Tongxinluo reduces myocardial no-reflow and ischemia-reperfusion injury by stimulating the phosphorylation of eNOS via the PKA pathway

The objective of the present study was to investigate whether pretreatment with single low loading dose of tongxinluo (TXL), a traditional Chinese medicine, 1 h before myocardial ischemia could attenuate no-reflow and ischemia-reperfusion injury by regulating endothelial nitric oxide synthase (eNOS)...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2010-10, Vol.299 (4), p.H1255-H1261
Hauptverfasser:	Li, Xiang-Dong, Yang, Yue-Jin, Geng, Yong-Jian, Jin, Chen, Hu, Feng-Huan, Zhao, Jing-Lin, Zhang, Hai-Tao, Cheng, Yu-Tong, Qian, Hai-Yan, Wang, Lin-Lin, Zhang, Bao-Jie, Wu, Yi-Ling
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chinese medicine Creatine Kinase - blood Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors Cyclic AMP-Dependent Protein Kinases - metabolism Dose-Response Relationship, Drug Drugs, Chinese Herbal - pharmacology Drugs, Chinese Herbal - therapeutic use Gene expression Heart attacks Ischemia Isoquinolines - pharmacology Models, Animal Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - prevention & control Nitric oxide Nitric Oxide Synthase Type III - metabolism Phosphorylation Physiology Protein Kinase Inhibitors - pharmacology Signal Transduction - drug effects Signal Transduction - physiology Sulfonamides - pharmacology Swine Swine, Miniature
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