Obsessive-compulsive disorder and obsessive-compulsive symptoms in Japanese inpatients with chronic schizophrenia – A possible schizophrenic subtype
Abstract To investigate the prevalence of obsessive-compulsive disorder (OCD) and obsessive-compulsive symptoms (OCS) and their association with demographic and clinical factors, 92 inpatients with chronic schizophrenia participated in this study. Demographic factors, severity of psychiatric symptom...
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| Veröffentlicht in: | Psychiatry research 2010-10, Vol.179 (3), p.241-246 |
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| creator | Owashi, Toshimi Ota, Arimitsu Otsubo, Tempei Susa, Yuko Kamijima, Kunitoshi |
| description | Abstract To investigate the prevalence of obsessive-compulsive disorder (OCD) and obsessive-compulsive symptoms (OCS) and their association with demographic and clinical factors, 92 inpatients with chronic schizophrenia participated in this study. Demographic factors, severity of psychiatric symptoms as determined by Brief Psychiatric Rating Scale and OCS by Yale–Brown Obsessive Compulsive Scale, general functioning, extrapyramidal symptoms, and dose of antipsychotics were compared between patients with and without OCD or OCS. The Mini-International Neuropsychiatric Interview was employed for diagnosis of OCD and OCS. OCD and OCS were observed in 14.1% and 51.1% of inpatients with schizophrenia, respectively. Schizophrenic patients with OCS exhibited significantly earlier onset of schizophrenia, lower socioeconomic status, and more severe psychiatric symptoms than those without OCS. Earlier hospitalization of schizophrenia, family history of psychosis, and more severe schizophrenic symptoms were associated with comorbidity of OCS, as determined by logistic regression analysis, and younger age was associated with more severe OCS. However, negative symptoms were associated with comorbidity of OCD in chronic schizophrenia. Our findings suggest there is a subtype of schizophrenia with OCS, which is related to earlier onset and more severe psychotic symptoms. |
| doi_str_mv | 10.1016/j.psychres.2009.08.003 |
| format | Article |
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Demographic factors, severity of psychiatric symptoms as determined by Brief Psychiatric Rating Scale and OCS by Yale–Brown Obsessive Compulsive Scale, general functioning, extrapyramidal symptoms, and dose of antipsychotics were compared between patients with and without OCD or OCS. The Mini-International Neuropsychiatric Interview was employed for diagnosis of OCD and OCS. OCD and OCS were observed in 14.1% and 51.1% of inpatients with schizophrenia, respectively. Schizophrenic patients with OCS exhibited significantly earlier onset of schizophrenia, lower socioeconomic status, and more severe psychiatric symptoms than those without OCS. Earlier hospitalization of schizophrenia, family history of psychosis, and more severe schizophrenic symptoms were associated with comorbidity of OCS, as determined by logistic regression analysis, and younger age was associated with more severe OCS. However, negative symptoms were associated with comorbidity of OCD in chronic schizophrenia. Our findings suggest there is a subtype of schizophrenia with OCS, which is related to earlier onset and more severe psychotic symptoms.</description><identifier>ISSN: 0165-1781</identifier><identifier>EISSN: 1872-7123</identifier><identifier>DOI: 10.1016/j.psychres.2009.08.003</identifier><identifier>PMID: 20483470</identifier><identifier>CODEN: PSRSDR</identifier><language>eng</language><publisher>Kidlington: Elsevier Ireland Ltd</publisher><subject>Adult ; Adult and adolescent clinical studies ; Age at onset ; Age of Onset ; Aged ; Antipsychotic Agents - therapeutic use ; Anxiety disorders. Neuroses ; Biological and medical sciences ; Comorbidity ; Female ; Humans ; Inpatients ; Interview, Psychological ; Japan - epidemiology ; Logistic Models ; Male ; Medical sciences ; Middle Aged ; Negative symptom ; Obsessive-Compulsive Disorder - diagnosis ; Obsessive-Compulsive Disorder - epidemiology ; Obsessive-compulsive disorders ; Positive symptom ; Prevalence ; Psychiatric Status Rating Scales ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Schizophrenia ; Schizophrenia - diagnosis ; Schizophrenia - drug therapy ; Schizophrenia - epidemiology ; Severity of Illness Index ; Socioeconomic Factors ; Yale–Brown Obsessive Compulsive Scale</subject><ispartof>Psychiatry research, 2010-10, Vol.179 (3), p.241-246</ispartof><rights>Elsevier Ltd</rights><rights>2009 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2009 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-fc1e7936de983bf18e5410c2da488556216f0d915908624bf80a254c52cfa0b83</citedby><cites>FETCH-LOGICAL-c452t-fc1e7936de983bf18e5410c2da488556216f0d915908624bf80a254c52cfa0b83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.psychres.2009.08.