potential of the phytocannabinoid Δ9‐tetrahydrocannabivarin (Δ9‐THCV) by investigating its effects in an in vitro piriform cortex (PC) brain slice model of epileptiform activity, on cannabinoid CB1 receptor radioligand‐binding assays and in a generali...

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Veröffentlicht in:	Epilepsia (Copenhagen) 2010-08, Vol.51 (8), p.1522-1532
Hauptverfasser:	Hill, Andrew J., Weston, Samantha E., Jones, Nicholas A., Smith, Imogen, Bevan, Sarah A., Williamson, Elizabeth M., Stephens, Gary J., Williams, Claire M., Whalley, Benjamin J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticonvulsant Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Cannabinoid Cerebral Cortex - drug effects Cerebral Cortex - physiology Competitive Bidding - methods Disease Models, Animal Dronabinol - analogs & derivatives Dronabinol - pharmacology Dronabinol - therapeutic use Drug Interactions Epilepsy Epilepsy - chemically induced Epilepsy - drug therapy Epilepsy - physiopathology Evoked Potentials - drug effects Female Guanosine 5'-O-(3-Thiotriphosphate) - metabolism Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy In Vitro Techniques Male Medical sciences Nervous system (semeiology, syndromes) Neurology Neuropharmacology Pentylenetetrazole Pharmacology. Drug treatments Phosphorus Isotopes - metabolism Piperidines - pharmacokinetics Piriform cortex Pyrazoles - pharmacokinetics Rats Receptor, Cannabinoid, CB1 - agonists Receptor, Cannabinoid, CB1 - antagonists & inhibitors
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