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23328525$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20483470$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Owashi, Toshimi</creatorcontrib><creatorcontrib>Ota, Arimitsu</creatorcontrib><creatorcontrib>Otsubo, Tempei</creatorcontrib><creatorcontrib>Susa, Yuko</creatorcontrib><creatorcontrib>Kamijima, Kunitoshi</creatorcontrib><title>Obsessive-compulsive disorder and obsessive-compulsive symptoms in Japanese inpatients with chronic schizophrenia – A possible schizophrenic subtype</title><title>Psychiatry research</title><addtitle>Psychiatry Res</addtitle><description>Abstract To investigate the prevalence of obsessive-compulsive disorder (OCD) and obsessive-compulsive symptoms (OCS) and their association with demographic and clinical factors, 92 inpatients with chronic schizophrenia participated in this study. Demographic factors, severity of psychiatric symptoms as determined by Brief Psychiatric Rating Scale and OCS by Yale–Brown Obsessive Compulsive Scale, general functioning, extrapyramidal symptoms, and dose of antipsychotics were compared between patients with and without OCD or OCS. The Mini-International Neuropsychiatric Interview was employed for diagnosis of OCD and OCS. OCD and OCS were observed in 14.1% and 51.1% of inpatients with schizophrenia, respectively. Schizophrenic patients with OCS exhibited significantly earlier onset of schizophrenia, lower socioeconomic status, and more severe psychiatric symptoms than those without OCS. Earlier hospitalization of schizophrenia, family history of psychosis, and more severe schizophrenic symptoms were associated with comorbidity of OCS, as determined by logistic regression analysis, and younger age was associated with more severe OCS. However, negative symptoms were associated with comorbidity of OCD in chronic schizophrenia. Our findings suggest there is a subtype of schizophrenia with OCS, which is related to earlier onset and more severe psychotic symptoms.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Age at onset</subject><subject>Age of Onset</subject><subject>Aged</subject><subject>Antipsychotic Agents - therapeutic use</subject><subject>Anxiety disorders. Neuroses</subject><subject>Biological and medical sciences</subject><subject>Comorbidity</subject><subject>Female</subject><subject>Humans</subject><subject>Inpatients</subject><subject>Interview, Psychological</subject><subject>Japan - epidemiology</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Negative symptom</subject><subject>Obsessive-Compulsive Disorder - diagnosis</subject><subject>Obsessive-Compulsive Disorder - epidemiology</subject><subject>Obsessive-compulsive disorders</subject><subject>Positive symptom</subject><subject>Prevalence</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Schizophrenia</subject><subject>Schizophrenia - diagnosis</subject><subject>Schizophrenia - drug therapy</subject><subject>Schizophrenia - epidemiology</subject><subject>Severity of Illness Index</subject><subject>Socioeconomic Factors</subject><subject>Yale–Brown Obsessive Compulsive Scale</subject><issn>0165-1781</issn><issn>1872-7123</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks9u1DAQxiMEoqXwCpUviFOWsR0nzgVRVfxVpR6As-U4E62XJA6epGg58Q5IPCBPgqPdgkBInDySfzP-_H2TZeccNhx4-XS3mWjvthFpIwDqDegNgLyTnXJdibziQt7NThOocl5pfpI9INoBgOB1fT87EVBoWVRwmn2_bgiJ_A3mLgzT0q8laz2F2GJkdmxZ-BdB-2Gaw0DMj-ytneyIhKme7OxxnIl99vOWJX1h9I6R2_ovYUpqR2_Zj6_f2AWbQprZ9PjHZUKXZt5P-DC719me8NHxPMs-vHzx_vJ1fnX96s3lxVXuCiXmvHMcq1qWLdZaNh3XqAoOTrS20FqpUvCyg7bmqgZdiqLpNFihCqeE6yw0Wp5lTw5zpxg-LUizGTw57Pv0obCQqVRZlrJUKpHlgXQxKY_YmSn6wca94WDWSMzO3EZi1kgMaJMiSY3nxyeWZsD2V9ttBgl4fAQsOdt30Y7O029OSqGVWBU8P3CYDLnxGA25ZLbD1kd0s2mD_7-WZ3-NcL1Pttv-I-6RdmGJY7LbcEPCgHm3LtC6P1Cn1amlkj8BQ2fH3Q</recordid><startdate>20101030</startdate><enddate>20101030</enddate><creator>Owashi, Toshimi</creator><creator>Ota, Arimitsu</creator><creator>Otsubo, Tempei</creator><creator>Susa, Yuko</creator><creator>Kamijima, Kunitoshi</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20101030</creationdate><title>Obsessive-compulsive disorder and obsessive-compulsive symptoms in Japanese inpatients with chronic schizophrenia – A possible schizophrenic subtype</title><author>Owashi, Toshimi ; Ota, Arimitsu ; Otsubo, Tempei ; Susa, Yuko ; Kamijima, Kunitoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-fc1e7936de983bf18e5410c2da488556216f0d915908624bf80a254c52cfa0b83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Age at onset</topic><topic>Age of Onset</topic><topic>Aged</topic><topic>Antipsychotic Agents - therapeutic use</topic><topic>Anxiety disorders. Neuroses</topic><topic>Biological and medical sciences</topic><topic>Comorbidity</topic><topic>Female</topic><topic>Humans</topic><topic>Inpatients</topic><topic>Interview, Psychological</topic><topic>Japan - epidemiology</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Negative symptom</topic><topic>Obsessive-Compulsive Disorder - diagnosis</topic><topic>Obsessive-Compulsive Disorder - epidemiology</topic><topic>Obsessive-compulsive disorders</topic><topic>Positive symptom</topic><topic>Prevalence</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Schizophrenia</topic><topic>Schizophrenia - diagnosis</topic><topic>Schizophrenia - drug therapy</topic><topic>Schizophrenia - epidemiology</topic><topic>Severity of Illness Index</topic><topic>Socioeconomic Factors</topic><topic>Yale–Brown Obsessive Compulsive Scale</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Owashi, Toshimi</creatorcontrib><creatorcontrib>Ota, Arimitsu</creatorcontrib><creatorcontrib>Otsubo, Tempei</creatorcontrib><creatorcontrib>Susa, Yuko</creatorcontrib><creatorcontrib>Kamijima, Kunitoshi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Psychiatry research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Owashi, Toshimi</au><au>Ota, Arimitsu</au><au>Otsubo, Tempei</au><au>Susa, Yuko</au><au>Kamijima, Kunitoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Obsessive-compulsive disorder and obsessive-compulsive symptoms in Japanese inpatients with chronic schizophrenia – A possible schizophrenic subtype</atitle><jtitle>Psychiatry research</jtitle><addtitle>Psychiatry Res</addtitle><date>2010-10-30</date><risdate>2010</risdate><volume>179</volume><issue>3</issue><spage>241</spage><epage>246</epage><pages>241-246</pages><issn>0165-1781</issn><eissn>1872-7123</eissn><coden>PSRSDR</coden><abstract>Abstract To investigate the prevalence of obsessive-compulsive disorder (OCD) and obsessive-compulsive symptoms (OCS) and their association with demographic and clinical factors, 92 inpatients with chronic schizophrenia participated in this study. Demographic factors, severity of psychiatric symptoms as determined by Brief Psychiatric Rating Scale and OCS by Yale–Brown Obsessive Compulsive Scale, general functioning, extrapyramidal symptoms, and dose of antipsychotics were compared between patients with and without OCD or OCS. The Mini-International Neuropsychiatric Interview was employed for diagnosis of OCD and OCS. OCD and OCS were observed in 14.1% and 51.1% of inpatients with schizophrenia, respectively. Schizophrenic patients with OCS exhibited significantly earlier onset of schizophrenia, lower socioeconomic status, and more severe psychiatric symptoms than those without OCS. Earlier hospitalization of schizophrenia, family history of psychosis, and more severe schizophrenic symptoms were associated with comorbidity of OCS, as determined by logistic regression analysis, and younger age was associated with more severe OCS. However, negative symptoms were associated with comorbidity of OCD in chronic schizophrenia. Our findings suggest there is a subtype of schizophrenia with OCS, which is related to earlier onset and more severe psychotic symptoms.</abstract><cop>Kidlington</cop><pub>Elsevier Ireland Ltd</pub><pmid>20483470</pmid><doi>10.1016/j.psychres.2009.08.003</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Adult and adolescent clinical studies Age at onset Age of Onset Aged Antipsychotic Agents - therapeutic use Anxiety disorders. Neuroses Biological and medical sciences Comorbidity Female Humans Inpatients Interview, Psychological Japan - epidemiology Logistic Models Male Medical sciences Middle Aged Negative symptom Obsessive-Compulsive Disorder - diagnosis Obsessive-Compulsive Disorder - epidemiology Obsessive-compulsive disorders Positive symptom Prevalence Psychiatric Status Rating Scales Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Schizophrenia Schizophrenia - diagnosis Schizophrenia - drug therapy Schizophrenia - epidemiology Severity of Illness Index Socioeconomic Factors Yale–Brown Obsessive Compulsive Scale |
| title | Obsessive-compulsive disorder and obsessive-compulsive symptoms in Japanese inpatients with chronic schizophrenia – A possible schizophrenic subtype |
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